Comparative evaluation of incorporation calcium silicate and calcium phosphate nanoparticles on biomimetic dentin remineralization and bioactivity in an etch-and-rinse adhesive system

Abstract

Background This study aimed to evaluate the remineralization potential and bioactivity of adhesives, containing amorphous calcium phosphate (ACP) and calcium silicate (CS) nanoparticles (NPs). Material and Methods In this study, dentin slices (n=60) were prepared and etched with phosphoric acid. Next, they were divided into two groups: pre- and post-immersion in a simulated body fluid (SBF) for three weeks. The two groups were also divided into five subgroups (n=6 per subgroup), including the control (0 wt.% NPs); adhesives containing 1 wt.% and 2.5 wt.% (CS) nanoparticles; and adhesives containing 1 wt.% and 2.5 wt.% ACP nanoparticles. The remineralization potential and bioactivity of the adhesives were evaluated. The shear bond strength of the samples (n=18) was also assessed using a universal testing machine. Results The present results revealed that the adhesive containing ACP and CS nanoparticles showed bioactivity and remineralization potential without any reduction in the bond strength. Conclusions The outcomes revealed that Cs and ACP nanoparticles induced mineralization in the dentin and incorporation of these nanoparticles to dentin bonding agents could improve the bio-functionalization of dentin bond. Key words: Calcium phosphate, calcium silicate, fourier transform infrared spectroscopy, scanning electron microscopy, tooth remineralization.

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“…Further research on biomimetic dental adhesives and dental restorative materials containing bioactive particles should be conducted as they may exhibit remineralizing potential to enamel and/or dentin-resin interface [72][73][74][75].…”

Synergistic effect of ion-releasing fillers on the remineralization and mechanical properties of resin–dentin bonding interfaces

“…Yang et al [122] showed that adding more hydrated calcium silicate (HCS) fillers to the resin resulted in higher calcium and silica ion release and favored increased flexural strength. Ashtijoo et al [123] showed that adding up to 2.5 wt% of calcium silicate nanoparticles increased remineralization potential and bioactivity without negatively affecting bond strength. Adding ion-releasing fillers resulted in a change in the refractive index.…”