Comparative genome analysis of Corynebacterium species: The underestimated pathogens with high virulence potential

Nasim, Fouzia; Dey, Arijit; Qureshi, Insaf Ahmed

doi:10.1016/j.meegid.2021.104928

Cited by 19 publications

(7 citation statements)

References 42 publications

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“…In general, an open pangenome is predominant in bacteria that are susceptible to horizontal gene transfer (HGT) ( 29 ). Based on the power-law regression model used in this study, similar results were determined in the species Enterococcus faecalis ( 30 ) and Acinetobacter baumannii ( 31 ) and the genera Metallosphaera ( 32 ) and Corynebacterium ( 33 ).…”

Section: Resultssupporting

confidence: 61%

Comparative Genomics Reveals Genetic Diversity and Metabolic Potentials of the Genus Qipengyuania and Suggests Fifteen Novel Species

Liu

Pei

et al. 2022

Microbiol Spectr

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The deciphering of the phylogenetic diversity and metabolic features of the abundant bacterial taxa is critical for exploring their ecological importance and application potential. Qipengyuania is a genus of frequently isolated heterotrophic microorganisms with great industrial application potential. Numerous strains related to the genus Qipengyuania have been isolated from diverse environments, but their genomic diversity and metabolic functions remain unclear.

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Section: Resultssupporting

confidence: 61%

Comparative Genomics Reveals Genetic Diversity and Metabolic Potentials of the Genus Qipengyuania and Suggests Fifteen Novel Species

Liu

Pei

et al. 2022

Microbiol Spectr

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“…Among which, Corynebacterium has been traced to the cause of several infectious diseases in either immunocompetent or immunocompromised hosts. 60 Coriobacteriaceae has been proved to be positively associated with fecal reactive oxygen species (ROS) formation to induce inflammation. 61 These specific bacteria detected in the model group suggested the disturbance of intestinal flora by overdose PCM induction.…”

Section: Resultsmentioning

confidence: 99%

Integration of intestinal microbiota and metabonomics to elucidate different alleviation impacts of non-saponification and saponification astaxanthin pre-treatment on paracetamol-induced oxidative stress in rats

Song

Jia

et al. 2022

Food Funct.

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“…glutamicum pan-genome, which indicates that new gene families continuously will be added to the pan-genome. The open pan-genome of Corynebacterium at genus level was also reported by the pan-genomic analysis of 40 strains of eleven different Corynebacterium species [ 76 ]. Thus, the pan-genome of C .…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of genomic variation, pan-genome and biosynthetic potential of Corynebacterium glutamicum strains

Rahman,

Shimul,

Parvez

2024

PLoS ONE

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Corynebacterium glutamicum is a non-pathogenic species of the Corynebacteriaceae family. It has been broadly used in industrial biotechnology for the production of valuable products. Though it is widely accepted at the industrial level, knowledge about the genomic diversity of the strains is limited. Here, we investigated the comparative genomic features of the strains and pan-genomic characteristics. We also observed phylogenetic relationships among the strains based on average nucleotide identity (ANI). We found diversity between strains at the genomic and pan-genomic levels. Less than one-third of the C. glutamicum pan-genome consists of core genes and soft-core genes. Whereas, a large number of strain-specific genes covered about half of the total pan-genome. Besides, C. glutamicum pan-genome is open and expanding, which indicates the possible addition of new gene families to the pan-genome. We also investigated the distribution of biosynthetic gene clusters (BGCs) among the strains. We discovered slight variations of BGCs at the strain level. Several BGCs with the potential to express novel bioactive secondary metabolites have been identified. Therefore, by utilizing the characteristic advantages of C. glutamicum, different strains can be potential applicants for natural drug discovery.

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Comparative genome analysis of Corynebacterium species: The underestimated pathogens with high virulence potential

Cited by 19 publications

References 42 publications

Comparative Genomics Reveals Genetic Diversity and Metabolic Potentials of the Genus Qipengyuania and Suggests Fifteen Novel Species

Comparative Genomics Reveals Genetic Diversity and Metabolic Potentials of the Genus Qipengyuania and Suggests Fifteen Novel Species

Integration of intestinal microbiota and metabonomics to elucidate different alleviation impacts of non-saponification and saponification astaxanthin pre-treatment on paracetamol-induced oxidative stress in rats

Comprehensive analysis of genomic variation, pan-genome and biosynthetic potential of Corynebacterium glutamicum strains

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