Comparative evaluation of anti-inflammatory properties of thymoquinone and curcumin using an asthmatic murine model

Ammar, Elsayed M.; Gameil, Nariman M.; Shawky, Noha M.; Nader, Manar A.

doi:10.1016/j.intimp.2011.10.013

Cited by 71 publications

(41 citation statements)

References 27 publications

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“…Decreased TNF-a levels have also been noted in tumour-bearing animals treated with this polyphenol (Leyon and Kuttan, 2003). In addition to cancer, down-regulation of TNF-a by curcumin has been associated with protection from various pro-inflammatory diseases, including sub-chronic inflammation (Nandal et al, 2009;Nishida et al, 2010), cardiovascular diseases (Yao et al, 2004;Mito et al, 2011;Avci et al, 2012), diabetes (Jain et al, 2009;El-Azab et al, 2011;El-Moselhy et al, 2011), acute pancreatitis (Gulcubuk et al, 2006), enterocolitis (Jia et al, 2010), enteritis (Song et al, 2010), prostatitis (Zhang et al, 2010b), diabetic neuropathy (Sharma et al, 2007b), hepatic injury (Yun et al, 2010), Th1-type ileitis (Bereswill et al, 2010), hepatic fibrosis (Shu et al, 2007;Zeng et al, 2011), radiationinduced lung fibrosis , asthma (Ammar el et al, 2011), alcohol-induced liver disease (Nanji et al, 2003), non-alcoholic steatohepatitis (Ramirez-Tortosa et al, 2009), concanavalin A-induced liver injury (Tu et al, 2012), renal injury (Hashem et al, 2008;Pan et al, 2012), infection (Allam, 2009), fatigue (Gupta et al, 2009), bone turnover (Yang et al, 2011) and high-fat diet-induced hyperglycaemia (El-Moselhy et al, 2011). Curcumin has also been found to…”

Section: Suppression Of Tnf By Curcumin In Vivomentioning

confidence: 99%

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Aggarwal

Gupta

Sung

2013

British J Pharmacology

343

239

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TNFs are major mediators of inflammation and inflammation-related diseases, hence, the United States Food and Drug Administration (FDA) has approved the use of blockers of the cytokine, TNF-a, for the treatment of osteoarthritis, inflammatory bowel disease, psoriasis and ankylosis. These drugs include the chimeric TNF antibody (infliximab), humanized TNF-a antibody (Humira) and soluble TNF receptor-II (Enbrel) and are associated with a total cumulative market value of more than $20 billion a year. As well as being expensive ($15 000-20 000 per person per year), these drugs have to be injected and have enough adverse effects to be given a black label warning by the FDA. In the current report, we describe an alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable and highly safe in humans, yet can block TNF-a action and production in in vitro models, in animal models and in humans. In addition, we provide evidence for curcumin's activities against all of the diseases for which TNF blockers are currently being used. Mechanisms by which curcumin inhibits the production and the cell signalling pathways activated by this cytokine are also discussed. With health-care costs and safety being major issues today, this golden spice may help provide the solution. LINKED ARTICLESThis article is part of a themed section on Emerging Therapeutic Aspects in Oncology. To view the other articles in this section visit http://dx

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Section: Suppression Of Tnf By Curcumin In Vivomentioning

confidence: 99%

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Aggarwal

Gupta

Sung

2013

British J Pharmacology

343

239

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“…There seeds, also known as black cumin, are generally used in the Middle East, India and North Africa for medicinal purposes as a natural remedy against a number of diseases including bronchial asthma, rheumatism, hypertension, diabetes, inflammation, cough, headaches, eczema, fever and flu (Burits and Bucar 2000; Salem 2005). Thymoquinone (TQ) is the most important component pharmacologically present in the essential oil of these seeds (Amm et al 2011), with an important antioxidant power (Rifaioglu et al 2013) which allows it to keep many organs opposed to oxidative damage beget by various free radical (Yaman and Balikci 2010). Having regard to the low toxicity of its oil highlighted by high values LD 50 = 28.8 ml/kg (Ghedira and Le jeune 2010), this suggests a significant therapeutic range.…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective and Diuretic Effect of Nigella Sativa L Seeds Oil on Lithiasic Wistar Rats

