Comparative Evaluation of the Anti-ulcer Activity of Curcumin and Omeprazole during the Acute Phase of Gastric Ulcer—Efficacy of Curcumin in Gastric Ulcer Prevention against Omeprazole

Abstract

ABSTRACT

Development and evaluation of gastroretentive raft forming systems incorporating curcumin-Eudragit® EPO solid dispersions for gastric ulcer treatment

“…That curcumin can prevent and heal gastric ulcers is evident from its dose-dependent effect [5,6]. The curative effect of a curcumin suspension, curcumin raft forming formulation, and lansoprasole on the acetic acid-induced chronic gastric ulcer in rats after 10 days treatment is shown in Table 3.…”

“…Curcumin, a polyphenolic compound from the rhizomes of turmeric (Curcuma longa Linn) has been proven to have biological and pharmacological activities such as being an antioxidant, with anti-inflammatory [2], wound healing [3,4] and anti-peptic ulcer abilities [5,6]. Studies of the efficacy of curcumin on acute and chronic gastric ulcer models in rats have demonstrated that curcumin prevented gastric mucosal lesions in a dose dependent manner and accelerated the healing of chronic gastric ulcer with a similar preventive and curative efficacy to a standard antisecretory agent: omeprazole [5][6][7].…”

“…Studies of the efficacy of curcumin on acute and chronic gastric ulcer models in rats have demonstrated that curcumin prevented gastric mucosal lesions in a dose dependent manner and accelerated the healing of chronic gastric ulcer with a similar preventive and curative efficacy to a standard antisecretory agent: omeprazole [5][6][7]. In terms of safety, there was no toxicity found from the oral administration of curcumin even in a high dose of up to 8,000 mg of curcumin per day for 3 months in humans [8].…”

Role of Curcumin in Disease Prevention and Treatment

“…[ 34 ] Study reported that curcumin and omeprazole showed role in the prevention of gastric lesions development in the gastric wall during the acute phase of gastric ulcer diseases. [ 35 ]…”

Evaluation of antiulcer activity of indole-3-carbinol and/or omeprazole on aspirin-induced gastric ulcer in rats

“…The effects of OMP against gastric mucosal injuries have been thought to depend on its inhibitory action on gastric acid secretion (Kobayashi et al, 2002). However, clinical evaluation of this drug have shown relapse in the long run (Szabo and Vincze, 2000), side effects and drug interactions (Abdul-Aziz, 2011). This has been rational for the development of innovative drug that reduces the offensive factors and is proved to be safe, clinically effective, having better patient tolerance, relatively less expensive and globally competitive.…”