Comparative Evaluation of Subgingivally Delivered 2% Curcumin and 0.2% Chlorhexidine Gel Adjunctive to Scaling and Root Planing in Chronic Periodontitis

Mallapragada, Siddharth; Singh, Preetvanti; Gupta, Radhika; Sinha, Arvind; Shree, Shanta; Sharma, Komal

doi:10.5005/jp-journals-10024-2828

Cited by 24 publications

(7 citation statements)

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“…It has been investigated for the treatment of minor recurrent aphthous stomatitis (RAS) and oral leukoplakia and as an adjunct in endodontic therapy, gingivitis treatment, and oral wound healing. Additionally, curcumin gel shows potential as an adjunctive therapy in periodontal treatment [ 92 , 93 , 94 , 96 , 97 , 99 , 104 , 116 , 117 , 118 ], reducing bone and root resorption during orthodontic treatment and enhancing the efficacy of scaling and root planing (SRP) in treating chronic periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and Clinical Applications

Omidian

Wilson

Chowdhury

2023

Gels

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Curcumin, a potent active compound found in turmeric and Curcuma xanthorrhiza oil, possesses a wide range of therapeutic properties, including antibacterial, anti-inflammatory, antioxidant, and wound healing activities. However, its clinical effectiveness is hindered by its low bioavailability and rapid elimination from the body. To overcome these limitations, researchers have explored innovative delivery systems for curcumin. Some promising approaches include solid lipid nanoparticles, nanomicelle gels, and transdermal formulations for topical drug delivery. In the field of dentistry, curcumin gels have shown effectiveness against oral disorders and periodontal diseases. Moreover, Pickering emulsions and floating in situ gelling systems have been developed to target gastrointestinal health. Furthermore, curcumin-based systems have demonstrated potential in wound healing and ocular medicine. In addition to its therapeutic applications, curcumin also finds use as a food dye, contraception aid, corrosion-resistant coating, and environmentally friendly stain. This paper primarily focuses on the development of gel compositions of curcumin to address the challenges associated with its clinical use.

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Section: Discussionmentioning

confidence: 99%

Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and Clinical Applications

Omidian

Wilson

Chowdhury

2023

Gels

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“…Based on this information, we would strongly recommend herbal mouthwashes as home prophylactic measures [ 66 ]. For instance, mouthwashes containing curcumin and the peppermint plant have antibacterial and bacterial growth inhibition properties when used to treat periodontal disease [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Microbiome Traits of Type 1 Diabetes and Phenylketonuria Patients in Latvia

et al. 2023

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Some metabolic disorder treatments require patients to follow a specific diet or to consume supplements that, over time, can lead to oral microbiome alterations. Well-known disorders requiring such treatment are phenylketonuria (PKU), an inborn error of amino acid metabolism, and type 1 diabetes (T1D), a metabolic disorder that requires a specific diet regimen. Therefore, the aim of this study was to investigate the oral health and microbiome characteristics that might contribute to caries activity and periodontal disease risk in PKU and T1D patients. In this cross-sectional study, 45 PKU patients, 24 T1D patients, and 61 healthy individuals between the ages of 12 and 53 years were examined. Their anamnestic data and dental status were assessed by one dentist. Microbial communities were detected from saliva-isolated DNA using 16S rRNA gene V3–V4 sequencing on Illumina MiSeq sequencing platform. Results revealed that the PKU patient group displayed the highest number of extracted teeth (on average 1.34), carious teeth (on average 4.95), and carious activity (44.44% of individuals) compared to the T1D and CTRL groups. The lowest numbers of filled teeth (on average 5.33) and extracted teeth (on average 0.63) per individual were observed in T1D patients. Gingivitis appeared more often in the T1D group; however, possible risk of periodontal disease was seen in both the T1D and PKU patient groups. The highest number of differentially abundant genera was detected in the PKU group (n = 20), with enrichment of Actinomyces (padj = 4.17 × 10−22), Capnocytophaga (padj = 8.53 × 10−8), and Porphyromonas (padj = 1.18 × 10−5) compared to the CTRL group. In conclusion, the dental and periodontal health of PKU patients was found to be significantly inferior compared to T1D patients and healthy controls. T1D patients showed early signs of periodontal disease. Several genera that correlate with periodontal disease development were found in both groups, thus suggesting that T1D and PKU patients should seek early and regular dental advice and be educated about proper oral hygiene practices.

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“…Moreover, a randomized, single-blinded clinical trial of gingival irrigation with 1% curcumin solution on days 7, 14, and 21 for 6 months reduced the bleeding score, PI score, and PPD in patients with chronic periodontitis . Studies have shown that the application of curcumin gel/strips effectively reduces CAL gain, GI, PI, PPD, SBI, SOD, RAL, and CFU in periodontitis. − In a randomized controlled split-mouth trial, Ivanaga and colleagues showed that irrigation with curcumin in the presence or absence of LED irradiation in patients with chronic periodontitis and T2D remarkably reduced the PI after 90–180 days of follow-up. This study also showed that curcumin irrigation alone or with LED irradiation reduced probing depth and clinical attachment gain, although the differences were not statistically significant .…”

Section: Clinical Trials Of Turmeric and Curcuminmentioning

confidence: 99%

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

Kunnumakkara

Hegde

Dey

et al. 2023

ACS Pharmacol. Transl. Sci.

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Turmeric (Curcuma longa) has been used for thousands of years for the prevention and treatment of various chronic diseases. Curcumin is just one of >200 ingredients in turmeric. Almost 7000 scientific papers on turmeric and almost 20,000 on curcumin have been published in PubMed. Scientific reports based on cell culture or animal studies are often not reproducible in humans. Therefore, human clinical trials are the best indicators for the prevention and treatment of a disease using a given agent/drug. Herein, we conducted an extensive literature survey on PubMed and Scopus following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The keywords "turmeric and clinical trials" and "curcumin and clinical trials" were considered for data mining. A total of 148 references were found to be relevant for the key term "turmeric and clinical trials", of which 70 were common in both PubMed and Scopus, 44 were unique to PubMed, and 34 were unique to Scopus. Similarly, for the search term "curcumin and clinical trials", 440 references were found to be relevant, of which 70 were unique to PubMed, 110 were unique to Scopus, and 260 were common to both databases. These studies show that the golden spice has enormous health and medicinal benefits for humans. This Review will extract and summarize the lessons learned about turmeric and curcumin in the prevention and treatment of chronic diseases based on clinical trials.

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Comparative Evaluation of Subgingivally Delivered 2% Curcumin and 0.2% Chlorhexidine Gel Adjunctive to Scaling and Root Planing in Chronic Periodontitis

Cited by 24 publications

References 0 publications

Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and Clinical Applications

Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and Clinical Applications

Oral Microbiome Traits of Type 1 Diabetes and Phenylketonuria Patients in Latvia

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

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