Comparative evaluation of herbal coccidiostat with chemotherapeutic coccidiostats on performance of broilers to control coccidiosis

Srinivasu, B; Preetam, V. Chinni; Gurram, Srinivas; Reddy, A Rajashekher

doi:10.1007/s11250-020-02220-x

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…The Echinacea purpurea ’s anti‐coccidial effect has been referred to as its immunomodulating properties, broadly reported (Arczewska‐Włosek et al., 2018 ; Fabia et al., 2021 ). E. purpurea extract triggers the innate immune response by activating macrophages (Goel et al., 2002 ), macrophage‐derived cytokine creation and activation of natural killer cells and polymorphonuclear leukocytes, therefore, acting as an immunostimulant (Currier & Miller, 2001 ; Srinivasu et al., 2020 ). Glycyrrhiza glabra extract has bioactive components, such as glycyrrhizin and flavonoids, which have medicinal and pharmacological activities (Pop et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of therapeutic effects of an herbal mixture (Echinacea purpurea and Glycyrrhiza glabra) for treatment of clinical coccidiosis in broilers

Ghafouri

Ghaniei

Tamannaei

et al. 2022

Veterinary Medicine & Sci

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Background Avian coccidiosis is thought to be one of the most expensive infectious diseases in the poultry industry. Objectives Safe and alternative anti‐coccidial drugs are herbal extracts because they do not result in tissue residue and drug resistance. The objective of the present study was to evaluate the anti‐coccidial effect of the herbal mixture, a complex of two plants (Echinacea purpurea, Glycyrrhiza glabra) in broiler chickens in comparison with toltrazuril. Methods One hundred twenty broiler chickens were used in this experiment and divided into 4 equally numbered groups. All the groups, except Group D, were experimentally infected with mixed Eimeria spp. (E. Tenella, E. maxima, E. necatrix and E. brunetti) on day 14. Group A treated with an herbal mixture [Glycyrrhiza glabra Extract 5% (standardised to 5.4% glycyrrhizic acid) and Echinacea purpurea Extract 2% (standardised to 4% total phenolic content based on chlorogenic acid); Coxinin‐EC®; Shamim Teb Sepid Giti]. Group B treated with toltrazuril. Group C was experimentally infected with mixed Eimeria spp. but they did not have any treatment, this group was our positive control. Performance indices, faecal oocyst excretion, and intestinal lesion score were determined during the experiment. Results Positive control group had the poorest results and more mortality than other groups. Group D was not infected and was healthy all the experiment period. Treatment with herbal complex significantly reduced the negative performance and pathogenic effects associated with Eimeria spp. at a level that was comparable with toltrazuril. Conclusions In summary, the anti‐coccidial activity of the studied herbal complex suggests its use as an alternative anti‐coccidial agent to chemotherapeutic drugs for controlling coccidiosis in poultry. Highlights ‐Coccidiosis is an important infectious disease that causes serious financial loss to the poultry industry. ‐Chemical anti‐coccidial drugs and vaccines are the main control strategies to combat the disease. However, these tools have some constraints. ‐Herbal remedies are suitable alternatives to chemical compounds for control of losses associated with coccidiosis in poultry. ‐An herbal mixture (Echinacea purpurea, Glycyrrhiza glabra) has promising effects for controlling of coccidiosis in broiler chickens.

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Section: Discussionmentioning

confidence: 99%

Evaluation of therapeutic effects of an herbal mixture (Echinacea purpurea and Glycyrrhiza glabra) for treatment of clinical coccidiosis in broilers

Ghafouri

Ghaniei

Tamannaei

et al. 2022

Veterinary Medicine & Sci

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“…Based on references and proper modification ( 24 , 25 ), broilers were infested by oral challenging with coccidial sporulated oocysts propagated from field isolates (30,000/in 1 mL/bird). After 4 days, broilers oral gauge with 1 mL of culture containing 10 9 CFU/mL of C. perfringens ATCC13124 for 3 days.…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics and pharmacodynamics of isopropoxy benzene guanidine against Clostridium perfringens in an intestinal infection model

Yang²,

Zhang³

et al. 2022

Front. Vet. Sci.

