Comparative Evaluation of Silicone Hydrogel Contact Lenses and Autologous Serum for Management of Sjögren Syndrome-Associated Dry Eye

Abstract

Balafilcon A silicone hydrogel contact lenses as a BCL were effective in the management of SS-associated dry eye. Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02147509.

Combined use of 0.1% fluorometholone and meibomian gland expression improves symptoms of moderate and severe dry eye disease, even in patients with systemic immune disease

“…We have also analyzed data of 15 patients (6 SS) with SID. The results are in concordance with previous studies [29,30]. Although the patients with DED had improvements in their ocular surface signs (fluorescein staining score and R-Scan), meibomian gland function (meibum score and tear BUT) and symptoms (OSDI questionnaire score), these improvements were still less than those in patients without SID.…”

Autologous serum eye drops for dry eye

“…We identified one potentially relevant record by searching the Science Citation Index for trials that cited included studies. Of 297 unique records identified, we excluded 291 records by screening titles and abstracts, and five upon review of full-text reports (Fea 2016; Hwang 2014; Li 2015; Mukhopadhyay 2015; NCT02752763). We included one new trial (Celebi 2014) in the update of this review.…”

“…Most excluded studies were non-randomized studies or reviews. We excluded five RCTs because investigators did not compare AS versus artificial tears or placebo (Fea 2016; Jaksche 2005; Li 2015; Noble 2004; Yoon 2007). …”

Dysfunctional tear syndrome

“…Symptomatic relief and a reduction of the expression of inflammatory markers in the tear film (MMPs) were observed in association with the use of bandage contact lenses to promote corneal epithelial healing (level II) [159]. Significant improvements in best-corrected visual acuity, corneal staining, and ocular symptoms were observed in patients with severe dry eye due to Sjögren syndrome who used bandage contact lenses (level II) [160]. Bandage contact lenses are also recommended as a treatment option for the management of ocular conditions associated with aqueous deficiency, such as filamentary keratitis [161].…”