Comparative evaluation of anti-plaque efficacy of herbal and 0.2% chlorhexidine gluconate mouthwash in a 4-day plaque re-growth study

Abstract

Background:Chlorhexidine gluconate mouthwash has earned eponym of gold standard to treat and/or prevent periodontal disease. However, it has been reported to have local side-effects on long-term use. To explore a herbal alternative, the present study was carried out with an aim to compare the anti-plaque efficacy of a herbal mouthwash with 0.2% chlorhexidine gluconate mouthwash and normal saline.Materials and Methods:It was an examiner-blinded, parallel designed clinical trial, in which 90 pre-clinical dental students with gingival index (GI) ≤1 were enrolled. To begin with, GI and plaque index (PI) were recorded. Then, baseline plaque scores were brought to zero by professionally cleaning the teeth with scaling and polishing. After that, randomized 3 groups were made (of 30 subjects each - after excluding the drop-outs) who were refrained from regular mechanical oral hygiene measures. Subjects were asked to swish with respective mouthwash (0.2% chlorhexidine gluconate mouthwash, herbal mouthwash, or normal saline) as per therapeutic dose for 4 days. Then, GI and PI scores were re-evaluated on 5th day by the same investigator, and the differences were compared statistically by ANOVA and Student's ‘t’-test.Results and Observations:Least post-rinsing GI and PI scores were demonstrated with 0.2% chlorhexidine gluconate mouthwash, followed by herbal mouthwash and highest scores with normal saline. The difference of post-rinsing PI scores between the chlorhexidine and herbal mouthwash groups was statistically non-significant, whereas this difference was significant between chlorhexidine and saline groups, and the difference between herbal and saline groups was non-significant. It was concluded that 0.2% chlorhexidine gluconate mouthwash remains the best anti-plaque agent. However, when socio-economic factor and/or side-effects of chlorhexidine need consideration, presently tested herbal mouthwash may be considered as a good alternative.

Chemical Plaque Control Strategies in the Prevention of Biofilm-associated Oral Diseases

“…63 Aloe vera gel consists of 98 to 99% water and the remaining 1 to 2% of active compounds. The main active ingredients in aloe vera gel are aloin, aloeemodin, aloemannan, acemannan, aloeride, naftoquinones, methylchromones, flavonoids, saponin, sterols, amino acids, and vitamins.…”

Cymbopogon citratus essential oil: effect on polymicrobial caries-related biofilm with low cytotoxicity

“…6,7 Chlorhexidine digluconate is considered the gold standard antimicrobial substance. 8 Nonetheless, the occurrence of adverse effects, such as dental staining and hypersensitivity reactions, has encouraged the search for new molecules. 8 The promising potential of natural substances against cariogenic microorganisms, and their application in the development of preventive and therapeutic products, has been explored in recent years.…”

“…8 Nonetheless, the occurrence of adverse effects, such as dental staining and hypersensitivity reactions, has encouraged the search for new molecules. 8 The promising potential of natural substances against cariogenic microorganisms, and their application in the development of preventive and therapeutic products, has been explored in recent years. 9,10 There are already some commercially available formulations of mouthwashes and dentifrices containing natural substances.…”

Impact of Mouthwashes on Antibacterial Activity of Subjects with Fixed Orthodontic Appliances: A Randomized Clinical Trial

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