Comparative evaluation of the powder properties and compression behaviour of a new cellulose-based direct compression excipient and Avicel PH-102

Abstract

This study compares the compression behaviour of a new cellulose-based tableting excipient, hereinafter referred to as UICEL-A/102, and Avicel PH-102, a commercial direct compression excipient commonly referred to as microcrystalline cellulose (MCC). UICEL-A/102 shows the cellulose II lattice, while Avicel PH-102 belongs to the cellulose I polymorphic form. The median particle diameters of UICEL-A/102 and Avicel PH-102 fractions used in the study were 107 and 97 microm, respectively. Compared with Avicel PH-102, UICEL-A/102 was more dense; the relative poured and tapped densities were: 0.277 and 0.327 (vs 0.195 and 0.248 for Avicel PH-102), respectively. The true density, rhotrue, of the two materials was comparable ( approximately 1.56 g cm(-3)). The slopes of the in-die and out-of-die Heckel curves for Avicel PH-102 were steeper than for UICEL-A/102. The relative density versus applied pressure plot was in good agreement with the modified Heckel equation. The out-of-die and in-die minimal pressure susceptibility (chipmin) values calculated were 3.36 x 10(-3) and 8.09 x 10(-3) MPa(-1) for UICEL-A/102 and 8.00 x 10(-3) and 16.12 x 10(-3) MPa(-1) for Avicel PH-102, respectively. The elastic recovery profiles showed UICEL-A/102 to be more elastic than Avicel PH-102. In conclusion, UICEL-A/102 and Avicel PH-102 differ in their compression behaviour under pressure. The different polymorphic forms could provide a possible explanation.

Development of directly compressible excipients from phoenix dactylifera (date) mucilage and microcrystalline cellulose using co-processing techniques

“…The bulk density of the excipients was determined by weighing 10 g of the sample and transferring it at an angle of 45° through a funnel into a 100 mL glass measuring cylinder with a diameter of 3.0 cm The height reached by the powder was recorded and the volume and density were then calculated The method of Reus-Medina 23 was used in evaluating the tapped volume and density using a weighed quantity (10 g) of the excipients. Tapping rate was standardized with 38 taps per minute and a total of 250 taps was applied to the material in a graduated glass cylinder.…”

Characterization of cucumis sativus (linnaeus) mucilage and its excipient potentials in metronidazole tablet formulation

“…The density was calculated from the ratio of the mass to the volume. The tapped volume was measured by applying 100 taps to 30 g of CSM or granules in a graduated glass cylinder at a standardized rate of 38 taps per min 9 . The particle density was measured using a 50 mL liquid pycnometer bottle with xylene as the displacement fluid 10 .…”

“MCC SANAQ®burst”—A New Type of Cellulose and its Suitability to Prepare Fast Disintegrating Pellets

“…Cellulose I as powder cellulose and MCC I are widely used in pharmaceutical products for many years. Recently, cellulose II was introduced by Kumar as pharmaceutical excipient in direct tableting process [7,8]. A comparison with MCC I as one of the most useful filler for direct compression discovered not only differences in the compression behavior, but also remarkable differences for disintegration: for cellulose IIbased tablets, a shorter disintegration time that appeared to be independent of the relative density of the tablet could be observed [9].…”