Comparative evaluation of the sexual functions and NF-κB and Nrf2 pathways of some aphrodisiac herbal extracts in male rats

Şahin, Kazım; Orhan, Cemal; Akdemir, Fatih; Tuzcu, Mehmet; Gençoğlu, Hasan; Şahin, Nurhan; Türk, Gaffari; Yılmaz, İsmet; Ozercan, İbrahim Hanifi; Juturu, Vijaya

doi:10.1186/s12906-016-1303-x

Cited by 51 publications

(40 citation statements)

References 45 publications

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“…The results indicated that the extract of TT was comparatively more potent than the two others. These herbs are potent enhancers of sexual function and behaviour by increasing the testosterone levels and regulating the NF-κB and Nrf2/HO–1 pathways in male rats [53]. …”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Zhu

Meng

et al. 2017

Chemistry Central Journal

133

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Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance in men. The fruits and roots of TT have been used as a folk medicine for thousands of years in China, India, Sudan, and Pakistan. Numerous bioactive phytochemicals, such as saponins and flavonoids, have been isolated and identified from TT that are responsible alone or in combination for various pharmacological activities. This review provides a comprehensive overview of the traditional applications, phytochemistry, pharmacology and overuse of TT and provides evidence for better medicinal usage of TT.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Zhu

Meng

et al. 2017

Chemistry Central Journal

133

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“…ROS is the main cause of oxidative stress, which is thought to be an important and reasonable cause of idiopathic male infertility and sexual dysfunction, and oxidative stress-induced sperm DNA damage negatively affects the reproductive outcome [ 12 ]. In a previous study where we used Tribulus , Ashwagandha, and Mucuna separately in rats, we determined that their extracts may be potent enhancers for sexual function and behavior via increasing testosterone levels and regulation of NF- κ B and Nrf2/HO-1 pathway with a concomitant decrease in ROS levels as well [ 13 ]. Despite the fact that the small amount of ROS is required for healthy sperm functioning, excessive exposure to ROS levels can adversely affect spermatozoa quality and weaken overall fertilization capacity as well [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Aphrodisiac-effective many plants and their extracts such as Epimedii herba (horny goat weed), Lepidium meyenii (Maca), Mucuna pruriens, Panax ginseng, Tribulus terrestris, and Withania somnifera (Ashwagandha) have been reported in the literature to increase sperm number, sexual strength, and testosterone levels while mostly lowering the detriments caused by oxidative stress in the metabolism as well when used at appropriate doses [ 13 , 21 ]. Thus, Mucuna pruriens , Tribulus terrestris , and Ashwagandha are aphrodisiac plants used for centuries in traditional Indian and Chinese medicine, which was shown to improve penile erection, develop sperm quality, enhance sexual behaviors, and increase androgen hormone levels in several studies [ 22 – 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, Mucuna pruriens , Tribulus terrestris , and Ashwagandha are aphrodisiac plants used for centuries in traditional Indian and Chinese medicine, which was shown to improve penile erection, develop sperm quality, enhance sexual behaviors, and increase androgen hormone levels in several studies [ 22 – 26 ]. Although there have been many studies on the separate use of Mucuna pruriens , Tribulus terrestris , and Ashwagandha in the field of male infertility and erectile disorders [ 13 , 22 – 26 ], no studies have been found on the combined use of these herbs. In particular, the underlying molecular mechanisms through which combination of these extracts improves above parameters are still unclear.…”

Section: Introductionmentioning

confidence: 99%

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MAT, a Novel Polyherbal Aphrodisiac Formulation, Enhances Sexual Function and Nrf2/HO‐1 Pathway While Reducing Oxidative Damage in Male Rats

