Comparative evaluation of platelet-rich fibrin versus beta-tri-calcium phosphate in the treatment of Grade II mandibular furcation defects using cone-beam computed tomography

Siddiqui, Zeba; Jhingran, Rajesh; Bains, Vivek Kumar; Srivastava, Ruchi; Madan, Rohit; Rizvi, Iram

doi:10.4103/1305-7456.195160

Cited by 21 publications

(27 citation statements)

References 25 publications

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“…Seven abstracts were discarded due to the methodology not corresponding to the inclusion criteria; thus 15 full text papers were suitable for detailed examination; six articles were discarded according to the exclusion criteria after full text screening, and one article was excluded because some inconsistencies between the data reported in the tables and those reported in the text were found. In conclusion, eight studies were included in the systematic review [ 31 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…The studies were categorized based on the population characteristics as described in Table 2 , and on the clinical and laboratory parameters measured ( Table 3 ) and their findings. The PRF-centrifugation protocol was not homogeneous across the included studies and neither was the RCFmax (400× g for 10 [ 42 ] or 12 [ 45 , 47 ] minutes and 3000 rpm for 10 [ 31 , 43 , 46 , 48 ] or 12 [ 44 ] minutes). Non-standard types of centrifuges were used, and therefore the RCF was not comparable among them.…”

Section: Resultsmentioning

confidence: 99%

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Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis

Tarallo

Mancini

Pitzurra

et al. 2020

JCM

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In periodontitis patients, furcation defects are crucial sites to regenerate due to their complex anatomy. Various modern surgical techniques and use of biomaterials have been suggested in the literature. Among all, platelet-rich fibrin (PRF) has potential in tissue regeneration thanks to its role in the release of growth factors. Therefore, the purpose of this study was to evaluate the beneficial effect of the addition of PRF to open flap debridement (OFD) or as an adjuvant to other biomaterials such as bone grafts in the treatment of grade 2 mandibular furcation defects. Systematic research was carried out on the databases Medline, Scopus, Embase, and Cochrane Library and registered on PROSPERO (CRD42020167662). According to the PICO guidelines by Cochrane, randomized trials and prospective non-randomized trials were evaluated, with a minimum follow-up period of 6 months. The inclusion criteria were the absence of systemic diseases, non-smoking patients, and a population aged from 18 to 65 years. Vertical pocket probing depth (PPD), vertical clinical attachment level (VCAL), and gingival recession (REC) were the primary outcomes. Vertical furcation depth (VFD), and the percentage of bone defect fill (%v-BDF) were considered as secondary outcomes. A meta-analysis of the primary and secondary outcomes was performed. Publication bias was assessed through a funnel plot. Eighty-four articles were initially extracted. Eight randomized clinical trials were analyzed according to the exclusion and inclusion criteria. The Quality assessment instrument (QAI) revealed four articles at low risk of bias, one at moderate, and three at high risk of bias. The metanalysis showed significant data regarding PPD, VCAL, VFD and %v-BDF in the comparison between PRF + OFD vs. OFD alone. The adjunct of PRF to a bone graft showed a significant difference for VCAL and a not statistically significant result for the other involved parameters. In conclusion, the adjunctive use of PRF to OFD seems to enhance the periodontal regeneration in the treatment of grade 2 furcation defects. The combination of PRF and bone graft did not show better clinical results, except for VCAL, although the amount of literature with low risk of bias is scarce. Further well-designed studies to evaluate the combination of these two materials are therefore needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis

Tarallo

Mancini

Pitzurra

et al. 2020

JCM

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“…15 Other molecules, such as endothelial growth factors (including VEGF), act as avid stimulators of angiogenesis, thus increasing blood vessel synthesis. 12,45 Platelets and leukocytes are involved in VEGF expression; they are at their highest concentrations in the first hours after the clotting process, and VEGF levels gradually increase during the tissue healing process. 43 Rapid neovascularization is vital to tissue repair and regeneration, since angiogenesis enables the migration of tissue cells adjacent to the matrix, which, in turn, enables the repopulation of the injured area and the start of tissue repair.…”

