Comparative evaluation of phenolic phytochemicals from perilla seeds of diverse species and screening for their tyrosinase inhibitory and antioxidant properties

Kim, D.H.; Lee, J.H.

doi:10.1016/j.sajb.2019.03.015

Cited by 19 publications

(15 citation statements)

References 44 publications

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“…Perilla seed has been reported to contain five flavones, nine phenolic acids, and one tyrosol (Table 6). Among them, apigenin and luteolin in flavones and rosmarinic acid and rosmarinic acid‐3‐ O ‐glucoside in phenolic acids are the most abundant ones (Guan et al., 2014; Kim & Lee, 2019; Lee et al., 2013; Zhou et al., 2014). Besides, flavan‐3‐ols (catechin), flavones (apigenin‐7‐ O ‐glucoside), and phenolic acids (rosmarinic acid methyl ester and ferulic acid) were identified in perilla seed (Guan et al., 2014; Ha et al., 2012; Peng et al., 2005).…”

Section: Polyphenols and Other Bioactives In Specialty Seedsmentioning

confidence: 99%

“…Numerous factors, such as genotype (variety and/or cultivar), seasons, agricultural practices, and environment conditions, among others, have been shown to affect the nutritional and functional characteristics of specialty seeds. This in turn influences the biological activities, especially the antioxidant effect of selected specialty seeds (Irakli et al., 2019; Kim & Lee, 2019; Pellegrini et al., 2018a). Several studies have reported these factors to affect the compositions of chia, flaxseed, hemp, quinoa, perilla, and sesame seeds.…”

Section: Bioavailability Of Nutrients and Bioactives From Specialty Seedsmentioning

confidence: 99%

“…(2015) demonstrated that the nutritional compositions (carbohydrate, fat, protein, crude fiber, and minerals), total phenolics, total flavonoids, and antioxidant activities of white and brown perilla seeds were significantly different. In another study, Kim and Lee (2019) evaluated the phenolic compositions of cultivated and wild Korean perilla seeds. The cultivated perilla seeds had a significantly higher content of rosmarinic acid, rosmarinic acid‐3‐ O ‐glucoside, and chrysoeriol, whereas wild perilla seed had a significantly higher luteolin, apigenin, and caffeic acid contents.…”

Section: Bioavailability Of Nutrients and Bioactives From Specialty Seedsmentioning

confidence: 99%

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Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Alasalvar

Chang

Bolling

et al. 2021

Comp Rev Food Sci Food Safe

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Seeds play important roles in human nutrition and health since ancient time. The term “specialty” has recently been applied to seeds to describe high‐value and/or uncommon food products. Since then, numerous studies have been conducted to identify various classes of bioactive compounds, including polyphenols in specialty seeds. This review discusses nutrients, fat‐soluble bioactives, polyphenols/bioactives, antioxidant activity, bioavailability, health benefits, and safety/toxicology of commonly consumed eight specialty seeds, namely, black cumin, chia, hemp, flax, perilla, pumpkin, quinoa, and sesame. Scientific results from the existing literature published over the last decade have been compiled and discussed. These specialty seeds, having numerous fat‐soluble bioactives and polyphenols, together with their corresponding antioxidant activities, have increasingly been consumed. Hence, these specialty seeds can be considered as a valuable source of dietary supplements and functional foods due to their health‐promoting bioactive components, polyphenols, and corresponding antioxidant activities. The phytochemicals from these specialty seeds demonstrate bioavailability in humans with promising health benefits. Additional long‐term and well‐design human intervention trials are required to ascertain the health‐promoting properties of these specialty seeds.

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Section: Polyphenols and Other Bioactives In Specialty Seedsmentioning

confidence: 99%

Section: Bioavailability Of Nutrients and Bioactives From Specialty Seedsmentioning

confidence: 99%

Section: Bioavailability Of Nutrients and Bioactives From Specialty Seedsmentioning

confidence: 99%

See 1 more Smart Citation

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Alasalvar

Chang

Bolling

et al. 2021

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

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“…Low IC50 values against both monophenolase and diphenolase activty of mushroom tyrosinase have been very recently reported for p-coumaric and caffeic acid [66], belonging to the cinammic acid family ( Figure 7). The IC50 values together with structural formulas for other phenolic compounds widely distributed in nature that have been the subject of studies that appeared in the last five years [53,62,63,[67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82] Low IC 50 values against both monophenolase and diphenolase activty of mushroom tyrosinase have been very recently reported for p-coumaric and caffeic acid [66], belonging to the cinammic acid family ( Figure 7). Moving to simple phenols, significant inhibition activity has been described for 4-hydroxybenzyl alcohol (IC50 = 6 μM) [61] and isoeugenol (IC50 = 33.3 μM) [62], which would appear more efficient than resorcinol [55] or rhododendrol [63] themselves.…”

