Comparative evaluation of Platelet Rich Plasma (PRP) versus Platelet Rich Fibrin (PRF) scaffolds in regenerative endodontic treatment of immature necrotic permanent maxillary central incisors: A double blinded randomized controlled trial

Rizk, Hazim Mohamed; Al-Deen, Mohamed Sherif Mohamed Salah; Emam, Asmaa Aly

doi:10.1016/j.sdentj.2019.09.002

Cited by 36 publications

(70 citation statements)

References 32 publications

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“…Although the impact of PRF on healing of the periapical lesions in immature necrotic teeth has been discussed by many researchers, the results are not unequivocal [22,23]. PRF may be considered as an ideal bioscaffold to increase proliferation and differentiation of cells that take part in the process of tissue repair [24]. Moreover, it has been found that reduction of the relative centrifugal force improves the regenerative potential of the PRF-based matrices [25].…”

Section: Discussionmentioning

confidence: 99%

Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: Case Reports

Machut

Zółtowska

Pawłowska

et al. 2021

IJMS

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Platelet-rich fibrin (PRF) is an autologous blood concentrate obtained without anticoagulants by centrifugation of patients’ peripheral venous blood. PRF is considered to enhance the formation of new bone. The aim of this manuscript was to present two case reports of permanent teeth with closed apexes with periapical lesions, treated endodontically with the use of PRF. The root canals were mechanically cleaned and shaped with NiTi files and irrigated with 5.25% sodium hypochlorite (NaOCl), 40% citric acid (CA), and triple distillated water. Before the canal systems were obturated, A-PRF was used as a scaffold and was placed below the cementodentinal junction with hand pluggers. Cone beam computerized tomography (CBCT) was used to assess the resolutions of periapical radiolucencies. After 6 months, the measurements of both periapical lesions were significantly reduced. Although the performed root canal treatments (RCTs) can definitely be recognized as successful, it must be emphasized that mechanical shaping and cleaning of the root canals with special disinfecting solutions significantly affect the clinical efficacy of RCT. It seems impossible to state that PRF played a leading role in the healing process of the presented periapical lesions. Further studies must be performed to assess whether RCT of mature teeth with an additional PRF application is superior to RCT performed alone.

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Section: Discussionmentioning

confidence: 99%

Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: Case Reports

Machut

Zółtowska

Pawłowska

et al. 2021

IJMS

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“…PRF scaffolds have shown evidence of apical closure, resolution of apical radiolucency, continued root lengthening, and thickening of dentinal walls in immature permanent teeth with necrotic pulps [135][136][137][138]. Similarly, PRP scaffolds showed the same outcomes as PRF scaffolds, with no statistically significant differences between the two [137,139]. Bio-Gide collagen membranes (Geistlich, Wolhussen, Switzerland) have shown to promote the development of dentinal wall in the middle third of the root, thus reinforcing the root to prevent cervical root fractures [140].…”

Section: Regenerative Endodonticsmentioning

confidence: 99%

“…To regain nerve function after REP takes a long time. Therefore, a longer follow-up period may be required for pulp sensibility tests to display a positive result [138,139].…”

Section: Regenerative Endodonticsmentioning

confidence: 99%

Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine

Munguia-Lopez

Cho

et al. 2021

Molecules

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Dental, oral, and craniofacial (DOC) regenerative medicine aims to repair or regenerate DOC tissues including teeth, dental pulp, periodontal tissues, salivary gland, temporomandibular joint (TMJ), hard (bone, cartilage), and soft (muscle, nerve, skin) tissues of the craniofacial complex. Polymeric materials have a broad range of applications in biomedical engineering and regenerative medicine functioning as tissue engineering scaffolds, carriers for cell-based therapies, and biomedical devices for delivery of drugs and biologics. The focus of this review is to discuss the properties and clinical indications of polymeric scaffold materials and extracellular matrix technologies for DOC regenerative medicine. More specifically, this review outlines the key properties, advantages and drawbacks of natural polymers including alginate, cellulose, chitosan, silk, collagen, gelatin, fibrin, laminin, decellularized extracellular matrix, and hyaluronic acid, as well as synthetic polymers including polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), poly (ethylene glycol) (PEG), and Zwitterionic polymers. This review highlights key clinical applications of polymeric scaffolding materials to repair and/or regenerate various DOC tissues. Particularly, polymeric materials used in clinical procedures are discussed including alveolar ridge preservation, vertical and horizontal ridge augmentation, maxillary sinus augmentation, TMJ reconstruction, periodontal regeneration, periodontal/peri-implant plastic surgery, regenerative endodontics. In addition, polymeric scaffolds application in whole tooth and salivary gland regeneration are discussed.

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“…In a clinical study on 30 patients with maxillary necrotic permanent immature central incisors, treating one group with PRP and the other with PRF scaffolds, teeth survived during the 12-month follow-up period. The teeth revealed marginal increase in radiographic root width and length, an increased periapical bone density, and a narrowing in apical diameter [113]. Other studies compared the effect of PRF, PRP, and the blood clot technique in the revascularization of necrotic teeth with open apex, demonstrating continued root development and maintenance of functionality, following different follow-up periods, yet with some teeth not responding to vital testing [2,5,6,[114][115][116][117][118][119][120][121][122].…”

Section: Stem Cells Internationalmentioning

confidence: 99%

Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration

Ahmed

Abouauf

AbuBakr

et al. 2021

Stem Cells International

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Regenerative dentistry has paved the way for a new era for the replacement of damaged dental tissues. Whether the causative factor is dental caries, trauma, or chemical insult, the loss of the pulp vitality constitutes one of the major health problems worldwide. Two regenerative therapies were introduced for a fully functional pulp-dentin complex regeneration, namely, cell-based (cell transplantation) and cell homing (through revascularization or homing by injection of stem cells in situ or intravenously) therapies, with each demonstrating advantages as well as drawback, especially in clinical application. The present review is aimed at elaborating on these two techniques in the treatment of irreversibly inflamed or necrotic pulp, which is aimed at regenerating a fully functional pulp-dentin complex.

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Comparative evaluation of Platelet Rich Plasma (PRP) versus Platelet Rich Fibrin (PRF) scaffolds in regenerative endodontic treatment of immature necrotic permanent maxillary central incisors: A double blinded randomized controlled trial

Cited by 36 publications

References 32 publications

Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: Case Reports

Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: Case Reports

Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine

Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration

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