Comparative evaluation of antepartum and postpartum platelet function in smokers and nonsmokers

Leuschen, M. Patricia; Davis, Richard A.; Boyd, David; Goodlin, Robert C.

doi:10.1016/0002-9378(86)90159-6

Cited by 12 publications

(3 citation statements)

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“…Increased platelet aggregation has been reported with a variety of aggregating agents (Andrews et al 1985; Lewis et al 1980; Hoche et al 1983). Leuschen et al (1986), using an impedance method and concentrations of aggregating agents at least 10 times greater than those used in the present study, found similar increases in whole blood platelet aggregation at 25 and 31 weeks gestation when compared with 4–6 weeks postpartum . In a longitudinal study of eight patients, Louden et al (1990) found an increased whole blood platelet response to AA and adrenaline in the third trimester of normal pregnancy.…”

Section: Discussionsupporting

confidence: 72%

“…Pro‐aggregatory thromboxane A2 (TXA2) is increased in normal pregnancy (Ylikorkala et al 1980) and the site of this increased biosynthesis is mainly in platelets (Fitzgerald et al 1987). Increased platelet aggregation has been reported in normal pregnancy using platelet rich plasma (Leuschen et al 1986; Andrews et al 1985). Louden et al (1990) studied eight women longitudinally and found that platelet aggregation increased in response to some aggregating agents, although serum TXA2 was unchanged.…”

mentioning

confidence: 99%

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Increased whole blood platelet aggregation in normal pregnancy can be prevented in vitro by aspirin and dazmegrel (UK38485)

Norris

Sheppard

Bonnar

1992

BJOG

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Objective To determine the effect of normal pregnancy and the early puerperium on whole blood platelet aggregation and to assess the role of thromboxane A2 (TXA2) in platelet aggregation in pregnancy. Design A prospective descriptive study. Setting TCD Medical School, St James's Hospital, Dublin. Subjects Twenty healthy primigravidae who remained normotensive during pregnancy and the puerperium. Interventions 20 ml blood samples were obtained serially at 12, 20, 28, 32 and 36 weeks gestation, during established labour and at 1 h, 24 h, 48 h and 6 weeks after delivery. Main outcome measures Whole blood platelet aggregation in response to aggregating agents ADP, PAF (platelet aggregating factor) collagen, adrenaline and arachidonic acid (AA) at each stage of pregnancy and peuerperium was measured using a particle counting technique. The in vitro effect of aspirin and dazmegrel (thromboxane synthetase inhibitor UK38485) on platelet aggregation in pregnancy was also investigated. Results Platelet aggregation in response to collagen, adrenaline, ADP and AA were increased in the last trimester, during labour and at 1 h after delivery but decreased 24–48 h after delivery. Platelet aggregation in response to AA, collagen and adrenalin was reduced by both aspirin and dazmegrel. Conclusions The earliest and most marked increases in platelet aggregation during normal pregnancy were found in response to AA and collagen. These platelet changes were prevented when whole blood was pre‐incubated with either aspirin or dazmegrel. This suggests that enhanced production of TXA2 is reponsible for increased platelet reactivity in normal pregnancy.

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Section: Discussionsupporting

confidence: 72%

mentioning

confidence: 99%

Increased whole blood platelet aggregation in normal pregnancy can be prevented in vitro by aspirin and dazmegrel (UK38485)

Norris

Sheppard

Bonnar

1992

BJOG

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“…Some older previous studies have shown increased platelet aggregation induced by AA, ADP and COL in normal pregnancy (Morrison et al, 1985;Leuschen et al, 1986). In a small longitudinal study by Louden (1990), eight healthy pregnant women with normal pregnancy and delivery were compared with 12 healthy nonpregnant women regarding platelet aggregation, induced by AA, ADP and COL and analyzed with the Ultra-Flo 100 system.…”

Section: Paper IImentioning

confidence: 99%

Platelet aggregation in healthy women during normal pregnancy - a longitudinal study

et al. 2018

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Increased platelet activation is involved in obstetric complications such as preeclampsia and intrauterine growth retardation. It is of interest to study platelet aggregation during pregnancy, since increased aggregation theoretically could be a mechanism associated with placenta-mediated complications, which possibly could be prevented by drugs inhibiting platelet aggregation. There are, however, few robust studies describing platelet aggregation during normal pregnancy. The present longitudinal study was performed in order to study platelet aggregation during normal pregnancy resulting in a healthy child, during the puerperium and in nonpregnant, fertile women. Healthy, nonsmoking, pregnant women (n = 104), aged under 39 years and with BMI < 35, were followed during pregnancy and postpartum. Twenty-seven nonpregnant, non-puerperal, fertile women were studied for comparison. Platelet aggregation was determined with multiple electrode impedance aggregometry and analyzed at inclusion, 4 times during pregnancy and after at least 3 months postpartum. Platelet aggregation postpartum was compared with gestational weeks 8-15 and 37-40, respectively, and with nonpregnant, fertile women. Hemoglobin, leucocyte count, platelet count, prothrombin time, and activated partial thromboplastin time were determined at inclusion in order to verify normal hemostasis. Activation of platelets by arachidonic acid, adenosine diphosphate (ADP), and thrombin receptor activating peptide (trap-6) resulted in less aggregation during pregnancy, compared with postpartum (p < 0.03-< 0.001). Platelet aggregation following activation by collagen was unchanged. A minor increase in aggregation as pregnancy continued was found related to ADP (p < 0.021). Positive correlations were found between platelet counts and platelet aggregation. Postpartum platelet aggregation after activation with arachidonic acid, collagen, and trap-6 was lower than in the non-puerperal fertile state. Other hemostatic analyses were normal. In conclusion, there is a minor decrease in platelet aggregation after activation with arachidonic acid, trap-6, and ADP, measured with multiple electrode impedance aggregometry during normal pregnancy resulting in healthy babies, compared with the postpartum period. The small changes in platelet aggregation may be a consequence of a minor decrease in platelet count and probably lack clinical significance under normal conditions. Interindividual variations at certain time-points are substantial, which limits the usefulness of the multiple electrode impedance aggregometry for determining minor changes in platelet function.

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Drugs, Alcohol Abuse, and Effects in Pregnancy

and

Coustan

2007

Clinical Obstetrics

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Comparative evaluation of antepartum and postpartum platelet function in smokers and nonsmokers

Cited by 12 publications

References 10 publications

Increased whole blood platelet aggregation in normal pregnancy can be prevented in vitro by aspirin and dazmegrel (UK38485)

Increased whole blood platelet aggregation in normal pregnancy can be prevented in vitro by aspirin and dazmegrel (UK38485)

Platelet aggregation in healthy women during normal pregnancy - a longitudinal study

Drugs, Alcohol Abuse, and Effects in Pregnancy

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