Comparative Evaluation of Opioid-Induced Changes in Immune Reactivity of CBA Mice

Cheido, M. A.; Gevorgyan, M. M.; Жукова, Е. Н.

doi:10.1007/s10517-014-2349-8

Cited by 9 publications

(4 citation statements)

References 10 publications

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“…The effect of dopamine antagonists on IgM immune response was recently established by Cheido et al . ; they found that in mice, blockade of the D2 receptor significantly elevated the IgM humoral response. The formation of immune complex is the principal way of activating the classical pathway of the complement system .…”

Section: Drugs Affecting the Inflammatory Responsementioning

confidence: 97%

Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum

Patel

Ortega‐Loayza

2017

Br J Dermatol

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This study aimed to explore how drug-induced pyoderma gangrenosum develops in the body. Pyoderma gangreno-sum (PG) is a rare autoinflammatory disease (a genetic disease caused by a malfunctioning immune system) that causes tissue cells to die, resulting in severe and painful ulcers. Drug-induced disease is where a disease occurs, or is triggered, as a result of taking medication/drugs. In this study 43 cases of patients diagnosed with drug-induced PG were reviewed. The authors found that most of the medications associated with drug-induced PG affected more the one element in the pathway that leads to a person developing drug-induced PG. Abnormal neutrophil migration and function, dysregulated inflammation, keratinocyte apoptosis, and alteration of epigenetic mechanisms were all found to be associated with the development of drug-induced PG. Abnormal neutrophil migration and function refers to the irregular movement and function of a specific type of white blood cell (which forms part of the body's immune system). Dysregulated inflammation refers to an abnormal inflammation response in the body's cells and tissue. Ker-atinocyte apoptosis means the death of keratinocyte cells (the cells that form the majority of the outer layer of skin). Alteration of epigenetic mechanisms means a change to the way in which a cell reads and understands its own genes, which in turn affects how the cell behaves. The authors conclude that, in order to better understand how PG develops, further research is needed into the immune system, epigenetics (the way in which a cell reads and acts upon its genes) and NETosis (a form of cell death).

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Section: Drugs Affecting the Inflammatory Responsementioning

confidence: 97%

Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum

Patel

Ortega‐Loayza

2017

Br J Dermatol

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“…In some studies, DOR activation has also been shown to suppress immune function, while KOR activation has a mixed effect on immune function. [146][147][148] In summary, these cumulative research findings stipulate that opioids can have both stimulatory and inhibitory effects on the maturation, differentiation, and migration of immune cells in the tumor microenvironment, along with their analgesic properties (Table 2). However, the differences in the research outcomes may be correlated to the different model systems used, variability in the experimental testing conditions, drug dosages, and treatment times.…”

Section: Immune System Modulationmentioning

confidence: 99%

“…In some studies, DOR activation has also been shown to suppress immune function, while KOR activation has a mixed effect on immune function. [ 146–148 ]…”

Section: Introductionmentioning

confidence: 99%

The Role of Opioid Receptors in Cancer

et al. 2023

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Opioids are one of the most potent drugs for treating moderate to severe pain. Despite irrefutable clinical application in chronic pain management, the long-term use of opioids has been increasingly questioned due to undesired side effects that demand attention. Opioids such as morphine mediate clinically relevant effects primarily through the μ-opioid receptor that go beyond their classical role as analgesics, causing potentially fatal side effects such as tolerance, dependence, and addiction. Furthermore, there is growing evidence that opioids affect immune system function, cancer progression, metastasis, and recurrence. Though a biological plausibility, the clinical evidence for the action of opioids on cancer is mixed, revealing a more complex picture as researchers struggle to establish a vital link between opioid receptor agonists, cancer progression, and suppression, or both. Thus, in light of the uncertainty of opioid effects on cancer, in this review, a focused overview of the role of opioid receptors in modulating cancer progression, their underlying signaling mechanisms, and the biological activity of opioid receptor agonists and antagonists is provided.

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“…Although endogenous opioid peptides have a main function as neurotransmitters, they are also known to modulate innate and acquired immune responses [ 79 ]. Opioid receptor signaling can, for example, skew T cell differentiation, increase antibody production in B cells, and affect phagocytosis in macrophages [ 80 , 81 , 82 ]. These effects have also been described in immune cells after hydrolysate administration.…”

Section: Receptor Bindingmentioning

confidence: 99%

Immunomodulatory Protein Hydrolysates and Their Application

2018

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Immunomodulatory protein hydrolysate consumption may delay or prevent western immune-related diseases. In order to purposively develop protein hydrolysates with an optimal and reproducible immunomodulatory effect, knowledge is needed on which components in protein hydrolysates are responsible for the immune effects. Important advances have been made on this aspect. Also, knowledge on mechanisms underlying the immune modulating effects is indispensable. In this review, we discuss the most promising application possibilities for immunomodulatory protein hydrolysates. In order to do so, an overview is provided on reported in vivo immune effects of protein hydrolysates in both local intestinal and systemic organs, and the current insights in the underlying mechanisms of these effects. Furthermore, we discuss current knowledge and physicochemical approaches to identify the immune active protein sequence(s). We conclude that multiple hydrolysate compositions show specific immune effects. This knowledge can improve the efficacy of existing hydrolysate-containing products such as sports nutrition, clinical nutrition, and infant formula. We also provide arguments for why immunomodulatory protein hydrolysates could be applied to manage the immune response in the increasing number of individuals with a higher risk of immune dysfunction due to, for example, increasing age or stress.

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Comparative Evaluation of Opioid-Induced Changes in Immune Reactivity of CBA Mice

Cited by 9 publications

References 10 publications

Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum

Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum

The Role of Opioid Receptors in Cancer

Immunomodulatory Protein Hydrolysates and Their Application

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