Comparative Evaluation of diagnostic performance of Blood culture, Lateral flow immunoassay, Tube Widal and Slide Widal Test in diagnosis of Enteric fever using a Composite Reference Standard

Mehta, Anjali

doi:10.18535/jmscr/v5i9.101

Cited by 2 publications

(2 citation statements)

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“…Enteric fever is globally recognised as one of the serious public health problems being a potentially fatal and multi systemic infectious disease (Mehta et al, 2017). Socio-Demographic factors have been found to influence the prevalence of enteric fevers like typhoid where it mainly affect children and young adults whereas in high-income countries it is primarily a disease of returning travellers (Deksissa and Gebremedhin, 2019).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of typhoid fever among patients attending Murtala Muhammad Specialist Hospital Kano

Mujahid¹,

Yusuf²,

Abbas³

et al. 2022

Bayero J. Pure App. Sci.

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Typhoid fever poses a serious public health problem in Nigeria and is largely diagnosed based on the Widal agglutination test which has been proven to be neither sensitive nor specific. This study determined the prevalence of typhoid fever using both Widal agglutination test and blood culture using automated microbiology systems (BD BACTEC). The study was carried out among 90 patients attending Murtala Muhammad Specialist Hospital in Kano. Out of the 90 cases recruited for the study, none of the cases (0, 0.0%) had S. Typhi isolated using blood culture. However, 18 cases (20%) had other bacteria which are not S. Typhi isolated using blood culture while 72 cases (80%) were negative. For the Widal test, 63 cases (70%) were positive for anti S. Typhi O antigen while 27 cases (30%) were negative. Similarly, 42 cases (46.7%) were positive for anti S. Typhi H antigen, while 48 cases (53.3%) were negative. Type of toilet system was found to be significantly associated with non S. Typhi bacteraemia (P=0.021). The studyrecommends the use of other diagnostic test such as molecular techniques to determine the sensitivity and specificity of both Widal and cultural methods.

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Section: Discussionmentioning

confidence: 99%

“…These illnesses are not easily distinguishable especially in the initial stage and hence pose a great challenge in clinical diagnosis. Undiagnosed and untreated cases may result in serious complications such as typhoid perforation (Mehta et al, 2017).…”

Section: Bajopas Volume 15 Number 1 June 2022mentioning

confidence: 99%

Prevalence of typhoid fever among patients attending Murtala Muhammad Specialist Hospital Kano

Mujahid¹,

Yusuf²,

Abbas³

et al. 2022

Bayero J. Pure App. Sci.

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A Comparative Evaluation of Rapid Card and Widal Slide Agglutination Tests for Rapid Diagnosis of Typhoid Fever

Jahan

Khatoon

Mishra

et al. 2021

Medical Journal of Dr. D.Y. Patil Vidyapeeth

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Background: Typhoid fever is a serious public health problem. It causes severe systemic infection in lesser developed areas of the world. Although blood culture is regarded as the gold standard for diagnosis, it is a time taking procedure. An early and accurate diagnosis is necessary for an effective treatment. Aims: The present study was done to comparatively evaluate rapid card and Widal slide agglutination tests for rapid diagnosis of typhoid cases. Settings and Design: The study design was a cross-sectional descriptive study done over a period of 6 months from January to June 2018. Materials and Methods: A total of 265 patients suspected of typhoid fever who gave their consent were included in the study whose blood samples were tested by both rapid card and Widal slide agglutination tests. Statistical Analysis Used: The collected data were analyzed using SPSS Data Editor Software version 20. Percentage of variables was calculated. Results: Of 265 patients, 97 patients were positive by the Widal slide test, whereas 113 patients were positive by the rapid card test, with 96.9% sensitivity and 88.7% specificity. Of 113 positives, 83 cases were positive for immunoglobulin M (IgM) only, whereas 30 cases were positive for both IgM and IgG. Conclusion: Rapid card test is a simple and easy to perform the diagnostic test for rapid detection of typhoid cases with an additional advantage of separate determination of IgM and IgG antibody, thereby aiding in identification of current infection and previous exposure so that appropriate and timely treatment could be given to the patients.

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Comparative Evaluation of diagnostic performance of Blood culture, Lateral flow immunoassay, Tube Widal and Slide Widal Test in diagnosis of Enteric fever using a Composite Reference Standard

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Cited by 2 publications

References 8 publications

Prevalence of typhoid fever among patients attending Murtala Muhammad Specialist Hospital Kano

Prevalence of typhoid fever among patients attending Murtala Muhammad Specialist Hospital Kano

A Comparative Evaluation of Rapid Card and Widal Slide Agglutination Tests for Rapid Diagnosis of Typhoid Fever

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