Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis

Hosseini, Sare; Soltani‐Zangbar, Mohammad Sadegh; Zamani, Majid; Yaghoubi, Yoda; Ghiasi, Reza Rikhtegar; Motavalli, Roza; Ghassabi, Ali; Iranzad, Rahim; Mehdizadeh, Amir; Shakouri, Seyed Kazem; Pishgahi, Alireza; Yousefi, Mehdi

doi:10.1080/08977194.2023.2227273

Cited by 7 publications

(5 citation statements)

References 44 publications

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“…Manuscripts were published between 2015 and 2023. According to the Cochrane Risk of Bias 2 Tool for Randomised Controlled Studies, one reported as an overall judgement "Some concerns" [24] an another "Low" [25]; with the ROBINS-I tool for non-randomised study obtained a judgement of "Some Concerns" [23]. The SYRCLE evaluating score system for animal studies showed that one study achieved 3/18 points [20], other one achieved 4/18 points [21] another 5/18 points [19] and 6/18 points [22].…”

Section: Selection Resultsmentioning

confidence: 99%

“…Hosseini et al demonstrated that PL may in fact perform better than PRP in patients with knee OA [24]. Interestingly, the significant difference in scores for PL versus PRP were noted only at 6 months-none of the tested values in fact had a significant difference between PL and PRP at the 1-month assessment.…”

Section: Discussionmentioning

confidence: 98%

“…Hosseini et al [24] prepared PL from 20 mL of blood, which was drawn from each patient in sterile citrate tubes. After serial centrifugation, the platelet pellet was resuspended in physiologic saline (0.9% sodium chloride) in order to eliminate likely contaminants with plasma reaching a final platelet concentration of about 1 × 10 7 platelets/μL.…”

Section: Pl Preparationmentioning

confidence: 99%

“…This study was given a low confidence score due to its risk of bias, and the way the study was conducted, which is elaborated in the discussion. Hosseini et al [24] in a recent article performed an RCT comparing the efficacy of PRP and PL. The study consisted of 25 female patients between the ages of 38-67, suffering from OA in both knees.…”

Section: Human Studiesmentioning

confidence: 99%

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Platelet lysate for the treatment of osteoarthritis: a systematic review of preclinical and clinical studies

Valtetsiotis,

Di Martino,

Brunello

et al. 2024

Musculoskelet Surg

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Intra-articular injection-based therapy is often used aside conservative treatment and lifestyle modifications to manage knee osteoarthritis (KO) patients. Conventional injections contain steroids and hyaluronic acid, while more recently multipotential adult stem cell, platelet-rich plasma (PRP), and platelet lysate (PL) injections have been used to promote cartilage regeneration or repair. The aim of the current study is to analyse current evidence on PL injections for the treatment of KO and to determine if these are effective and how these perform compared to other injection regimens. The databases of Scopus, Embase, PubMed, Web of Science, and Cochrane Library were searched on 30 June 2023. Risk of bias was assessed using the SYRCLE tool for animal studies and Cochrane RoB 2 as well as ROBINS-I tool for human studies. Studies were included if these were in English, any year, and regarded animals with osteoarthritis (OA) or human adult patients with OA. In vitro trials and non-adult human studies were excluded. Results on OA symptom stage and severity, and pain were recorded. The research retrieved three human studies (n = 48, n = 25, n = 58) and four animal studies: one rabbit, two studies, and one rat study. PL was found to decrease KO symptoms at follow-up ≤ 1 year with respect to baseline levels and when compared to hyaluronic acid or platelet-rich plasma. Symptoms returned 6 months–1 year after the final administration, with studies showing peak efficacy at approximately 6 months. Animal studies showed clinical improvements, reduction of lameness, and partial effect on the cartilage regeneration of the seven studies, two had a high risk of bias, four were associated to some concerns, and one had low risk. A major source of bias in these studies was the use of questionnaires and scoring that could be subject to interpretation. Overall, PL was well-tolerated and showed efficacy comparable to PRP; when pain control was assessed, it showed similar efficacy compared to hyaluronic acid. These findings may support its use in clinical trials to confirm these initial findings; future research should also focus on the comparison with other non-surgical treatments, on a more detail of the potential regenerative properties, and to optimise the treatment schedule.

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Section: Selection Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Pl Preparationmentioning

confidence: 99%

Section: Human Studiesmentioning

confidence: 99%

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Platelet lysate for the treatment of osteoarthritis: a systematic review of preclinical and clinical studies

Valtetsiotis,

Di Martino,

Brunello

et al. 2024

Musculoskelet Surg

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“…Conversely, Xiong et al [ 2 ] in an up-to-date systematic review and meta-analysis reported that leukocyte-poor PRP was significantly effective in reducing pain in knee OA patients, whereas leukocyte-rich PRP was not. These contentious outcomes have led researchers and clinicians to explore alternative APBOs for the management of knee OA[ 3 - 11 ]. Different types of APBOs along with the most recent clinical evidence are summarized in Table 1 .…”

Section: Apbomentioning

confidence: 99%

Autologous peripheral blood-derived orthobiologics: Different types and their effectiveness in managing knee osteoarthritis

Gupta,

Jain

2024

World J Orthop

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Knees are the most commonly impacted weight-bearing joints in osteoarthritis (OA), affecting millions of people worldwide. With increasing life spans and obesity rates, the incidence of knee OA will further increase, leading to a significant increase in the economic burden. Conventional treatment modalities utilized to manage knee OA have limitations. Over the last decade, the role of various autologous peripheral blood-derived orthobiologics (APBOs) for the treatment of knee OA has been extensively investigated. This editorial provided an overview and focused on defining and shedding light on the current state of evidence based on the most recent published clinical studies concerning the use of APBO for the management of knee OA. While numerous studies have demonstrated promising results for these preparations, a notable gap exists in the comparative analysis of these diverse formulations. This absence of head-to-head studies poses a considerable challenge for physicians/surgeons in determining the optimal preparation for managing knee OA and achieving sustained long-term results. Thus, more adequately powered, multicenter, prospective, double-blind, randomized controlled trials with longer follow-ups are needed to establish the long-term efficacy and to aid physicians/surgeons in determining the optimal APBO for the management of knee OA.

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Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence

Gupta,

Maffulli

2024

Pain Ther

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Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis

Cited by 7 publications

References 44 publications

Platelet lysate for the treatment of osteoarthritis: a systematic review of preclinical and clinical studies

Platelet lysate for the treatment of osteoarthritis: a systematic review of preclinical and clinical studies

Autologous peripheral blood-derived orthobiologics: Different types and their effectiveness in managing knee osteoarthritis

Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence

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