Comparative evaluation of remineralization potential of nanohydroxyapatite crystals, bioactive glass, casein phosphopeptide-amorphous calcium phosphate, and fluoride on initial enamel lesion (scanning electron microscope analysis) – An in vitro study

Geeta, RD; Vallabhaneni, Saritha; Fatima, Kainath

doi:10.4103/jcd.jcd_62_20

Cited by 16 publications

(22 citation statements)

References 18 publications

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“…This was in accordance with Manchery et al, 13 where they concluded that there was no statistical significance found between fluoride, nano-hydroxyapatite, and bioactive glass. But this was disagreeing with Geeta et al, 14 as they concluded that there was a significant difference between nano-hydroxyapatite, bioactive glass, and fluoride. This may be due to the use of the material in paste form and applying the materials three times/day, not two with taking into consideration using surface microhardness as an assessment method.…”

Section: Mansoura Journal Of Dentistrymentioning

confidence: 83%

Remineralizing Efficacy of Chitosan-Based Nanomaterials on Artificially Induced Incipient Carious Lesions

2021

Mansoura Journal of Dentistry

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Objective: Assessment of the remineralizing efficacy of Bioactive glass-chitosan and Hydroxy Apatite-Chitosan on artificial white spot lesions. Materials and methods: Sixty extracted human permanent teeth were selected for the study. Specimens were divided into four groups: group 1: fluoride varnish (Voco), group 2: Bioactive Glass-Chitosan varnish (Nano gate company), group 3: Hydroxy Apatite-Chitosan varnish (Nano gate company), group 4: control (treated with remineralizing solution). Artificial carious lesions were induced in all the specimens and treated with respective varnishes twice daily for 7 days. The DIAGNOdent pen (Kavo DIAGNOdent pen 2190) readings were taken, and the surface characteristics of the enamel specimens were evaluated by SEM at baseline, after demineralization and after remineralization. Results: SEM evaluation showed favourable surface changes in all the four study groups after remineralization therapy. Intragroup comparison of DIAGNOdent readings showed a highly significant difference between baseline, post demineralization, and post remineralization values. However, the intergroup comparison was statistically nonsignificant. Conclusion: All test agents were comparable in their remineralization potential.

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Section: Mansoura Journal Of Dentistrymentioning

confidence: 83%

Remineralizing Efficacy of Chitosan-Based Nanomaterials on Artificially Induced Incipient Carious Lesions

2021

Mansoura Journal of Dentistry

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“…Demineralization is one of the causes of tooth loss that causes molecular alterations in apatite minerals of tooth, to an obvious demineralized area, association of dentin, and ultimate cavitation. 15 Following the end of fixed orthodontic treatment, the most difficult problem is the control of enamel demineralization. Usually, surface treatment of demineralization was concerned about the mineral loss and mineral gain to the tooth.…”

Section: Discussionmentioning

confidence: 99%

“…11 A new remineralizing agent CPP-ACP, is a derivative of milk casein, has ability to absorb through enamel surface. 14,15 It preserves supersaturated position of enamel mineral, phosphate and calcium in plaque and encourage remineralization, 16 delays the growth of biofilm plus hinders the adhesion of bacteria to tooth surface. 17,18 It works like buffering agent that stop a fall of pH and regulate acid-base balance.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Remineralization Effect of Casein Phosphopeptide Amorphous Calcium Phosphate and Sodium Fluoride on Enamel Surface after Orthodontic Debonding: An In vitro study

Jawaid¹,

Shaheen²,

Ilyas³

et al. 2022

J Pak Dent Assoc

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OBJECTIVE: To compare the result of "casein phosphopeptide amorphous calcium phosphate" with "sodium fluoride" (900 ppm) in remineralization of enamel after orthodontic debonding. METHODOLOY: This study was performed on premolars. Teeth were distributed into 3 groups A, B and C. The baseline microhardness of samples was measured. To create artificial demineralization, all samples were dipped in demineralizing solution. Surface microhardness (SMH) was re-measured for demineralization. Then, CPP-ACP was applied on teeth of gp B and NaF (900 ppm) was applied on teeth of gp C for remineralization. All teeth were cycled between deionized water and surface treatment for 12 weeks. The SMH of gp B and gp C was re-measured for remineralization. Paired t-test and Independent t-test were practiced to match MH before and after demineralization while keeping P value < 0.05. One way ANOVA was practiced to match mean difference in baseline MH and after demineralization. RESULTS: The baseline SMH of enamel decrease after demineralization. After application of test materials, mean SMH increased by 230.2 VHN and 207.5 VHN respectively. The %age of SMHR reveal the recovery rate of 41.2% in CPP-ACP and 19.1% in NaF group. CONCLUSION: For treating post orthodontic demineralized lesions, a remineralizing cream having casein phosphopeptide stabilized amorphous calcium phosphate is useful with some mineral and aesthetic improvements. KEYWORDS: Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP), Sodium Fluoride (NaF), Surface Microhardness (SMH), Vickers Hardness Number (VHN), Rmineralization.

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“…Nano hydroxyapatite's morphology and crystalline structure (Nano HA) is similar to apatite crystal of dental enamel can be seen as a substitute for the natural mineral constituent of enamel, favoring biomimetic remineralization (Zhang & Deng, 2015). In this way, Geeta, Vallabhaneni and Fatima, (2020) demonstrated in their research the potential for remineralization of nano HA in a pH cycling test, comparing it with bioactive glass (SHY-NM), calcium casein-amorphosphate phosphate (CPP-ACP) and fluoride in initial enamel caries lesions. Nano HA had the highest surface hardness, demonstrating a higher enamel remineralization potential than fluoride.…”

Section: Nano Hydroxyapatitementioning

confidence: 99%

Bioactive agents with biomimmetic remineralizing action

Tomaz

Santos

Pereira

2022

RSD

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Dental caries is considered by the WHO to be the second most common disease in the world. Considering that its action is due to enamel demineralization carried out through the metabolism of carbohydrates by dental biofilm bacteria, the use of fluoride toothpastes was established as an effective method of control. Fluoride toothpastes are an integral part of individual care to prevent caries. However, even with its proven effectiveness, there is still a prevalence of the disease. Therefore, different bioactive agents are being studied, looking for an action that is fluoride auxiliary, equivalent or even better. This review aimed to carry out a bibliographic survey of the last five years on the different bioactive agents used in the biomimetic remineralization process of different dental tissues and in the modulation of caries disease, both in vitro and in vivo studies. Different bioactive agents used for enamel remineralization were addressed in this review, including various forms of calcium phosphate as well as self-assembling peptides. Of the 275 studies found, 45 studies met the inclusion criteria and were used for this review. Published studies demonstrate the potential of different bioactive agents in the biomimetic remineralization of enamel. However, further studies are needed to further substantiate existing results and to extend and refine the application of these agents in modern oral hygiene.

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Comparative evaluation of remineralization potential of nanohydroxyapatite crystals, bioactive glass, casein phosphopeptide-amorphous calcium phosphate, and fluoride on initial enamel lesion (scanning electron microscope analysis) – An in vitro study

Cited by 16 publications

References 18 publications

Remineralizing Efficacy of Chitosan-Based Nanomaterials on Artificially Induced Incipient Carious Lesions

Remineralizing Efficacy of Chitosan-Based Nanomaterials on Artificially Induced Incipient Carious Lesions

Comparison of Remineralization Effect of Casein Phosphopeptide Amorphous Calcium Phosphate and Sodium Fluoride on Enamel Surface after Orthodontic Debonding: An In vitro study

Bioactive agents with biomimmetic remineralizing action

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