Section: Molecular Parameters: Discussionmentioning

confidence: 99%

Platelet-Rich Fibrin in Coverage of Gingival Recession: A Systematic Review and Meta-Analysis

et al. 2020

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This systematic review and meta-analysis sought to evaluate the efficacy of platelet-rich fibrin (PRF) membranes versus subepithelial connective tissue grafts (SCTGs) in the coverage of Miller class I and II gingival recessions. After the inclusion and exclusion criteria were applied, the quality of seven articles (Cohen’s Kappa = 0.9) was evaluated using the Jadad scale. The MEDLINE/PubMed, Cochrane, and Web of Science databases were consulted, and manual searches were performed in the most popular periodontics journals. The studies included considered a total of 122 patients, 203 surgical fields on which SCTGs were used, and 205 surgical fields on which PRF was used. The parameters analyzed were probing depth, clinical attachment level, gingival recession, and keratinized mucosa. The minimum follow-up period accepted was 6 months. A statistically significant difference between the SCTG and PRF groups was found only in the case of keratinized mucosa. However, gingival recession, clinical attachment level, and probing depth parameters in the PRF group were found to be statistically equal to those of the SCTG group (the gold standard) (p ≥0.05). PRF membranes were determined to be a promising alternative to autogenous gingival grafts in the treatment of Miller class I and II gingival recessions.

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“…Results of the present study were in accordance with a study by Nagasri M et al, 2016 (21) who concluded that there were improvement on probing depth, Clinical attachment level and radiograghic bone fill when using NcHA bone graft +Platelet rich fibrin in intrabony defect, and a study by Enas ahmed et al (4) who concluded that Adjunctive use of PRF membrane in combination with NcHA bone graft in treatment of intrabony defect resulted in clinically, radiographically statistically significant compared with NcHA bone graft alone, in terms of PPD reduction, CAL gain and increase BD. In another study by Rahman Siddiqui et al 2016 (22) vertical and horizontal height of furcation was better when using PRF in treatment of class II furcation involvement.…”

Section: Discussionmentioning

confidence: 91%

Platelet Rich Fibrin Combined with Nano Crystalline Hydroxyappatite in Treatment of Grade II Mandibular Furcation Defect

Edrees

Maher

Hassan

2019

Al-Azhar Assiut Dental Journal

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Aim: This study aims to evaluate the effect of Platelet Rich Fibrin combined with Nano crystalline Hydroxy appatite bone graft on grade II mandibular furcation involvement. Subjects and methods: Thirty patients having grade II mandibular furcation defects, with vertical probing depth (VPD) ≥5mm and horizontal clinical attachment level (HCAL) ≥3mm. Following phase I therapy were classified into two groups, group1 received NcHA bone graft and group 2 received NcHA+PRF. Clinical and radiographic parameters were recorded at baseline, 6 and 12 months postoperatively. Results: Both treatment groups showed a significant probing pocket depth (PPD) reduction, clinical attachment gain, increase bone density 12-months after surgery compared with baseline. However, there was a highly significant PPD reduction and clinical attachment gain when PRF was added to NcHA. Conclusion: The NcHA bone graft in combination with PRF demonstrated clinical advantages beyond that achieved by the NcHA alone. Different methods of furcation management therapy include nonsurgical periodontal therapy, open flap debridement, furcation plasty, root resection\ Hemisection, regenerative techniques (Guided Tissue Regeneration, bone graft, Enamel Matrix Derivatives) and tunneling. (3)

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Comparative evaluation of platelet-rich fibrin versus beta-tri-calcium phosphate in the treatment of Grade II mandibular furcation defects using cone-beam computed tomography

Cited by 21 publications

References 25 publications

Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis

Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis

Platelet-Rich Fibrin in Coverage of Gingival Recession: A Systematic Review and Meta-Analysis

Platelet Rich Fibrin Combined with Nano Crystalline Hydroxyappatite in Treatment of Grade II Mandibular Furcation Defect

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