Comparative evaluation of demineralized freeze-dried bone allograft with and without concentrated growth factor membrane in the treatment of periodontal intrabony defects: a randomized controlled clinical trial

Samarth, Gopal K.; Kolte, Abhay; Kolte, Rajashri A; Bajaj, Vinisha Ashok

doi:10.1007/s00784-022-04791-5

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…2 . According to the Cochrane Collaboration’s tool for assessing the risk of bias, eight RCTs [ 40 – 47 ] were classified as having a low risk of bias, while five trials [ 48 – 52 ] presented a high risk of bias, and the other 18 trials [ 29 , 53 – 69 ] demonstrated a moderate risk of bias (Fig. 2 A).…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

Chen,

Cheng,

Cai

et al. 2023

BMC Oral Health

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Background Concentrated growth factor (CGF), a new autologous platelet concentrate, has been widely investigated to the adjunctive treatment of oral diseases. This study aims to evaluate the efficacy of CGF in the surgical treatment of oral diseases. Methods MEDLINE, Web of Science, Scopus, Cochrane, and EMBASE databases were searched up to July 2023. Only randomized clinical trials were included. The methodologic quality was evaluated by the Cochrane Risk of Bias Tool. RevMan 5.4 software was used for data analysis. Results In the treatment of periodontal intrabony defects, bone graft combined with CGF was significantly superior to bone graft (P < 0.01), with mean intrabony defect depth reduction of 1.41 mm and mean clinical attachment level gain of 0.55 mm. In the regenerative surgery of furcation defects, the effect of CGF group was significantly better than control group (P < 0.0001), with mean probing depth reduction of 0.99 mm, vertical bone gain of 0.25 mm, and horizontal bone gain of 0.34 mm. CGF combined with coronally advanced flap (CAF) was more effective than CAF alone (mean keratinized tissue width increase of 0.41 mm, mean gingival thickness increase of 0.26 mm, P < 0.00001), but less effective than connective tissue graft (CTG) combined with CAF (mean root coverage difference of -15.1%, mean gingival thickness difference of -0.5 mm, P < 0.0001). In the alveolar ridge preservation, additional use of CGF reduced horizontal bone resorption by 1.41 mm and buccal vertical bone resorption by 1.01 mm compared to control group (P < 0.0001). The VAS score of CGF group was significantly lower than that of the control group at the 1st and 7th day after oral surgery (P < 0.0001). Conclusions CGF can exert a positive adjunctive effect for the regenerative surgery of periodontal intrabony defects, furcation defects, and alveolar ridge preservation procedure. CGF combined with CAF has a better therapeutic effect on gingival recession compared to CAF alone, although it is not as effective as CTG combined with CAF. CGF could promote postoperative healing and pain relief in oral surgery within a week. There is currently not enough evidence to support the clinical benefits of CGF in other oral surgeries.

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Section: Resultsmentioning

confidence: 99%

“…Three studies [ 64 , 66 , 69 ] with a 12-month follow-up period reported the treatment of periodontal intrabony defects (Table 1 ). All three trials had a moderate risk of bias (Fig.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

Chen,

Cheng,

Cai

et al. 2023

BMC Oral Health

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“…When mixed with autogenous bone, they can reliably achieve vertical ridge augmentation to obtain a high percentage of vital mineralized tissue [ 44 ]. In combination with concentrated growth factor membranes, DFDBA can increase the height, depth and mesiodistal width of periodontal intrabony defects [ 45 ]. The combination of P-PRF and DFDBA, grafted between the implant body and socket wall in immediate implant placement, significantly reduces bone resorption and maintains the buccolingual dimension of the bone [ 46 ].…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Surface demineralized freeze-dried bone allograft followed by reimplantation in a failed mandibular dental implant

Zhang,

Wang,

You

et al. 2023

Regenerative Biomaterials

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The removal of a failed implant with high torque causes significant damage to the surrounding tissue, compromising bone regeneration and subsequent osseointegration in the defect area. Here, we report a case of carrier screw fracture followed by immediate implant removal, bone grafting, and delayed reimplantation. A dental implant with a fractured central carrier screw was removed using the bur-forceps technique. The resulting three-wall bone defect was filled with granular surface demineralized freeze-dried bone allograft (SD-FDBA). Cone-beam computerized tomography was performed at 1 week, 6 months, and 15 months postoperatively, and standardized for quantitative evaluation. The alveolar bone width and height at 15 months post-surgery were about 91% of the original values, with a slightly lower bone density, calculated using the gray value ratio. The graft site was reopened and was found to be completely healed with dense and vascularized bone along with some residual bone graft. Reimplantation followed by restoration was performed 8 months later. The quality of regenerated bone following SD-FDBA grafting was adequate for osseointegration and long-term implant success. The excellent osteogenic properties of SD-FDBA are attributed to its human origin, cortical bone like structure, partly demineralized surfaces, and bone morphogenetic protein-2 containing nature. Further investigation with more cases and longer follow-up was required to confirm the final clinical effect.

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Clinicoradiographic comparative evaluation of 1% melatonin gel plus platelet‐rich fibrin over platelet‐rich fibrin alone in treatment of Grade II furcation defects: A randomized controlled double‐blind clinical trial

Dhande,

Rathod,

Kolte

et al. 2023

Journal of Periodontology

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BackgroundThe present study aims to evaluate and compare the effects of 1% melatonin gel plus platelet‐rich fibrin (PRF) and PRF alone in treatment of furcation defects, clinically and radiographically using cone‐beam computed tomography.MethodsThis split‐mouth clinical trial included 23 patients with 46 bilateral Grade II furcation defects in first or second maxillary or mandibular molars. Control group was treated with PRF alone while the test group was treated with 1% melatonin gel and PRF. Clinical attachment level (CAL) and horizontal probing depth (HPD) were primary outcome parameters while secondary outcome parameters were pocket probing depth (PPD) and defect volume (DV) assessed at 3 and 6 months postoperatively.ResultsSignificantly greater mean reduction of PPD, HPD, and CAL gain was observed in test group (2.23 ± 0.41, 2.36 ± 0.68, and 2.97 ± 0.62 mm, respectively) in comparison with control group (2.83 ± 0.78, 2.85 ± 0.67, and 3.21 ± 0.86 mm, respectively) at 6 months. A significant reduction in the mean DV was exhibited radiographically in test group (1.06 ± 0.5 mm3) as compared with control group (3.94 ± 1.32 mm3) at the end of 6 months. Both the groups showed improvements in assessed parameters.ConclusionsIn Grade II furcation defects the combination therapy of 1% melatonin + PRF shows a statistically significant degree of bone fill within the periodontal tissues and also better results in terms of decrease in PPD, HPD, and a greater CAL gain.

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Comparative evaluation of demineralized freeze-dried bone allograft with and without concentrated growth factor membrane in the treatment of periodontal intrabony defects: a randomized controlled clinical trial

Cited by 4 publications

References 31 publications

Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

Surface demineralized freeze-dried bone allograft followed by reimplantation in a failed mandibular dental implant

Clinicoradiographic comparative evaluation of 1% melatonin gel plus platelet‐rich fibrin over platelet‐rich fibrin alone in treatment of Grade II furcation defects: A randomized controlled double‐blind clinical trial

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