Comparative evaluation of bioactive glass bone graft material with platelet rich fibrin and bioactive glass bone graft material alone for the treatment of periodontal intrabony defects: a clinical and radiographic study

Ashawan, Prashant John; Zade, R. M.

doi:10.18203/2320-6012.ijrms20162281

Cited by 4 publications

(7 citation statements)

References 9 publications

(16 reference statements)

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“…The present study was a split‐mouth randomized controlled trial which evaluated the clinical efficacy of new generation BG morsels and its combination with PRF in the treatment of periodontal intrabony defects in patients with chronic periodontitis and showed a significant improvement in clinical and radiographic parameters. No clinical evidences of undesirable local and systemic responses were detected and these findings were in agreement with those of Ashawan et al . and Grover et al .…”

Section: Discussionsupporting

confidence: 92%

“…Similar results have been reported by Cortellini and Tonetti, who concluded that in deeper defects (4 mm or more), a greater CAL gain is achieved . Findings of the present study are in contrary to results of Ashawan et al., wherein those authors reported statistically non‐significant difference in CAL for sites treated with BG+PRF and BG alone. The difference can be attributed to the selection geometry of the defects and method of evaluation for regeneration.…”

Section: Discussionsupporting

confidence: 69%

“…The difference can be attributed to the selection geometry of the defects and method of evaluation for regeneration. Ashawan et al., evaluated regeneration on digital radiographs, which being a two‐dimensional evaluation imaging technique, have several limitations. In our study, the evaluation was carried out by the technique of CBCT analysis, which is known to be more precise in such evaluations .…”

Section: Discussionmentioning

confidence: 99%

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Clinical and radiographic evaluation and comparison of bioactive bone alloplast morsels when used alone and in combination with platelet‐rich fibrin in the treatment of periodontal intrabony defects—A randomized controlled trial

Bodhare

Kolte

et al. 2018

Journal of Periodontology

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Background: The present study aims to evaluate and compare the clinical and radiographic changes obtained through Bioactive Glass (BG) with and without autologous platelet-rich fibrin (PRF) in the treatment of intrabony defects in chronic periodontitis patients. Methods:The present study was a split-mouth randomized controlled clinical trial comprising 20 chronic periodontitis patients (mean age: 35.9 years) having at least one pair of bilateral intrabony defect. Group 1 included 20 sites treated with a combination of BG and autologous PRF whereas 20 sites in Group 2 were treated with BG alone. Probing pocket depth (PPD), clinical attachment level (CAL) and gingival recession (GR) were evaluated at 3 and 6 months and bone fill at 6 months by using cone beam computed tomography (CBCT) analysis. Primary study outcomes were changes in PPD, CAL, GR, and bone fill.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

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Clinical and radiographic evaluation and comparison of bioactive bone alloplast morsels when used alone and in combination with platelet‐rich fibrin in the treatment of periodontal intrabony defects—A randomized controlled trial

Bodhare

Kolte

et al. 2018

Journal of Periodontology

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“…These results are in accordance with those of Pradeep et al,(31) Ashawan et al, (32) and Agrawal el al, (33). However , all these authors used gingival index (GI)(26) rather than modified gingival index (MGI) (27), which was preferred in this study for its non-invasiveness.…”

Section: Plaque Index Pisupporting

confidence: 91%

The Efficacy of Combining Advanced Platelet-Rich Fibrin to Biphasic Alloplast in Management of Intrabony Defects (Randomized Controlled Clinical Trial)

