2024
DOI: 10.1016/j.adro.2023.101355
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Comparative Evaluation of Proton Therapy and Volumetric Modulated Arc Therapy for Brachial Plexus Sparing in the Comprehensive Reirradiation of High-Risk Recurrent Breast Cancer

J. Isabelle Choi,
Beryl McCormick,
Peter Park
et al.
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Cited by 1 publication
(2 citation statements)
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“…Brachial plexus injury can result in significant detrimental clinical manifestations, including arm loss of movement, weakness, paresthesia, and pain. Intensity-modulated proton therapy (IMPT) can reduce the dose delivered to the brachial plexus in the setting of reRT while maintaining dose coverage to the surrounding target tissue to a greater degree than that achievable with advanced conformal photon techniques such as VMAT [50]. Therefore, for patients requiring a repeat course of radiation to areas that overlap with a previously irradiated brachial plexus, such as in breast cancer patients who require repeat regional nodal irradiation, proton therapy is indicated.…”
Section: Patient Selection and Rationale For Proton Therapymentioning
confidence: 99%
See 1 more Smart Citation
“…Brachial plexus injury can result in significant detrimental clinical manifestations, including arm loss of movement, weakness, paresthesia, and pain. Intensity-modulated proton therapy (IMPT) can reduce the dose delivered to the brachial plexus in the setting of reRT while maintaining dose coverage to the surrounding target tissue to a greater degree than that achievable with advanced conformal photon techniques such as VMAT [50]. Therefore, for patients requiring a repeat course of radiation to areas that overlap with a previously irradiated brachial plexus, such as in breast cancer patients who require repeat regional nodal irradiation, proton therapy is indicated.…”
Section: Patient Selection and Rationale For Proton Therapymentioning
confidence: 99%
“…However, excessive dose escalation may lead to severe toxicities. For example, a study attempting to determine the optimal reRT dose for recurrent esophageal squamous cell carcinoma found that a reRT dose of above Cancers 2023, 15, 5722 10 of 15 50 Gy was associated with improved OS, but doses above 60 Gy were associated with severe toxicities [79]. Studies attempting to determine the optimal reRT dose for breast cancer would be informative to the development of clinical guidelines.…”
Section: Future Directionsmentioning
confidence: 99%