Comparative evaluation of clinical efficacy of β-tri calcium phosphate (Septodont-RTR) ^TM alone and in combination with platelet rich plasma for treatment of intrabony defects in chronic periodontitis

Abstract

Aim:To assess the clinical outcome by comparing β-tri calcium phosphate (Septodont RTR)™ along with platelet rich plasma (PRP) and β-tri calcium phosphate (β-TCP) alone in intrabony defects, by clinical evaluation in a 6-month analysis.Methodology:Ten patients participated in the study. Using a split-mouth design, interproximal bony defects were surgically treated with either platelet rich plasma (PRP) combined with β-tri calcium phosphate (β-TCP) or β-TCP alone. Plaque Index (PI), Gingival Index, Probing Pocket Depth (PPD), Clinical Attachment Level (CAL) were recorded 6 months after surgery.Results:At 6 months after therapy, the PRP combined with β-TCP group showed mean PPD reduction of 2.50, CAL mean gain of 2.60 + 1.43. The β-TCP group showed mean PPD reduction of 2.80 mm, mean CAL gain of 2.60 mm. On intra-group comparison, there was greater PPD reduction and CAL gain at 6 months in both the groups. In intergroup comparison of PRP/β-TCP and β-TCP alone, there was no statistical significant difference observed. (P = 0.55, and 0.87 for PPD and CAL gain).Conclusion:Both therapies resulted in significant PPD reduction, CAL gain. The present study shows that treatment of intrabony periodontal defects with combination of PRP and β-TCP does not have additional improvements when compared with β-TCP alone within 6 months follow-up.

Socket preservation by beta-tri-calcium phosphate with collagen compared to platelet-rich fibrin: A clinico-radiographic study

“…Overall good oral hygiene during the study may have resulted because of periodic recall visits in which the patients were regularly reinforced for oral hygiene maintenance and underwent supragingival scaling if required. [21] All the clinical parameters were recorded from an FRP on the acrylic stent fabricated on the cast as advocated by Talwar et al [22] Similar to their study, [22] in our study acrylic stent was not used for measuring the buccolingual width. Instead, a bone mapping caliper was used for socket width measurements clinically.…”

“…Overall good oral hygiene during the study may have resulted because of periodic recall visits in which the patients were regularly reinforced for oral hygiene maintenance and underwent supragingival scaling if required. [ 21 ]…”

Evaluation of platelet-rich fibrin and tricalcium phosphate bone graft in bone fill of intrabony defects using cone-beam computed tomography: A randomized clinical trial

“…It might be hypothesized that β-TCP may resorb, thus allowing the newly forming periodontal tissues to fill the available space. [ 12 ]…”

Histological Bone-Healing Evaluation of Critical-Size Defects Filled with β-Tricalcium Phosphate in Rat Tibiae

“…RTR ® (Septodont, Saint-Maur-des-Fosses, France) is a bone substitute comprising β-TCP granules of different sizes, ranging from 500 µm to 1 mm, that is used for bonedefect reconstruction in surgical procedures in dentistry [17], with satisfactory clinical and radiographic results for bone neoformation [17][18][19][20]. RTR ® has been shown to positively influence the differentiation of osteoblasts, the expression of bone morphogenetic proteins (BMPs), and the subsequent expression of markers critical for bone formation, such as alkaline phosphatase, type I collagen, osteopontin, and osteocalcin [18,19].…”