Comparative evaluation of treatment patterns and healthcare utilization of newly-diagnosed rheumatoid arthritis patients by anti-cyclic citrullinated peptide antibody status

Abstract

RA patients with positive anti-CCP antibodies had higher degrees of inflammation and disease activity as indicated by laboratory results, which likely contributed to their higher rates of healthcare utilization, joint erosion, and proportions of RA treatment.

Immunogenicity and persistence of a prime-boost re-vaccination strategy for pneumococcal vaccines in patients with rheumatoid arthritis

“…Thus, the association of poor vaccine response in patients positive for anti-CCP may be related to the less immunogenicity of the vaccine in the more severe and agressive forme of RA. 33,34 To our knowledge, this is the first study describing the long-term evolution of the anti-polysaccharides antibody response after pneumococcal vaccination especially in the case of a prime boost strategy. If the percentage of protection is quite equivalent for the seven common and the three uncommon serotype, the more intense drop in antibody response for the seven common serotype compared to the three uncommon may suggest a negative impact of the PPV23 vaccine on the PCV13 response.…”