Comparative evaluation of starches obtained from Dioscorea species as intragranular tablet disintegrant

Okunlola, Adenike; Odeku, Oluwatoyin A.

doi:10.1016/s1773-2247(08)50085-2

Cited by 12 publications

(11 citation statements)

References 12 publications

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“…1 while the tensile strength at relative density of 0.80, which is representative of commercial paracetamol tablets, are presented in Table 1. The tensile strength of the paracetamol tablets decreased with increase in the concentration of the starches with tablets and the values were higher than those previously reported for the native forms of the starch disintegrants (Okunlola and Odeku, 2008). Acid hydrolysis has been shown to remove the amorphous regions of the starch resulting in the more crystalline acid modified starch granules being forced closer together during compression which will result in stronger packing of the granules and an increase in the tensile strength of the tablets (Atichokudomchai et al, 2001;Odeku and Picker-Freyer, 2009a).…”

Section: Resultsmentioning

confidence: 74%

“…disintegration within 15 min. Previous studies of the disintegrant properties of the native forms of these starches incorporated intragranularly at a concentration of 10%w/w in chloroquine tablet formulations have shown that the disintegration time of the tablets was 8.2 and 9.2 min for water and white yam starches, respectively (Okunlola and Odeku, 2008). Statistical analysis showed that the disintegration times of the acid modified starches were significantly (p < 0.01) lower than those of the native forms of the starches.…”

Section: Resultsmentioning

confidence: 87%

“…Starch is one of the earliest known disintegrants although in recent times, super disintegrants such as sodium starch glycolate (Explotab, Primogel) and sodium carboxymethyl cellulose (Ac-Di-Sol) offer significant improvements over the native starches. Starches obtained locally from different botanical sources have also been evaluated as disintegrants in commercial tablets generally in the concentration range of 2-10%w/w (Adebayo and Itiola, 1998;Alebiowu and Itiola, 2003;Odeku and Alabi, 2007;Okunlola and Odeku, 2008;Odeku et al, 2009). Starch disintegrant may be incorporated to the powder mixture before granulation (internal, intra-or endo-disintegrant) or as a dry powder to the prepared granules (external, extra-or exo-disintegrant) or it may be added both internally and externally (Pilpel et al, 1978;Kamp et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

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Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches

Odeku¹,

Akinwande²

2012

Saudi Pharmaceutical Journal

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Acid modified starches obtained from two species of yam tubers namely white yam - Dioscorea rotundata L. and water yam - D. alata L. DIAL2 have been investigated as intra- and extra-granular disintegrants in paracetamol tablet formulations. The native starches were modified by acid hydrolysis and employed as disintegrant at concentrations of 5 and 10% w/w and their disintegrant properties compared with those of corn starch BP. The tensile strength and drug release properties of the tablets, assessed using the disintegration and dissolution (t 50 and t 80 - time required for 50% and 80% of paracetamol to be released) times, were evaluated. The results showed that the tensile strength and the disintegration and dissolution times of the tablets decreased with increase in the concentration of the starch disintegrants. The acid modified yam starches showed better disintegrant efficiency than corn starch in the tablet formulations. Acid modification appeared to improve the disintegrant efficiency of the yam starches. Furthermore, tablets containing starches incorporated extragranularly showed faster disintegration but lower tensile strength than those containing starches incorporated intragranularly. This emphasizes the importance of the mode of incorporation of starch disintegrant.

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Section: Resultsmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches

Odeku¹,

Akinwande²

2012

Saudi Pharmaceutical Journal

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“…When the starch powders were used as exodisintegrants in chloroquine tablet formulations, D. alata and D. rotundata starches exhibited better disintegrant efficiency than corn, while D. dumetorum and D. oppositifolia starches showed less disintegrant efficiencies than official corn starch. The authors concluded that the starches from the four species of yam compared favorably and in some cases showed better efficiency as binder and disintegrant than corn starch and could be further developed for use in commercial tablet formulation [17].…”

Section: Yamsmentioning

confidence: 99%

Potentials of tropical starches as pharmaceutical excipients: A review

Odeku

2012

Starch Stärke

103

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Tropical roots and tubers, grains, cereals, and fruits are crops that have served as staple foods for millions of people throughout the hot and humid regions of the world for many centuries. Some of these crops grow in abundance with little or no artificial input. These tropical crops contain starch of as one their major component, which has made them good sources of starch that could be used as pharmaceutical excipients. In recent time, some of these starches have been investigated for use as fillers, glidants, binders, and disintegrants in pharmaceutical tablet formulations. The diversity of the starches from these plants has shown that some of the starches can be used in place of commercially available chemically modified starches. Their application as excipients can add value to some of these neglected and underutilized crops and also provide starch with special properties for specific applications. This review summarizes the present knowledge on the starches extracted from tropical plants that have been evaluated as pharmaceutical excipients and their potential usefulness, with a view to providing suggestions for needed research to adopt the utilization of these starches in the pharmaceutical industry.

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“…8 The compactibility of the starch appeared to be related to the particle size (25.3 µm), shape (oval) and amylose content (27.33%) of the starch. 9 In another study, the suitability and relative efficiency of water yam starch as disintegrant was investigated in comparison to official corn starch. 9 Water yam starch showed faster disintegration and release properties than corn starch when used as intragranular disintegrant in chloroquine phosphate tablets.…”

Section: Introductionmentioning

confidence: 99%

Effects of Water Yam and Corn Starches on the Interacting Variables Influencing the Disintegration of Chloroquine Phosphate Tablets

Okunlola

Odeku

2012

Dhaka Univ. J. Pharm. Sci

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ABSTRACT:The individual and effects of interaction of nature (X) and concentration (Y) of disintegrant and the relative density (Z) on the mechanical and release properties of chloroquine phosphate tablets were studied using a 2 3 factorial experimental design. Water yam starch ("low" level) and corn starch ("high" level) were used as disintegrants at concentrations of 5.0% and 20.0% w/w. The mechanical properties were assessed using the crushing strength (CS) and friability (F) and the release properties by the disintegration time (DT) and dissolution time (t 80 ).Increasing the concentration of disintegrants and the relative density of tablets resulted in increase in CS, but decrease

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Comparative evaluation of starches obtained from Dioscorea species as intragranular tablet disintegrant

Cited by 12 publications

References 12 publications

Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches

Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches

Potentials of tropical starches as pharmaceutical excipients: A review

Effects of Water Yam and Corn Starches on the Interacting Variables Influencing the Disintegration of Chloroquine Phosphate Tablets

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