Comparative Evaluation of Trace Metals in the Blood of Hepatitis C Patients and Healthy Donors

Saghir, M. Abdullah; Shaheen, N.; Shah, Munir H.

doi:10.1007/s12011-010-8930-8

Cited by 8 publications

(11 citation statements)

References 28 publications

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“…There is an absence of detailed knowledge regarding the kinetics of Mn removal from the body, particularly the brain. It is unknown whether subclinical hepatic effects of chronic hepatitis C infection can influence the accumulation of Mn by the body; indeed slightly reduced blood Mn levels have been noted in chronic hepatitis C carriers .…”

Section: Discussionmentioning

confidence: 99%

The outcome of the movement disorder in methcathinone abusers: clinical,MRIand manganesemia changes, and neuropathology

Stepens

Groma

Skuja

et al. 2013

Euro J of Neurology

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No improvement in this Mn-induced movement disorder occurs after cessation of methcathinone abuse despite improvement of Mn blood levels and/or MRI abnormalities. Ultrastructural abnormalities in a former user confirm structural damage to white matter is associated with the disorder. Methcathinone/Mn toxicity is an important, disabling and permanent medical sequel of intravenous drug abuse in the former Soviet Union.

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Section: Discussionmentioning

confidence: 99%

The outcome of the movement disorder in methcathinone abusers: clinical,MRIand manganesemia changes, and neuropathology

Stepens

Groma

Skuja

et al. 2013

Euro J of Neurology

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“…Most of the relevant publications are concerned with the relationship between the content of microelements in the body and the incidence of cancer [ 8 , 11 – 13 ]. Other diseases, such as cardiovascular disease [ 9 ] and hepatitis C [ 10 ] have also been considered in this context.…”

Section: Introductionmentioning

confidence: 99%

Essential and Toxic Metals in Oral Fluid–a Potential Role in the Diagnosis of Periodontal Diseases

Herman

Golasik

Piekoszewski

et al. 2016

Biol Trace Elem Res

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Recently, many studies have investigated the relationship between the level of metals in the body and various diseases. The objective of this study was to examine any possible influence of periodontal disease upon the concentration of metals in oral fluid and blood and to explore the usability of applying cluster analysis coupled with the analysis of selected elements in oral fluid, calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), zinc (Zn), cadmium (Cd) and lead (Pb), for effectively distinguishing people affected by periodontitis from healthy individuals. The quantification of eight metals in oral fluid and blood samples was performed by two inductively coupled plasma techniques–inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES). Most of the examined elements were detected at elevated concentration in the oral fluid of periodontal patients. However, the differences were statistically significant in the case of three metals: Cu, Mg and Mn (p < 0.05). Approximately, fivefold increase in the concentration of Cu, threefold-elevated levels of Mn and a twofold increase in the concentration of Mg were found in the oral fluid of the periodontal patients compared to the controls. Cluster analysis confirmed the statistical significance of the differences in the level of metals in the oral fluid between the two groups in most cases, plus enabled the correct classification of the subjects into patients and controls. The relationship between concentrations of metals and periodontal disease may in the future serve to prevent the development of such disease.

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“…Numerous environmental monitoring programmes related to the distribution, absorption, kinetics and deleterious effects of toxic elements in biological systems have been carried out 8 . Blood, breast milk, urine, foetal membranes, hair, placenta, saliva and nails are often used as complementary diagnostic tissue for measuring trace elements and each tissue provides unique clinical information about elemental levels of exposed individuals 9,10 . Furthermore, analyses of blood and hair have been linked with future development of diseases thus manifesting their potential as predictive and preventive markers in addition to monitor the current status and symptoms of elemental imbalances.…”

Section: Introductionmentioning

confidence: 99%

Disparities in the Concentrations of Essential/Toxic Elements in the Blood and Scalp Hair of Lymphoma Patients and Healthy Subjects

Qayyum

Shah

2019

Sci Rep

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Lymphoma is one of the fastest growing malignancies worldwide and imbalance in the concentrations of trace elements can play a significant role in the onset and progression of the disease. Selected essential and toxic elements (Fe, Zn, Cu, Mn, Ni, Cr, Cd and Pb) were analysed in the blood & scalp hair of lymphoma patients (n = 59 & 58, respectively) and controls (n = 61 & 60, respectively) by atomic absorption spectrometry. On the average, Ni, Cr, Cu and Cd revealed significantly higher contents in the blood and scalp hair of the patients than the controls (p < 0.05). The correlation study showed significantly diverse relationships among the elements in blood & scalp hair of the two donor groups. Variations in the elemental levels with different types of lymphoma (non-Hodgkin and Hodgkin) were also evaluated. Disparities in the elemental concentrations were also investigated for various types of non-Hodgkin (diffuse large B-cell lymphoma, follicular lymphoma and peripheral T-cell lymphoma) and Hodgkin lymphoma (mixed cellularity, nodular lymphocyte predominant and nodular sclerosing), as well as for different stages (I, II, III & IV) of the cancer. Multivariate statistical analysis showed considerably divergent associations of the elements in the patients and controls. The study indicated profound alteration of the elemental levels in the patients; it may be implicated in elemental-induced disorders including lymphoma.

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Comparative Evaluation of Trace Metals in the Blood of Hepatitis C Patients and Healthy Donors

Cited by 8 publications

References 28 publications

The outcome of the movement disorder in methcathinone abusers: clinical,MRIand manganesemia changes, and neuropathology

The outcome of the movement disorder in methcathinone abusers: clinical,MRIand manganesemia changes, and neuropathology

Essential and Toxic Metals in Oral Fluid–a Potential Role in the Diagnosis of Periodontal Diseases

Disparities in the Concentrations of Essential/Toxic Elements in the Blood and Scalp Hair of Lymphoma Patients and Healthy Subjects

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