Comparative evaluation of antidiabetic activity of Rosmarinus officinalis L. and Chamomile recutita in streptozotocin induced diabetic rats

Abstract

Herbal formulations are getting more importance in the treatment of diabetes, cancer and hepatic disorder because of the hazardous adverse effects of the current therapy. Especially diabetes can be controlled by Allopathic medicine as well as Herbal medicine. A comparison was made between the antidiabetic activities of water extracts of leaves of Rosmarinus Officinalist and Chamomile recutitain Streptozotocin-induced diabetic rats. Serum Fasting blood glucose and other biochemical parameters such as total protein; carbohydrate hydrolyzing enzyme; α -amylase, total antioxidant capacity, liversteoteosis; total cholesterol, Triacylglycerol, were determined at the dose 200 mg/kg body weight for 21 days. There is a significant increase decrease in serum fasting blood glucose (p<0.001) , increase in body weight and improvement in the other biochemical parameters with treatment of herbal formulations which altered in diabetic rats There was a significant decrease in serum glucose level (p<0.001), increase in body weight and changes in normal cells was observed with treatment of the above mentioned extracts which altered in diabetic rats as compared to the control rats standard.

Evaluation of Hypoglycemic Activity of Boswellia Carterii and Cissus Rotundifolia in Streptozotocin/Nicotinamide-Induced Diabetic Rats

“…In the present study, reduced mean body weight in STZ/NA-induced diabetic rats might be attributed to the increased muscle wasting and degradation of structural proteins due to carbohydrate unavailability as an energy source (29). This finding agrees with previous observations that have also reported loss of body weight (5,32).…”

“…STZ induces rapid and irreversible β-cell necrosis as a result of free radical generation, leading to a massive reduction in these insulinsecreting cells (29). Increased levels of ROS in βcells may lead to DNA damage by oxidation, and therefore, to their destruction by necrosis (6).…”

Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation

“…Rosemary ( Rosmarinus officinalis Lamiaceae ) is an aromatic evergreen shrub/plant indigenous to the Mediterranean region and South America reported to have anti‐diabetic properties. In in vivo studies, rosemary extract administration decreased plasma glucose levels in streptozotocin and alloxan chemically‐induced diabetic animals as well as in dietary, high fat diet‐induced, animal models of obesity and insulin resistance …”

“…Rosemary (Rosmarinus officinalis Lamiaceae) is an aromatic evergreen shrub/plant indigenous to the Mediterranean region and South America reported to have anti-diabetic properties. In in vivo studies, rosemary extract administration decreased plasma glucose levels in streptozotocin and alloxan chemically-induced diabetic animals [11][12][13][14] as well as in dietary, high fat diet-induced, animal models of obesity and insulin resistance. 15,16 In a recent study, we examined the direct effects of RE on skeletal muscle cells and found a significant increase in glucose uptake and activation of AMPK 17 which may explain some of its in vivo blood glucose lowering effects.…”

Immunohistochemical Study of the Effect of Chamomile Extract on 5-Fluorouracil Induced Intestinal Mucositis in Albino Rats

“…In the distilled water treated group, a volume of distilled water equal to chamomile extract was given by intragastric gavage tube, while the chamomile extract-treated group was gavaged with chamomile extract (Matricaria recutita organic alcoholic extract-United States-Code HS3751002) at a dose of (100 mg/ kg) two times daily [23]. The animals were intraperitoneally injected by normal saline in the same manner and dose like 5-FU on day 0 and 2, and the treatment with distilled water or the chamomile extract was initiated on day 5 and the experiment continued for twelve days.…”