Comparative evaluation of fatty infiltration of the liver in dairy cattle by using blood and serum analysis, ultrasonography, and digital analysis

Acorda, Jezie A.; Yamada, Hiroyuki; Ghamsari, Seyed Mehdi

doi:10.1080/01652176.1995.9694522

Cited by 17 publications

(18 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is interesting that our findings are similar to those recorded in cattle for the diagnosis of diffuse liver diseases [23]. Digital analysis showed higher sensitivity and specificity for the diagnosis of lipidosis in cattle than ultrasonography [28]. Based on the histopathological classification [9], all severely affected animals had increased diffuse echogenicity of the liver, which indicated an advanced state.…”

Section: Discussionsupporting

confidence: 87%

Ultrasonographic evaluation to diagnose hepatic lipidosis in Egyptian Zaraibi goats with vitamin B12 deficiency

El-Khodery

Hussein

El‐Boshy

et al. 2011

Journal of Advanced Research

View full text Add to dashboard Cite

As little is known about the ultrasonographic features of hepatic lipidosis (white liver disease) in goats, this study was undertaken to evaluate the use of ultrasound for the diagnosis of hepatic lipidosis associated with vitamin B12 (cyanocobalamin) deficiency in Egyptian Zaraibi goats. A total of 38 goats (28 with weight loss, diarrhoea and anaemia and 10 clinically healthy) were studied. Twenty-one goats were demonstrated to have cobalt and cyanocobalamin deficiency (0.33 ± 0.12 lmol/l and 0.17 ± 0.10 lg/l, respectively). Goats were examined with a real-time ultrasound system using a 5-MHz convex transducer. Ultrasound-guided liver biopsies and blood samples were obtained from each animal at examination. Based on the histopathological findings, diseased goats were classified as having mild (n = 6), moderate (n = 6) or severe lipidosis (n = 9). Ultrasonographic-hepatic changes were recorded in 19 (90.4%) out of 21 goats. Severe lipidosis showed diffuse hyper-echogenicity of hepatic parenchyma. However, focal hyper-echoic lesions with various shapes, sizes and positions were visualized in mild and moderate lipidosis. Liver size increased significantly (P < 0.05) in severely affected goats compared with the controls. Histopathologically, macrovacuolations, congestion of hepatic sinusoids and infiltration of the portal area with inflammatory cells and connective tissues were evident in moderate and severely affected cases. Journal of Advanced ResearchThere were varying degrees of anaemia, hypoglycemia and hypoproteinemia with significant increases (P < 0.05) of aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in diseased animals compared with the controls. In conclusion, ultrasound may be a useful diagnostic tool in goats with suspected hepatic lipidosis associated with vitamin B12 deficiency.

show abstract

Section: Discussionsupporting

confidence: 87%

Ultrasonographic evaluation to diagnose hepatic lipidosis in Egyptian Zaraibi goats with vitamin B12 deficiency

El-Khodery

Hussein

El‐Boshy

et al. 2011

Journal of Advanced Research

View full text Add to dashboard Cite

show abstract

“…7 Mild and moderate fatty liver can result in changes in liver function that are not accompanied by hepatocyte destruction and increases in liver-specific enzyme activities. 6,[24][25][26][27][28][29][30][31][32][33] There are significant alterations in the results of specific tests for liver function, particularly in dairy cows with severe fatty liver; however, it is emphasized that they should be interpreted with caution because of considerable individual variation. The present study is consistent with previous work.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Sodium Borate in the Prevention of Fatty Liver in Dairy Cows

Basoglu¹,

Sevinc²,

Birdane³

et al. 2002

J Vet Int Med

View full text Add to dashboard Cite

The effects of sodium borate (100 mg/kg body weight, PO, 15 days) from a month before expected calving until a month after calving were evaluated in dairy cows susceptible to fatty liver. Cows received either sodium borate (n ϭ 13) or no treatment (n ϭ 10). All cows had mild fatty livers and increased plasma triglycerides and very low density lipoprotein (VLDL) concentrations at the beginning of the experiment. The control group of cows developed significant fatty liver after calving, and 2 of them had severe fatty liver associated with clinical and biochemical abnormalities. There were no clinicopathological signs related to sodium borate administration. Serum triglycerides and VLDL concentrations before calving decreased significantly at calving and after calving in controls, and they were within the normal range only after calving. There were significant alterations during the experiment in some hematological and chemical variables between groups, within period, but they were within the normal range. Unlike treated cows, serum triglycerides and VLDL concentrations correlated with liver fat content after calving in untreated cows. Our results document that sodium borate decreases the degree of fatty liver in dairy cows during early lactation.

show abstract

“…These features are due to the lower acoustic impedance of fat than the normal liver parenchyma, which results in higher echogenicity of fat infiltrated livers and advanced attenuation of ultrasound waves in depth of the tissue (Acorda et al 1994). Liver quantitative ultrasonography followed by digital analysis of sonographs has gained a potential as a non-invasive method in detection of fatty liver and estimating liver triglyceride content in confirmed cases of fatty liver in dairy cattle (Acorda et al 1994(Acorda et al , 1995Bobe et al 2008;Thijssen et al 2008;Starke et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Periparturition alterations to liver ultrasonographic echo-texture and fat mobilization parameters in clinically healthy Holstein cows

et al. 2011

View full text Add to dashboard Cite

The objective of present study was to record the sequential alterations in liver echo-texture through digital analyzing of the B-mode ultrasonography in three groups of under-conditioned (UC), moderate-conditioned (MC), and over-conditioned (OC) clinically healthy Holstein cows from 30 days to calving until 30 days in milk. Furthermore, to compare their changes in association with the changes of fat mobilization parameters of non-esterified fatty acids (NEFA), betahydroxybutyric acid (BHBA), and body condition score (BCS). Although the cows lost significant (P < 0.05) BCS from calving and the NEFA values showed an increasing trend near calving and the BHBA values significantly inclined postparturition, the mean grey scale histogram (MGSH) of liver images did not reveal significant fluctuations unless a significant decrease on calving day (P < 0.05). The MGSH drop was predicted to be the result of anatomical changes in abdominal cavity, related to delivery and liver's blood flow. OC cows had higher NEFA on day +20 than UC and MC cows (P < 0.05). UC cows showed higher MGSH values on day -30 than MC cows and again on day -10 comparing to MC and OC cows (P < 0.05). MGSH values correlated with BCS values (rUC = -0.186; rMC = -0.283; rOC = -0.158). It was concluded that the studied cows did not show significant alterations in textural changes in their liver ultrasound whilst going through fat mobilization. As quantitative ultrasonography has shown the potential to detect cases of fatty liver, it could gain the attention to become a feasible device for liver health monitoring on a herd basis.

show abstract

Comparative evaluation of fatty infiltration of the liver in dairy cattle by using blood and serum analysis, ultrasonography, and digital analysis

Cited by 17 publications

References 7 publications

Ultrasonographic evaluation to diagnose hepatic lipidosis in Egyptian Zaraibi goats with vitamin B12 deficiency

Ultrasonographic evaluation to diagnose hepatic lipidosis in Egyptian Zaraibi goats with vitamin B12 deficiency

Efficacy of Sodium Borate in the Prevention of Fatty Liver in Dairy Cows

Periparturition alterations to liver ultrasonographic echo-texture and fat mobilization parameters in clinically healthy Holstein cows

Contact Info

Product

Resources

About