Comparative Evaluation of the Photostability of Carbamazepine Polymorphs and Cocrystals

Yutani, Reiko; Haku, Ryotaro; Teraoka, Reiko; Tode, Chisato; Koide, Tatsuo; Kitagawa, Shuji; Sakane, Toshiyasu; Fukami, Toshiro

doi:10.3390/cryst9110553

Cited by 11 publications

(3 citation statements)

References 31 publications

(46 reference statements)

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“…(1) ). However, a qualitative observation of the overall shape of experimental and RK-calculated traces of such photoreactions indicates that they do not seem to substantially differ from those recorded for reactions subjected to monochromatic light ( Lente and Espenson, 2004 ; Fabian and Lente, 2010 ; Roibu et al, 2018 ; Volfova et al, 2019 ; Yutani et al, 2019 ; Maafi and Al Qarni, 2022a ; Maafi and Al Qarni, 2022b ; Weingartz et al, 2023 ). This observation allows one to conjecture that the kinetics under polychromatic light may well be of

-order character, similar to that previously established for the photokinetics of systems exposed to monochromatic light ( Maafi, 2023 ).…”

Section: Resultsmentioning

confidence: 82%

On photokinetics under polychromatic light

Maafi

2024

Front. Chem.

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Since the dawn of photochemistry 150 years ago, photoreactions have been conducted under polychromatic light. However, despite the pivotal role that photokinetics should naturally play for such reactive photosystems, the literature lacks a comprehensive description of that area. Indeed, one fails to identify explicit model integrated rate laws for these reactions, a characteristic type for their kinetic behavior, or their kinetic order. In addition, there is no consensus in the community on standardized investigative tools to evaluate the reactivity of these photosystems, nor are there venues for the discussion of such photokinetic issues. The present work is a contribution addressing some of these knowledge gaps. It proposes an unprecedented general formula capable of mapping out the kinetic traces of photoreactions under polychromatic light irradiation. This article quantitatively discusses several reaction situations, including the effects of initial reactant concentration and the presence of spectator molecules. It also develops a methodology for standardizing actinometers and defines and describes both the spectral range of highest reactivity and the photonic yield. The validity of the model equation has been proven by comparing its results to both theoretical counterparts and those generated by fourth-order Runge–Kutta numerical calculations. For the first time, a confirmation of the Φ-order character of the kinetics under polychromatic light was established.

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-order character, similar to that previously established for the photokinetics of systems exposed to monochromatic light ( Maafi, 2023 ).…”

Section: Resultsmentioning

confidence: 82%

On photokinetics under polychromatic light

Maafi

2024

Front. Chem.

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“…CBZ-NIC and CBZ-SAC co-crystals were prepared by the slow solvent evaporation method according to a previously reported method [22], as shown in Figure 1a. Equimolar APIs (CBZ, 236 mg, 1 mmol) and CFFs (NIC, 122 mg, 1 mmol or SAC, 183 mg, 1 mmol) were dissolved in an amount of ethanol (40 mL) and stirred for 3 h. The solution was slowly evaporated at room temperature and then co-crystals were obtained after several days.…”

Section: Methodsmentioning

confidence: 99%

Low-Frequency Vibrational Spectroscopy Characteristic of Pharmaceutical Carbamazepine Co-Crystals with Nicotinamide and Saccharin

Wang

Zhu³

et al. 2022

Sensors

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The pharmaceutical co-crystal has attracted increasing interest due to the improvement of physicochemical properties of active pharmaceutical ingredients. The characterization of pharmaceutical co-crystal is an integral part of the pharmaceutical field. In this paper, the low-frequency vibrational properties for carbamazepine co-crystals with nicotinamide and saccharin (CBZ-NIC and CBZ-SAC) have been characterized by combining the THz spectroscopy with low-wavenumber Raman spectroscopy. The experiment results show that, compared with the individual constituents, CBZ-NIC and CBZ-SAC co-crystals not only have different characteristic absorption peaks in the 0.3-2.5 THz region, but also have significant low-wavenumber Raman characteristic peaks in 0–100 cm−1. Density functional theory was performed to simulate the terahertz and low-wavenumber Raman spectra of the two co-crystals, where the calculation agreed well with the measured vibrational peak positions. The vibrational modes of CBZ-NIC and CBZ-SAC co-crystals were assigned through comparing theoretical results with the experimental spectra. Meanwhile, the low-frequency infrared and/or Raman active of characteristic peaks for such co-crystals were discussed. The results indicate the combination of THz spectroscopy and low-wavenumber Raman spectroscopy can provide more comprehensive low-frequency vibrational information for pharmaceutical co-crystals, such as collective vibration and skeleton vibration, which could play an important role in pharmaceutical science.

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“…Zhang et al [2] found a novel co-crystal of the potent H2 receptor antagonist famotidine (FMT) with masonic acid, which was stable, and showed higher solubility than the intact crystalline phase. Another essential property of photostability was evaluated in carbamazepine polymorphs (forms I to III) and three co-crystals [3]. Yutani et al fully utilized FT-IR, low-frequency Raman spectroscopy, and solid-state NMR to find that lower molecular mobility is the key to higher photostability.…”

Section: Dear Colleaguesmentioning

confidence: 99%