Comparative evaluation of silver nanoparticles and 5.25% sodium hypochlorite for rapid chairside decontamination of artificially infected gutta-percha with Escherichia coli: An In vitro Study

Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review

“…AgNPs, at a concentration of 50 µg/mL, decreased but did not completely prevent proliferation of bacteria. However, AgNPs were highly effective against E. coli in 70 µg/mL concentration, and demonstrated an antimicrobial effect similar to that of 5.25% NaOCl at a 750-times-lower concentration [ 12 ]. The antibacterial effectiveness of AgNPs as a final irrigant on E. faecalis is similar to that of NaOCl.…”

“…The surface charge of nanoparticles is considered to contribute to their antibacterial activity through electrostatic interactions [ 11 ], subsequently altering membrane permeability and resulting in cell death [ 12 ]. Thus, positively-charged nanoparticles have significant antimicrobial effects against all the tested bacterial species [ 11 ].…”

“…AgNPs have a much greater effect on Gram-negative than Gram-positive bacteria due to their cell membrane composition [ 14 ]. Gram-negative bacteria have a relatively thinner cell membrane and are, therefore, more susceptible to physical degradation [ 12 ]. The antimicrobial effects of AgNPs on Gram-negative bacteria depend on the silver concentration and are closely correlated with the formation of pits on the cell membrane [ 12 ].…”

“…Gram-negative bacteria have a relatively thinner cell membrane and are, therefore, more susceptible to physical degradation [ 12 ]. The antimicrobial effects of AgNPs on Gram-negative bacteria depend on the silver concentration and are closely correlated with the formation of pits on the cell membrane [ 12 ]. The inhibitory effect of AgNPs on Enterococcus faecalis ( E. faecalis ), which is the main bacteria isolated from cases of persistent root canal infections, reinfections, and treatment failure, has been well confirmed.…”