Comparative evaluation of Elecsys, Atellica, and Alinity assays for measuring the anti-Hepatitis C virus (HCV) antibody

Cho, Youn Keong; Kim, Sinyoung; Kim, Hyun Ok; Choi, Da Som; Kim, Hyun Sook; Park, Younhee

doi:10.1016/j.jcv.2021.104910

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…However, they use different methods and molecular targets for generating and detecting signals and, as a result, may have different levels of diagnostic performance. Some studies reported discrepancies among assays and great variability in cutoff points for predicting TP HCV infection, such as 200 for the Elecsys assay, 19 for the Elecsys II assay, 3-5 for the AR-CHITECT assay, 7-8 for the Vitros assay, 11 for the ADVIA Centaur, and three for the Access assay [27][28][29][30]. Although anti-HCV assays are highly sensitive and specific, their diag- nostic accuracy requires standardization and improvement.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic significance of hepatitis C virus antibody levels for chronic hepatitis C virus infection

Kang

Jang

Kim

et al. 2023

Korean J Intern Med

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Background/Aims: Although anti-hepatitis C virus (HCV) assay is widely used to screen for HCV infection, it has a high false-positive (FP) rate in low-risk populations. We investigated the accuracy of anti-HCV signal-to-cutoff (S/CO) ratio to distinguish true-positive (TP) from FP HCV infection. Methods: We retrospectively analyzed 77,571 patients with anti-HCV results. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic accuracy of anti-HCV S/CO ratio in anti-HCV positive patients.

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Section: Discussionmentioning

confidence: 99%

The diagnostic significance of hepatitis C virus antibody levels for chronic hepatitis C virus infection

Kang

Jang

Kim

et al. 2023

Korean J Intern Med

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Hepatitis C Virus

Slev

2023

ClinMicroNow

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Hepatitis C virus (HCV) is classified within the family Flaviviridae in its own genus Hepacivirus . Phylogenetic analysis of helicase sequences has been used to probe its relatedness to other viruses in the family. Serum and plasma are acceptable for HCV nucleic acid amplification tests (NAATs) and serology tests. HCV core antigen detection/quantification tests have been developed as alternatives to HCV RNA assays. HCV genotypes and subtypes can be determined by commercial and laboratory‐developed NAATs based on a variety of biochemical methods. With the emergence of the simplified pangenotypic treatment algorithms for the treatment naive, the clinical utility of baseline testing for the presence of resistance‐associated substitutions (RASs) that are associated with direct‐acting antiviral (DAA) therapy failures has been greatly reduced. Sequencing is the diagnostic method of choice for RAS detection. Initiating DAA therapy is recommended for both acute and pediatric HCV infections.

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Comparative evaluation of four commercial analyzers for the serological screening of hepatitis A, B, C and HIV

Kutvonen

Jarva

Lappalainen

et al. 2022

Journal of Clinical Virology

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Comparative evaluation of Elecsys, Atellica, and Alinity assays for measuring the anti-Hepatitis C virus (HCV) antibody

Cited by 3 publications

References 15 publications

The diagnostic significance of hepatitis C virus antibody levels for chronic hepatitis C virus infection

The diagnostic significance of hepatitis C virus antibody levels for chronic hepatitis C virus infection

Hepatitis C Virus

Comparative evaluation of four commercial analyzers for the serological screening of hepatitis A, B, C and HIV

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