Comparative evaluation of interpolyelectrolyte complexes of chitosan with Eudragit® L100 and Eudragit® L100-55 as potential carriers for oral controlled drug delivery

Moustafine, Rouslan I.; Margulis, Evgeniya B.; Sibgatullina, Liliya F.; Кеменова, В. А.; Mooter, Guy Van den

doi:10.1016/j.ejpb.2008.04.008

Cited by 83 publications

(45 citation statements)

References 34 publications

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“…However, only limited research has been directed toward detailed investigations of structural and compositional microenvironment transformations during swelling and release evaluation. 40,41 The objective of this study was to investigate some fundamental physicochemical characteristics of new IPECs made up of EPO and L100-55 in aqueous solutions in order to monitor possible structural transformation and composition changes of polycomplexes matrices during swelling and release in simulated gastrointestinal (GI) conditions with respect to their potential application in oral drug delivery. Diclofenac sodium (DS) was used as a model drug.…”

Section: Introductionmentioning

confidence: 99%

Structural Transformations During Swelling of Polycomplex Matrices Based on Countercharged (meth)acrylate Copolymers (EudragitR EPO/EudragitR L 100-55)

Moustafine

Bobyleva

Bukhovets

et al. 2011

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Structural Transformations During Swelling of Polycomplex Matrices Based on Countercharged (meth)acrylate Copolymers (EudragitR EPO/EudragitR L 100-55)

Moustafine

Bobyleva

Bukhovets

et al. 2011

Journal of Pharmaceutical Sciences

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“…Swelling depends on the polymer concentration and the moisture absorption capacity of the polymers (45). Flexibility of polymer chain from individual polymer is important for interpenetration and entanglement, and in presence of water molecules, polymers become crosslinked and the mobility of individual polymer chain decreases and swelling occurs (46).…”

Section: Discussionmentioning

confidence: 99%

Dental Mold: A Novel Formulation to Treat Common Dental Disorders

2009

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Abstract. Oral administration of antibiotics to treat dental problems mostly yields slow actions due to slow onset and hepatic "first-pass." Again, commonly used dental paints are generally washed out by saliva within few hours of application. To overcome the challenges, polymeric molds to be placed on an affected tooth (during carries and gum problems) were prepared and evaluated in vitro for sustained drug release for prolonged local action. Here, amoxicillin trihydrate and lidocaine hydrochloride were used as model drugs. Dental molds were prepared using corn zein, carbopol 934 P, gum karaya powder, and poloxamer 407 by mixing and solvent evaporation technique. Different physicochemical evaluation studies such as tooth adhesion test, surface pH, swelling index, and drug-distribution pattern were carried out. Percentage swelling varied from 56% to 93%. Average tooth adhesion strength and mean initial surface pH of the formulations were 50 g and 6.5, respectively. As assessed by scanning electron microscopy, drug distribution was uniform throughout the matrix. Cumulative percentage release of lidocaine hydrochloride and amoxicillin trihydrate in simulated saliva were 98% and 50%, respectively. In vitro drug-release studies revealed the sustained-release patterns of the drugs in simulated saliva at least for 24 h. The stability study shows that the drugs were stable in the formulations following the conditions as per ICH guideline. The formulation is a novel approach to deliver the drug(s) for a prolonged period for local action upon its application on an affected tooth.

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“…The literature was focused essentially on tablet formulations based on IPEC between sodium alginate (anionic) and the cationic Eudragit EPO 22,25,26 or Eudragit RL 27 ; and between chitosan (cationic) with different types of anionic Eudragits. 28,29 Production of large sized beads of chitosan/succinic acid/Eudragit RS/RL was also carried out. 30 However, the use of different carriers, such as microparticles, based on IPEC between natural polymers and Eudragits, was not too much investigated.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic atomization and polyelectrolyte complexation to produce gastroresistant shell–core microparticles

Dalmoro

Sitenkov

Lamberti

et al. 2015

J of Applied Polymer Sci

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In this study ultrasound-assisted atomization technique was combined with two-stages polyelectrolyte complexation to produce enteric shell-core microparticles encapsulating a non-steroidal, anti-inflammatory gastrolesive active ingredient indomethacin. In particular, a solution of the anionic biopolymer alginate, containing indomethacin, was sprayed in fine droplets which were complexed with a cationic (meth)acrylate copolymer, Eudragit V R E 100, which, in turn, was complexed by the anionic copolymer Eudragit V R L30D-55. The first complexation stage was applied to achieve a high drug encapsulation efficiency; the second one to assure good gastroresistance feature. The novel protocol has been found more effective in terms of loading, encapsulation efficiency, and enteric properties during in vitro release tests, than conventional procedures which involved alginate cross-linking by charged ions. Furthermore ultrasonic atomization-polyelectrolytes complexation preparation approach was performed using mild conditions, aqueous solutions, in the absence of organic solvents and chemical cross-linkers.

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Comparative evaluation of interpolyelectrolyte complexes of chitosan with Eudragit® L100 and Eudragit® L100-55 as potential carriers for oral controlled drug delivery

Cited by 83 publications

References 34 publications

Structural Transformations During Swelling of Polycomplex Matrices Based on Countercharged (meth)acrylate Copolymers (EudragitR EPO/EudragitR L 100-55)

Structural Transformations During Swelling of Polycomplex Matrices Based on Countercharged (meth)acrylate Copolymers (EudragitR EPO/EudragitR L 100-55)

Dental Mold: A Novel Formulation to Treat Common Dental Disorders

Ultrasonic atomization and polyelectrolyte complexation to produce gastroresistant shell–core microparticles

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