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This study aimed to evaluate the antibacterial activity of isopropoxy benzene guanidine (IBG) against C. perfringens based on pharmacokinetics/pharmacodynamics (PK/PD) modeling in broilers. The PK parameters of IBG in the plasma and ileal content of C. perfringens-infected broilers following oral administration at 2, 30, and 60 mg/kg body weight were investigated. in vivo PD studies were conducted over oral administration ranging from 2 to 60 mg/kg and repeated every 12 h for 3 days. The inhibitory Imax model was used for PK/PD modeling. Results showed that the MIC of IBG against C. perfringens was 0.5–32 mg/L. After oral administration of IBG, the peak concentration (Cmax), maximum concentration time (Tmax), and area under the concentration-time curve (AUC) in ileal content of broilers were 10.97–1,036.64 mg/L, 2.39–4.27 h, and 38.31–4,266.77 mg·h/L, respectively. After integrating the PK and PD data, the AUC0 − 24h/MIC ratios needed for the bacteriostasis, bactericidal activity, and bacterial eradication were 4.00, 240.74, and 476.98 h, respectively. For dosage calculation, a dosage regimen of 12.98 mg/kg repeated every 12 h for 3 days was be therapeutically effective in broilers against C. perfringens with MIC ≤ 2 mg/L. In addition, IBG showed potent activity against C. perfringens, which may be responsible for cell membrane destruction. These results can facilitate the evaluation of the use of IBG in the treatment of intestinal diseases in broilers caused by C. perfringens.

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“…Cocciban, an herbal product, (1000 g/ton) effectively controlled a mixed infection with Eimeria spp. resulted in higher feed efficiency, body weight gain, and mean percent livability (78.33%) in the treated groups than the other infected groups, however lower than that of the healthy control group (Srinivasu et al 2020). The organic feed additive Calica+ improves growth performance and shows anticoccidial effects in broilers (Martel-Kennes et al 2019).…”

Section: 3mentioning

confidence: 96%

Avian Coccidiosis: Recent Advances in Alternative Control Strategies and Vaccine Development

Khater¹

2020

Agrobiol. Records

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Coccidiosis induces huge economic losses to poultry production. Its control through anticoccidial live vaccines and drugs has been very successful with some limitations because of the cost of production of live vaccines, drug resistance, and residues representing public health concerns. Consequently, there is a crucial need for drug-free production of foods. Useful strategies include environmental, immunological, and genetic approaches; feed additives are recent attitudes involving probiotics, synbiotics, organic acids, phytobiotics as essential oils, antioxidants, and nanobiotics (nanoparticles). A combination of such additives is a recent useful trend. Transgenic Eimeria parasite could fill in the gap in the control of chicken coccidiosis as an efficient anticoccidial vaccine with improved protective efficacy using multiple vaccine antigens. Alternatives justify further studies as therapeutic or prophylactic anticoccidial agents. Full biological and toxicology profiles are crucial for the promising materials which deserve to be applied on a larger scale.

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Comparative evaluation of herbal coccidiostat with chemotherapeutic coccidiostats on performance of broilers to control coccidiosis

Cited by 6 publications

References 5 publications

Evaluation of therapeutic effects of an herbal mixture (Echinacea purpurea and Glycyrrhiza glabra) for treatment of clinical coccidiosis in broilers

Evaluation of therapeutic effects of an herbal mixture (Echinacea purpurea and Glycyrrhiza glabra) for treatment of clinical coccidiosis in broilers

Pharmacokinetics and pharmacodynamics of isopropoxy benzene guanidine against Clostridium perfringens in an intestinal infection model

Avian Coccidiosis: Recent Advances in Alternative Control Strategies and Vaccine Development

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