Benhelima¹,

Kaid-Omar²,

Hemida³

et al. 2016

AJTCAM

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Background and objective: The purpose of the current investigation was to study the influences, preventive and diuretic, of Nigella sativa L. seeds oil (NSSO) on calcium oxalate (CaOx) urolithiasis induced in Wistar male rats. Methodology: Seeds of Nigella sativa L. (N.S) were analysed for the evaluation of the concentration of oxalate and calcium. Nigella sativa L. seeds oil is obtained by hydrodistillation and HPTLC densitometric method was adopted to determine the amount of thymoquinone (TQ) present. Thirty male Wistar rats were divided into 5 groups (N=6). Group I, negative control, drank tap water. The other groups were II Positive control, III, IV and V received a treatment model inducing calcium oxalate urolithiasis for 28 days, using an aqueous solution involve 0.75% (EG) ethylene glycol and 1.0 % (AC) chloride ammonium. Rats in group III received in addition, 750 mg/kg Cystone from the beginning to the end of calculi induction experimentation. However, rats in Groups IV and V received (NSSO) at 5 ml/kg b.w by gavage on days 1 st to 28 th and 15 th to 28 th days, respectively. On days 0, 7, 14, 21 and 28, body weights were measured and the 24-hour urine samples were accumulated and analysed for biochemical elements. On the 28 th day, blood samples were collected for the estimation of serum parameters including creatinine, BUN and uric acid. All animals were sacrificed at the end of the experiment and the kidneys were detached for histopathological examination. Results: Administration of (NSSO) at 5 ml/kg body weight/dose/day for 28 days exerts a protective effect by reducing significantly (p <0.01) urinary and serum rates of calcium, phosphate and oxalate. This preventive diet could increase the volume of urine excreted. Conclusion:The nephroprotectrice and diuretic activity demonstrated by Nigella sativa L. gives a scientific basis that approves their traditional use like a remedy against urolithiasis.

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“…No earlier work evaluated the effect of thymoquinone in allergic rhinitis, but a few studies on its effects on other allergic diseases have been published [8,9,10,11,12]. Besides, thymoquinone has a very low toxicity, and a few cases of contact dermatitis have been reported after its use; otherwise, no adverse effects are listed [21].…”

Section: Discussionmentioning

confidence: 99%

“…A few studies have shown that thymoquinone exerts anti-inflammatory effects in patients with certain allergic diseases, including asthma, food allergies, and allergic conjunctivitis [8,9,10,11,12], but its effect on allergic rhinitis remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Histopathological Effects of Thymoquinone and Local Nasal Corticosteroids in Allergic Rhinitis in a Rabbit Model

Yurttaş

Şereflican

Erkoçoğlu³

et al. 2016

ORL

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Background/Aims: In this study, we aimed to evaluate the histopathological effects of thymoquinone treatment of the nasal mucosa in a rabbit model of allergic rhinitis, and we compared its effects with those of nasal mometasone furoate. Methods: A total of 24 male New Zealand rabbits were used. The animals were randomly assigned to one of four groups. Group 1 received no treatment, while group 2 underwent ovalbumin (OVA) sensitization only. Group 3 was the study group; after OVA sensitization, the rabbits were treated with intranasal thymoquinone. The group 4 rabbits received mometasone furoate for 7 days after OVA sensitization. Mucosal structures were stained with hematoxylin and eosin, while toluidine blue was used to stain mast cells. Apoptosis was evaluated using a TUNEL assay. Results: In the positive control groups, including the thymoquinone and intranasal mometasone furoate groups, intraepithelial and submucosal inflammation and goblet cell hypertrophy were significantly decreased compared to group 2 (p < 0.001). The cilial structure was normal, as was the chondrocyte structure in both treatment groups. Conclusion: This is the first study to evaluate the histopathological effects of thymoquinone in an allergic rhinitis model. Thymoquinone reduced allergic inflammation and may be valuable for treating allergic rhinitis. However, additional studies are needed.

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Comparative evaluation of anti-inflammatory properties of thymoquinone and curcumin using an asthmatic murine model

Cited by 71 publications

References 27 publications

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Nephroprotective and Diuretic Effect of Nigella Sativa L Seeds Oil on Lithiasic Wistar Rats

Comparison of Histopathological Effects of Thymoquinone and Local Nasal Corticosteroids in Allergic Rhinitis in a Rabbit Model

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