“Comparative Evaluation of Dexmedetomidine and Fentanyl to Attenuate Hemodynamic Response to Laryngoscopy and Intubation.”

Abstract

ntroduction- Endotracheal intubation includes laryngoscopy and intubation, which often evokes cardiovascular responses characterized by increase in arterial pressure, changes in heart rate and disturbance in cardiac rhythm, which are transient variable and unpredictable.The present study was conducted and evaluated to compare the efcacy of dexmedetomidine and fentanyl in attenuating sympathoadrenal response which includes heart rate and arterial blood pressure changes during tracheal intubation. 100 adult patients of either sex belonging to ASAMethods- grade I, II, III belonging to age riagroup 18 to 80 years were posted for elective surgery under general anesthesia. . Total 100 adult patients were randomly divided into 2 groups with 50 patients in each group. Group D-Inj Dexmedetomidine 1mcg/kg 10minutes before laryngoscopy. Group F- Inj Fentanyl 2 mcg/kg 10 minutes before laryngoscopy .In predetermined time heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure were observed and compared in both groups. There was rise in heart rate, systolic blood pressure, diastolic blood pressureResults- mean arterial pressure immediately after intubation, 1min.2min, 3min, 5min and 10 min after intubation Dexmedetomidine 1mcg/kgConclusion- iv produces more favourable hemodynamic response while fentanyl 2mcg/kg less effective for attenuating pressor response to laryngoscopy and endotracheal intubation.