“…During this period, great efforts have been made to realize an effective analgesia system combined with the noninvasive technique, such as Han's acupoint nerve stimulator (HANS) [13], the 64-independent channel stimulator (ShefStim-SBS) [14], and the transcutaneous electrical nerve stimulator (DX66053) [15]. These devices are based on TENS and have shown significant efficacy in controlling postoperative pain after various procedures, including cardiac surgeries [16], cholecystectomy [17], cesarean section [18], liposuction [19], total knee arthroplasty [20], and thoracotomy [21]. The analgesic effects of TENS are reportedly produced via the activation of opioid receptors [22], [23], [24], descending pain modulation, and segmental pain inhibition [25].…”