Comparative evaluation of antimicrobial activity of different types of ionic liquids

Florio, Walter; Becherini, Stefano; D’Andrea, Felicia; Lupetti, Antonella; Chiappe, Cinzia; Guazzelli, Lorenzo

doi:10.1016/j.msec.2019.109907

Cited by 61 publications

(37 citation statements)

References 67 publications

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“…The length and the number of alkyl chains in the molecule is the main factor determining the antimicrobial activity of ILs [ 63 ]. The “ideal” length should be of 12 or 14 carbon atoms, as this range of lengths showed the highest antimicrobial activity, whereas aliphatic chains of over 16 or less than 10 carbon atoms showed a reduction in antimicrobial activity [ 46 , 63 ]. Another important feature of ILs is their chemical structure, in particular the presence of polar groups in the hydrophilic part of the IL.…”

Section: Ionic Liquids and Active Pharmaceutical Ingredients (Apismentioning

confidence: 99%

“…Another important feature of ILs is their chemical structure, in particular the presence of polar groups in the hydrophilic part of the IL. This will affect the antimicrobial activity significantly, as demonstrated for imidazolium, pyridinium, and pyrrolidinium type ILs [ 63 , 64 ].…”

Section: Ionic Liquids and Active Pharmaceutical Ingredients (Apismentioning

confidence: 99%

“…Cole et al [ 63 ] also proposed recycling antibiotics with ILs or organic salts. In their work, they used ampicillinate, carbenicillinate, cephalothinate, and oxacillinate as anions and tested against resistant strains, with their results showing a promising approach to combatting antibiotics resistance [ 63 ].…”

Section: Ionic Liquids and Active Pharmaceutical Ingredients (Apismentioning

confidence: 99%

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Recycling Old Antibiotics with Ionic Liquids

et al. 2020

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Antibiotics are considered one of the great “miracles” of the 20th century. Now in the 21st century in the post-antibiotic era, the miracle is turning into a nightmare, due to the growing problem of the resistance of microorganisms to classic antimicrobials and the non-investment by the pharmaceutical industry in new antimicrobial agents. Unfortunately, the current COVID-19 pandemic has demonstrated the global risks associated with uncontrolled infections and the various forms of impact that such a pandemic may have on the economy and on social habits besides the associated morbidity and mortality. Therefore, there is an urgent need to recycle classic antibiotics, as is the case in the use of ionic liquids (ILs) based on antibiotics. Thus, the aim of the present review is to summarize the data on ILs, mainly those with antimicrobial action and especially against resistant strains. The main conclusions of this article are that ILs are flexible due to their ability to modulate cations and anions as a salt, making it possible to combine the properties of both and multiplying the activity of separate cations and anions. Also, these compounds have low cost methods of production, which makes it highly attractive to explore them, especially as antimicrobial agents and against resistant strains. ILs may further be combined with other therapeutic strategies, such as phage or lysine therapy, enhancing the therapeutic arsenal needed to fight this worldwide problem of antibacterial resistance. Thus, the use of ILs as antibiotics by themselves or together with phage therapy and lysine therapy are promising alternatives against pathogenic microorganisms, and may have the possibility to be used in new ways in order to restrain uncontrolled infections.

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Section: Ionic Liquids and Active Pharmaceutical Ingredients (Apismentioning

confidence: 99%

Section: Ionic Liquids and Active Pharmaceutical Ingredients (Apismentioning

confidence: 99%

Section: Ionic Liquids and Active Pharmaceutical Ingredients (Apismentioning

confidence: 99%

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Recycling Old Antibiotics with Ionic Liquids

et al. 2020

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“…Furthermore, the urgent need to evaluate the antibacterial properties of ILs has also been noticed, in order to screen for new substances with potential pharmacological value that may represent a better alternative to traditional treatment and an advantage regarding the constant increment of antimicrobial resistances that hampers the treatment of several infections. The ability to inhibit the growth of several pathogens has been detected for several common imidazolium, pyridinium, ammonium, piperidinium and pyrrolidiniumbased ILs, among others [22,[24][25][26][27][28][29][30]. Moreover, it is well known that the increment of the alkyl side chain length plays a major role in the antimicrobial potency of ILs, which can be related to a mechanism of cell membrane disruption boosted by the higher hydrophobicity associated with longer alkyl chains-based compounds [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

“…The ability to inhibit the growth of several pathogens has been detected for several common imidazolium, pyridinium, ammonium, piperidinium and pyrrolidiniumbased ILs, among others [22,[24][25][26][27][28][29][30]. Moreover, it is well known that the increment of the alkyl side chain length plays a major role in the antimicrobial potency of ILs, which can be related to a mechanism of cell membrane disruption boosted by the higher hydrophobicity associated with longer alkyl chains-based compounds [27][28][29][30]. However, the introduction of hydroxyethyl groups in the IL side chain causes a reduction of the antimicrobial activity [30,31].…”

Section: Introductionmentioning

confidence: 99%

Ecotoxicity and Hemolytic Activity of Fluorinated Ionic Liquids

Vieira¹,

Oliveira²,

Araújo³

et al. 2021

Sustainable Chemistry

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The task-specific design of ionic liquids (ILs) has emerged in several industrial and pharmaceutical applications. The family of ILs with fluorine tags equal to or longer than four carbon atoms, the fluorinated ionic liquids (FILs), combine the best properties of ILs with the ones of perfluorinated compounds, and are being designed for several specific purposes. In the pharmaceutical field, there is an urgency to search for novel antibacterial agents to overcome problems associated to antimicrobial resistances. Then, the main purpose of this work is to evaluate the environmental impact and the ability of FILs to be used as antibacterial agents against Pseudomonas stutzeri bacteria. Beyond its rare pathogenicity, these bacteria are also used as a bioremediation agent to treat several contamination sites. Then, it is important to determine which FILs have antibacterial properties, and which do not impact the bacterial growth. The biocompatibility of FILs was also evaluated through their hemolytic activity and represent a step forward the application of FILs in pharmaceutical applications. The results proved that high concentrations of FILs can have a reduced ecotoxicity and a high biocompatibility. [C8C1Im][CF3SO3] was identified as the most promising compound to be used as an antibacterial agent since it prevents the growth of bacteria at concentrations compatible with the red blood cells’ viability.

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How Environmental Chemicals of Concern Emerge: ILs and HNTs

Nelson

2023

Challenges and Advances in Computational Chemistry and Physics

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Comparative evaluation of antimicrobial activity of different types of ionic liquids

Cited by 61 publications

References 67 publications

Recycling Old Antibiotics with Ionic Liquids

Recycling Old Antibiotics with Ionic Liquids

Ecotoxicity and Hemolytic Activity of Fluorinated Ionic Liquids

How Environmental Chemicals of Concern Emerge: ILs and HNTs

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