Comparative evaluation of antioxidant capacities of thiol-based antioxidants measured by different in vitro methods

Güngör, Nilay; Özyürek, Mustafa; Güçlü, Kubilay; Çekiç, Sema Demirci; Apak, Reşat

doi:10.1016/j.talanta.2010.11.048

Cited by 57 publications

(26 citation statements)

References 25 publications

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“…Nevertheless, while FRAP assay requires an acidic pH (3.6), that is far from the physiological pH value, CUPRAC assay is performed at pH 7.0, simulating better the physiological conditions. In addition, CUPRAC assay differentiates the reducing power of thiol-type antioxidants (Apak et al, 2004;Güngör et al, 2011).…”

Section: Capacity Of Antioxidants To Reduce Metal Ions (Frap and Cuprmentioning

confidence: 99%

Asteraceae species with most prominent bioactivity and their potential applications: A review

Bessada

Barreira

Oliveira

2015

Industrial Crops and Products

134

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a b s t r a c tOxidative stress has a relevant part in the etiology of several diseases and metabolic disorders, being reasonable to expect that antioxidant compounds might have beneficial effects in health maintenance or disease prevention. Antioxidant compounds might be isolated and characterized from different plant constituents, such as roots, stems, bark, leaves, flowers, fruits and seeds, using proper extraction methods. The Asteraceae family has a worldwide distribution, with special relevance in the Mediterranean, Eastern Europe and Asia Minor, being acknowledged about 25 000 species integrated in approximately 1000 genera. In addition to the anti-inflammatory, analgesic and antipyretic potential of some of these species, their high antioxidant power, as proven in research works with extracts (of roots, stems, bark, leaves, flowers, fruits and seeds) should be highlighted. Herein, the Asteraceae species with highest potential as sources of natural antioxidants with potential uses in medicine and in pharmaceutical, cosmetic and food industries were identified. The species were selected based on their botanical representativeness, being identified the 9 most relevant species: Achillea millefolium L., Acmella oleraceae Murr., Artemisia absinthium L., Bidens pilosa L., Carthamus tinctorius L., Inula crithmoides L., Matricaria recutita L., Otanthus maritimus L. and Parthenium hysterophorus L.. With the obtained information, it could be concluded that the bioactivity of the selected Asteraceae species lacks a complete characterization, constituting a research scope with great potential to be exploited in the development of dietary supplements, bioactive food ingredients or pharmaceutical based products with application in food industry, dermocosmetics or medicine.

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Section: Capacity Of Antioxidants To Reduce Metal Ions (Frap and Cuprmentioning

confidence: 99%

Asteraceae species with most prominent bioactivity and their potential applications: A review

Bessada

Barreira

Oliveira

2015

Industrial Crops and Products

134

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“…The absence of significant changes of total antioxidant capacity and glutathione activity in our study could be, at least partly, explained with methodological issues. Researchers reported that different assays used for detection of these antioxidative markers (including those used in our research) could have different diagnostic performances (Cighetti et al 2015, Güngör et al, 2011. Consequently, we could not exclude the possibility that the laboratory assays used in our study for these two analytes gave false-negative results, particularly if their changes were of small magnitude.…”

Section: Resultsmentioning

confidence: 83%

Effects of L-Ascorbic Acid and Alpha-Tocopherol on Biochemical Parameters of Swimming-Induced Oxidative Stress in Serum of Guinea Pigs

Bursać-Mitrović¹,

Мilоvаnоvić²,

Mitić³

et al. 2016

Afr J Tradit Complement Altern Med

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Background: The purpose of this study is to determine the effect of L-ascorbic acid and alpha-tocopherol as well as combination of these vitamins with or without exposure to physical exercise on intensity of lipid peroxidation, activity of xanthine oxidase, activity of total antioxidative system, concentration of glutathione, and activity of catalase in the serum of guinea pigs. Materials and Methods: The experimental measurements of intensity of lipid peroxidation, activity of xanthine oxidase, activity of total antioxidative system, concentration of glutathione, and activity of catalase were done in the serum of guinea pigs. The animals were exposed to the test load to achieve exhaustion and the test was terminated when the animal for the third time to sink into the water. Results:The results of this study demonstrated that endurance exercise of guinea pigs induced oxidative stress response in terms of increased lipid peroxidation and activity of xanthine oxidase in the serum of experimental animals. Our study investigated the antioxidant activity of L-ascorbic acid and alpha-tocopherol also measuring three protective markers in the serum: total antioxidant activity, content of glutathione and activity of catalase. The results obtained show that the vitamins influence the concentrations of above mentioned biochemical parameters, which points out their protective effect of swimming-induced oxidative stress. Conclusion: Single or combined administration of L-ascorbic acid and alpha-tocopherol caused significant inhibition of these markers indicating the important antioxidant activity of the vitamins. Results lead to conclude that the combined treatments with vitamins with or without exposure to physical exercise showed the clear synergistic effect..

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“…It then generates the cuprous form [Cu(I)-Nc] and displays a maximum light absorption of 450 nm (Güngör et al, 2011). Güngör et al (2011) compared the methods used to determine antioxidant activities of thiol based antioxidants and concluded that the most proper method for thiols was CUPRAC. They also concluded that the results obtained by the FRAP method were not consistent, even in the samples with a high GSH content.…”

Section: Resultsmentioning

confidence: 99%

Comparative study of functional properties of eight walnut (Juglans regia L.) genotypes

et al. 2017

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Comparative evaluation of antioxidant capacities of thiol-based antioxidants measured by different in vitro methods

Cited by 57 publications

References 25 publications

Asteraceae species with most prominent bioactivity and their potential applications: A review

Asteraceae species with most prominent bioactivity and their potential applications: A review

Effects of L-Ascorbic Acid and Alpha-Tocopherol on Biochemical Parameters of Swimming-Induced Oxidative Stress in Serum of Guinea Pigs

Comparative study of functional properties of eight walnut (Juglans regia L.) genotypes

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