Section: Natural Phenolic Inhibitors Of Mushroom Tyrosinasementioning

confidence: 99%

“…Low IC50 values against both monophenolase and diphenolase activty of mushroom tyrosinase have been very recently reported for p-coumaric and caffeic acid [66], belonging to the cinammic acid family (Figure 7). The IC50 values together with structural formulas for other phenolic compounds widely distributed in nature that have been the subject of studies that appeared in the last five years [53,62,63,[67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82] The IC 50 values together with structural formulas for other phenolic compounds widely distributed in nature that have been the subject of studies that appeared in the last five years [53,62,63,[67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82] are also reported in Figures 4-8.…”

Section: Natural Phenolic Inhibitors Of Mushroom Tyrosinasementioning

confidence: 99%

Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances

2019

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One of the most common approaches for control of skin pigmentation involves the inhibition of tyrosinase, a copper-containing enzyme which catalyzes the key steps of melanogenesis. This review focuses on the tyrosinase inhibition properties of a series of natural and synthetic, bioinspired phenolic compounds that have appeared in the literature in the last five years. Both mushroom and human tyrosinase inhibitors have been considered. Among the first class, flavonoids, in particular chalcones, occupy a prominent role as natural inhibitors, followed by hydroxystilbenes (mainly resveratrol derivatives). A series of more complex phenolic compounds from a variety of sources, first of all belonging to the Moraceae family, have also been described as potent tyrosinase inhibitors. As to the synthetic compounds, hydroxycinnamic acids and chalcones again appear as the most exploited scaffolds. Several inhibition mechanisms have been reported for the described inhibitors, pointing to copper chelating and/or hydrophobic moieties as key structural requirements to achieve good inhibition properties. Emerging trends in the search for novel skin depigmenting agents, including the development of assays that could distinguish between inhibitors and potentially toxic substrates of the enzyme as well as of formulations aimed at improving the bioavailability and hence the effectiveness of well-known inhibitors, have also been addressed.

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Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics

et al. 2020

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The health-promoting benefits of medicine and food homology (MFH) are known for thousands of years in China. However, active compounds and biological mechanisms are unclear, greatly limiting clinical practice of MFH. The advent of gut microbiota analysis and metabolomics emerge as key tools to discover functional compounds, therapeutic targets, and mechanisms of benefits of MFH. Such studies hold great promise to promote and optimize functional efficacy and development of MFH-based products, for example, foods for daily dietary supplements or for special medical purposes. In this review, we summarized pharmacological effects of 109 species of MFH approved by the Health and Fitness Commission in 2015. Recent studies applying genome sequencing of gut microbiota and metabolomics to explain the activity of MFH in prevention and management of health consequences were extensively reviewed. We discussed the potentiality in future to decipher functional activities of MFH by applying metabolomics-based polypharmacokinetic strategy and multiomics technologies. The needs for personalized MFH recommendations and comprehensive databases have also been highlighted. This review emphasizes current achievements and challenges of the analysis of gut microbiota and metabolomics as a new avenue to understand MFH. K E Y W O R D S gut microbiota, medicine and food homology, metabolomics, multiomics technology Abbreviations: IBD, inflammatory bowel disease; LPS, lipopolysaccharide; MFH, medicine and food homology; SCFA, short-chain fatty acid; TCMIO, a comprehensive database of traditional Chinese medicine on immuno-oncology; WEGL, water extract of Ganoderma lucidum mycelium This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Comparative evaluation of phenolic phytochemicals from perilla seeds of diverse species and screening for their tyrosinase inhibitory and antioxidant properties

Cited by 19 publications

References 44 publications

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances

Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics

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