Comparative evaluation of the efficacy of two controlled release devices: Chlorhexidine chips and indigenous curcumin based collagen as local drug delivery systems

Gottumukkala, Sruthima N V S; Sudarshan, Sabitha; Mantena, Satyanarayana Raju

doi:10.4103/0976-237x.132310

Cited by 42 publications

(29 citation statements)

References 25 publications

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“…A comparative study was conducted to measure the therapeutic efficacy of chlorhexidine (CHX) chips and indigenous curcumin‐based collagen as adjuncts to scaling and root planing in the management of chronic periodontitis through nonsurgical procedures. At the end of a 6 month study period, a decrease in plaque and gingival index scores and improved microbiological parameters, probing pocket depth and clinical attachment levels were observed in both CHX chips and curcumin‐based collagen‐treated patients (Gottumukkala et al , ), indicating their beneficial therapeutic effects in the nonsurgical treatment of periodontal disease. Another study carried out by the same group of investigators indicated that 1% curcumin irrigation when used as an adjunct to scaling and root planing had a mild to moderate beneficiary effect (Gottumukkala et al , ).…”

Section: Clinical Studies With Curcuminmentioning

confidence: 98%

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Kunnumakkara

Bordoloi

Padmavathi

et al. 2016

British J Pharmacology

855

601

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Section: Clinical Studies With Curcuminmentioning

confidence: 98%

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Kunnumakkara

Bordoloi

Padmavathi

et al. 2016

British J Pharmacology

855

601

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“…Among the multiple curcumin-formulations [15,21,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129], the phytosomal formulation of CUR (Meriva), which is a complex of curcumin with phosphatidylcholine, is one of the well-studied curcumin-formulation (Table 1). Meriva is prepared by adding phospholipids to the hydroalcoholic extract of turmeric rhizomes under reflux conditions [21].…”

Section: Formulationsmentioning

confidence: 99%

“…Apart from Meriva and Theracurmin, several other CUR formulations have been reported in the literature [117,118,119,120,121,122,123,124,125,126,127,128,129]. Kakkar and Kaur reported a significant reduction in AlCl 3 related neurotoxicity in male lacca mice [117] using a solid lipid nanoparticle CUR formulation [117].…”

Section: Formulationsmentioning

confidence: 99%

“…Similarly, Nayak et al reported curcuminoids loaded nanoparticles, which showed improved antimalarial activity in Albino mice [121]. In a clinical study on 60 periodontitis patients treated with CUR collagen sponge, Gottumukkala et al found a significant reduction in the clinical (plaque and gingival index scores) and microbiological (BANA test and microbial colony count) parameters [129].…”

Section: Formulationsmentioning

confidence: 99%

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Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects

2019

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Turmeric is a curry spice that originated from India, which has attracted great interest in recent decades because it contains bioactive curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin). Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione), a lipophilic polyphenol may work as an anticancer, antibiotic, anti-inflammatory, and anti-aging agent as suggested by several in vitro, in vivo studies and clinical trials. However, poor aqueous solubility, bioavailability, and pharmacokinetic profiles limit curcumin’s therapeutic usage. To address these issues, several curcumin formulations have been developed. However, suboptimal sample preparation and analysis methodologies often hamper the accurate evaluation of bioactivities and their clinical efficacy. This review summarizes recent research on biological, pharmaceutical, and analytical aspects of the curcumin. Various formulation techniques and corresponding clinical trials and in vivo outcomes are discussed. A detailed comparison of different sample preparation (ultrasonic, pressurized liquid extraction, microwave, reflux) and analytical (FT-IR, FT-NIR, FT-Raman, UV, NMR, HPTLC, HPLC, and LC-MS/MS) methodologies used for the extraction and quantification of curcuminoids in different matrices, is presented. Application of optimal sample preparation, chromatographic separation, and detection methodologies will significantly improve the assessment of different formulations and biological activities of curcuminoids.

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“…However, the use of local antimicrobials, inserted directly on the pocket, can reach 100 times the concentration of the same drug administered orally ( Gottumukkala et al, 2014 ). Antimicrobials such as tetracycline, chlorhexidine (CHX), metronidazole ( Bansal et al, 2019 , Singh et al, 2018 ), 10% doxycycline, and 2% minocycline have been used as local drugs in periodontal disease treatment ( Singh et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Use of chlorhexidine chip after scaling and root planning on periodontal disease: A systematic review and meta-analysis

Rosa

Gomes

Moraes

et al. 2021

The Saudi Dental Journal

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Objective This systematic review aims to assess the efficacy chlorhexidine chip as an adjunctive therapy of scaling and root planning on periodontal disease treatment. Material and methods This study follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) and was registered in the PROSPERO database (CRD42019148221). The search was performed in PubMed/MEDLINE, Scopus, and Cochrane databases until April 2020. The PICO question was: “Is the chlorhexidine chip (CHX) effective as an adjunctive therapy of scaling and root planning on periodontal disease treatment?”. Inclusion criteria involved: randomized controlled clinical trials, with a minimum of 15 patients included on the sample and each patient has two sites of probing depth of ≥5 mm; The minimum follow up was at least 1 months of follow-up and the outcomes present in the studies probing depth (PD), plaque index (PI) and clinical attachment level (CAL) after scaling and root planning (SRP). Results After searching the databases, 13 articles were selected for qualitative and 8 for quantitative analysis. Were included 427 patients, with a mean age of 45.6 years. The results shown that the association of chlorhexidine chips to scaling and root planning reduce periodontal pocket depths ( P < 0.00001; MD −0.77 [CI −1.0 to −0.55]; I 2 = 23%, P = 0.24), gain on the clinical attachment level ( P < 0.0001; MD −0.57 [CI −0.86 to −0.27]; I 2 = 33%, P = 0.18P < 0.0001) and reduction on plaque index (P = 0.04; MD −0.23 [CI −0.45 to −0.01]; I 2 = 91%, P < 0.00001). Conclusions Thus, we can conclude that chlorhexidine chip when used associated to scaling and root planning promoted a significant improvement the reduction of periodontal diseases.

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Comparative evaluation of the efficacy of two controlled release devices: Chlorhexidine chips and indigenous curcumin based collagen as local drug delivery systems

Cited by 42 publications

References 25 publications

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects

Use of chlorhexidine chip after scaling and root planning on periodontal disease: A systematic review and meta-analysis

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