Ghonima

Rashidy

Kotry

et al. 2020

Alexandria Dental Journal

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INTRODUCTION:Advanced platelet-rich fibrin (A-PRF) is one of the most recently developed platelet concentrates and believed to have a great impact in regeneration for its richness in leukocytes, platelets, stem cells and cytokines. Biphasic calcium phosphate (BCP) alloplast is a well-known synthetic bone substitute widely used in periodontal regeneration. OBJECTIVES: To evaluate the additive effect of A-PRF to BCP in regeneration of intrabony defects. MATERIALS AND METHODS: Twenty two interproximal, intrabony defects in 22 patients with moderate to severe chronic periodontitis were allocated to one of the two groups of this study. Group I (test) was treated with open flap debridement followed by placing A-PRF and BCP with a ratio of 1:1, while group II (control) was filled only by BCP mixed with saline after open flap debridement (OFD). Plaque index (PI), modified gingival index (MGI), probing depth (PD) and clinical attachment level (CAL) were evaluated at baseline, 3, 6 and 9 months. RESULTS: Compared to baseline all evaluated parameters showed improvement at the end of the study in both groups. Changes from baseline to 9 months in A-PRF/BCP group were insignificantly greater compared to BCP/saline group regarding reduction of PI (0.54±0.72 vs 0.53±0.92), MGI (0.34±0.68 vs 0.32±0.78), PD (2.27±0.71mm vs 2.04±0.96mm) and CAL gain (2.13±1.02mm vs 1.68±1.23mm). However, intergroup differences were insignificant. CONCLUSIONS: Based on results of this study, combining advanced platelet-rich fibrin to biphasic alloplast mixture was more advantageous than using BCP alone in intrabony defect management.

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“…It has been widely known that periodontal therapy aims to regenerate damaged periodontal tissue, including periodontal ligament function, alveolar bone, and cementum. 1 Scaling and root planning (SRP) and open flap debridement (OFD) surgery are the treatment of choice to eliminate pockets and repair periodontal tissue. 2 Infrabony pocket is one feature of periodontal tissue damage, characterized by the higher appearance of apical pocket basal compared to the adjacent alveolar bone and the presence of vertical bone damage.…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of injectable platelet-rich fibrin and bone graft addition to open flap debridement for infrabony pocket therapy

Dindarini

Herawati

Lastianny

2022

Majalah Kedokteran Gigi Indonesia

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Various biomaterials have been utilized as additional material to help tissue regeneration in the open flap debridement (OFD) procedure. Platelet-rich fibrin (PRF) is an autologous platelet concentrate that contains many growth factors (GFs) and generally used as an additional biomaterial in OFD. However, PRF has several weaknesses, such as its consistency, which is hard to mix with another biomaterial, and its abundant sediment of regenerative cells resulted from high-speed centrifugation. Injectable Platelet Rich Fibrin (I-PRF) is one of the PRF derivatives that contain more regenerative cells. Due to the low-speed centrifugation, I-PRF has a liquid form. Certain GFs were also found in I-PRF, such as PDGF, TGF-β1, VEGF, IGF, EGF dan COL-Ia. In this study, we measured probing depth (PD), relative attachment level (RAL), and bone height as the healing parameter, to see the effectiveness of I-PRF addition and bone graft in the OFD for infrabony pocket as the aim of this study. Twenty (20) periodontal pockets were chosen (PD= 5-7 mm) and divided into OFD+I-PRF+bone graft (bg) group (group I) and OFD+PRF+bg group (group II) equally. The clinical evaluation was measured at the baseline, day-30, and day-90. Results showed that PD (p= 0.022) and RAL (p= 0.008) significantly increased in group I (PD 2.80 ± 0.42; RAL 2.50 ± 0.52) compared to group II (PD 2.10 ± 0.73; RAL 2.00 ± 0.67); however, there was no significant difference in the bone height (p= 0.194). Taken together, our data revealed that I-PRF+bg induces soft tissue regeneration in infrabony pocket treatment.

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Comparative evaluation of bioactive glass bone graft material with platelet rich fibrin and bioactive glass bone graft material alone for the treatment of periodontal intrabony defects: a clinical and radiographic study

Cited by 4 publications

References 9 publications

Clinical and radiographic evaluation and comparison of bioactive bone alloplast morsels when used alone and in combination with platelet‐rich fibrin in the treatment of periodontal intrabony defects—A randomized controlled trial

Clinical and radiographic evaluation and comparison of bioactive bone alloplast morsels when used alone and in combination with platelet‐rich fibrin in the treatment of periodontal intrabony defects—A randomized controlled trial

The Efficacy of Combining Advanced Platelet-Rich Fibrin to Biphasic Alloplast in Management of Intrabony Defects (Randomized Controlled Clinical Trial)

The Effectiveness of injectable platelet-rich fibrin and bone graft addition to open flap debridement for infrabony pocket therapy

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