A 4.5-year-old female child presented to the Department of Pediatric Dentistry with the chief complaints of sharp, localized pain in her lower left and right back teeth persisting for a week, indicative of irreversible pulpitis in teeth 74, 75, and 85. A single-visit pulpectomy was planned for all affected teeth, followed by full coronal restoration in two separate visits. Before the procedure, informed digital consent was taken from the parents. A topical anesthetic agent and inferior alveolar nerve block were administered for effective anesthesia. Rubber dam isolation was performed to ensure aseptic conditions, and access cavity preparation was carried out using appropriate burs. Biomechanical preparation (BMP) was performed using Kedo S Square (Kedo Dental, Chennai, India) in tooth 74, Kedo S Plus (Kedo Dental) in tooth 75, and Kedo Nano Plus (Kedo Dental) in tooth 85, with specific instrumentation techniques as per literature guidelines. The root canals were thoroughly cleaned and shaped to facilitate optimal disinfection and obturation. This case demonstrates the successful management of irreversible pulpitis in the lower primary molar using single-visit pulpectomy with Kedo single filing systems, highlighting the importance of effective BMP in pediatric endodontics.