Şahin

Tuzcu

Orhan

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Mucuna pruriens, Ashwagandha, and Tribulus terrestris are known as the enhancers for sexual health, functional activities, vitality, and longevity. These herbs had been widely used in the Ayurveda medicine as aphrodisiacs through the ages, and their efficacy was also verified separately in our previous publication. Therefore, the aim of this study was to determine the effects of Mucuna, Ashwagandha, and Tribulus complexes on sexual function in rats. Twenty-eight male rats allocated to four groups as follows: (i) negative control (C); (ii) positive control or sildenafil citrate treated group (5 mg/kg) (S); (iii) MAT1 (combination of 10 mg Mucuna (M) + 10 mg Ashwagandha (A) + 10 mg Tribulus (T)/kg BW); (iv) MAT 2 (20 mg Mucuna + 20 mg Ashwagandha + 20 mg Tribulus/kg BW). There was no significant difference found between the MAT1 and MAT2 groups while they showed significantly increased testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels when compared to the negative control. Significant increases in Nrf2/HO1 levels and decreases in NF-κB were detected in MAT groups similar to the decrease in serum and testis malondialdehyde (MDA) levels as compared to both controls. The sperm motility, count, and rate also significantly improved in both MAT groups, while ALT, AST, creatinine, ALP, and urea levels did not change in any of the groups. Oral consumption of MATs combination in male rats resulted in inhibition of NF-κB and MDA and also increased sex hormones with Nrf2-mediated HO-1 induction. MAT combinations may improve sexual functions by increasing levels of sexual hormones and regulation of NF-κB and Nrf2/HO-1 signaling pathways.

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“…Reproducibility and device/method sensitivity of LABGEOPT10 were established according to IVR-PT06 guidelines. Serum and liver MDA levels were measured using the method described by Sahin et al (16). Malondialdehyde (MDA) levels were measured using the fully automatic high-performance liquid chromatography (Shimadzu, Kyoto, Japan) equipped with a pump (LC-20 AD), an ultraviolet-visible detector (SPD-20A), an inertsil ODS-3 C18 column (250 × 4.6 mm, 5 m), a column oven (CTO-10ASVP), an autosampler (SIL-20A), a degasser unit (DGU-20A5) and a computer system with LC solution Software (Shimadzu) (16).…”

Section: Laboratory Analysismentioning

confidence: 99%

Hepatoprotective effects of Tribulus terrestris, Ashwagandha and N-acetylcysteine on liver fibrosis in carbon tetrachloride-induced rats

Altay¹,

Doğan²,

Orhan³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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Fibrosis, which develops during the progression of liver damage, is the previous stage of cirrhosis. Carbon tetrachloride is one of the most commonly used hepatic toxins in experimental animal models of liver fibrosis. It was investigated the hepatoprotective effects of Tribulus terrestris, Ashwagandha and N-acetylcysteine in an experimental model of liver fibrosis induced by carbon tetrachloride in this study. Fifty Wistar rats were divided into five groups of 10 each, as follows: 1) Control, 2) Carbon tetrachloride, 3) Carbon tetrachloride plus N-acetylcysteine, 4) Carbon tetrachloride plus T. terrestris, and 5) Carbon tetrachloride plus Ashwagandha group. At the end of 6 weeks, the rats were sacrificed, and serum and tissue samples were collected. Aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, malondialdehyde, NF-κB, collagen 1, nuclear factor erythroid-2-related factor 2, tumor necrosis factor-α were analyzed, and histopathological evaluation was performed. There were no significant differences in serum aspartate aminotransferase and alanine aminotransferase levels of the N-acetylcysteine-treated group versus those in the T. terrestris-and Ashwagandha-treated groups (p > 0.05). Liver malondialdehyde levels were lower in the Nacetylcysteine-, T. terrestris-and Ashwagandha-treated groups than in the carbon tetrachloride-administered group (p < 0.001). There were differences between groups in NF-κB, collagen 1, nuclear factor erythroid-2related factor 2 and tumor necrosis factor-α levels (p < 0.05). In conclusion, T. terrestris, Ashwagandha and Nacetylcysteine had protective effects on the liver in this experimental fibrosis model. T. terrestris was a little more effective than Ashwagandha in combating liver fibrosis.

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Comparative evaluation of the sexual functions and NF-κB and Nrf2 pathways of some aphrodisiac herbal extracts in male rats

Cited by 51 publications

References 45 publications

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

MAT, a Novel Polyherbal Aphrodisiac Formulation, Enhances Sexual Function and Nrf2/HO‐1 Pathway While Reducing Oxidative Damage in Male Rats

Hepatoprotective effects of Tribulus terrestris, Ashwagandha and N-acetylcysteine on liver fibrosis in carbon tetrachloride-induced rats

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