Comparative Genomic Analysis Provides Insights into the Phylogeny, Resistome, Virulome, and Host Adaptation in the Genus Ewingella

Liu, Zhenghui; Sheng, Hongyan; Okorley, Benjamin Azu; Liu, Yu; Sossah, Frederick Leo

doi:10.3390/pathogens9050330

Cited by 11 publications

(13 citation statements)

References 115 publications

(127 reference statements)

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“…Our case is notable not only for the unique organism but for its incredibly multidrug-resistant nature (Table 4). Also, based on the recommendations of the Clinical and Laboratory Standards Institute, they concluded that E. americana is resistant to many antibiotics (Table 5) [9]. It was found that E. americana contains about 67 putative virulence genes [9].…”

Section: Discussionmentioning

confidence: 99%

“…Also, based on the recommendations of the Clinical and Laboratory Standards Institute, they concluded that E. americana is resistant to many antibiotics (Table 5) [9]. It was found that E. americana contains about 67 putative virulence genes [9]. The virulence features include the secretion system, adherence, invasion, chemotaxis, motility, immune evasion, and pore-forming toxins [9].…”

Section: Discussionmentioning

confidence: 99%

“…It was found that E. americana contains about 67 putative virulence genes [9]. The virulence features include the secretion system, adherence, invasion, chemotaxis, motility, immune evasion, and pore-forming toxins [9]. These features can be the reason for the multidrug-resistant nature of E. americana.…”

Section: Discussionmentioning

confidence: 99%

“…Enterococcus faecalis (E. faecalis) demonstrating low colony counts (Tables 3, 4). testing was done using E. coli as a control to detect antibiotic resistance in Ewingella (Table 5) [9]. The penile culture was positive for extended-spectrum beta-lactamase (ESBL) producing Klebsiella Pneumonia and E. faecalis (Tables 5, 6).…”

Section: Urinalysis (Foley)mentioning

confidence: 99%

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The First Known Documented Case of Ewingella Americana Urinary Tract Infection

Hourizadeh¹,

Joy²,

Berger³

et al. 2023

Cureus

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We present a 73-year-old male with a history of end-stage renal disease (ESRD) on dialysis, type 2 diabetes mellitus, coronary artery disease status post stents, prostate carcinoma status post radiation, and prostatectomy, with recurrent bladder neck contracture requiring suprapubic catheter, left urethral stricture with nephrostomy tube placement, penile implant, and recurrent urinary tract infections, who presented to the emergency room complaining of constant bilateral groin pain for one day. Physical exam was significant for suprapubic tenderness and a chronic suprapubic catheter and left-sided nephrostomy tube. An initial examination of the patient's urine revealed turbid, yellow-colored fluid, positive for white blood cells, leukocyte esterase, and bacteria. A urine culture was obtained, which returned positive for E. americana, with >100,000 colony-forming units (CFUs) as well as Enterococcus faecalis (E. faecalis) demonstrating low colony counts. The patient was treated with a seven-day course of meropenem 1 gm twice daily, which improved of his symptoms, and then completed a 10-day course of ertapenem 500 mg daily. The patient received a five-day course of vancomycin 1 gm on dialysis days for additional coverage of E. faecalis, despite low colony counts. This is the first documented case of a urinary tract infection caused by E. americana. The organism is primarily found in immunocompromised individuals, and a debate is still ongoing as to whether it is a true pathogen or exists primarily as an opportunistic infection. We suggest further inquiry and study of this resistant organism are paramount in establishing its role in both immunocompromised as well as immunocompetent individuals. E. americana is a multidrug-resistant organism, which to date has sparse documentation regarding its prevalence and potential for morbidity, especially in compromised individuals. In the era of increasing antibiotic resistance, we suggest that more research is needed to understand the pathogenicity of E. americana.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Urinalysis (Foley)mentioning

confidence: 99%

See 2 more Smart Citations

The First Known Documented Case of Ewingella Americana Urinary Tract Infection

Hourizadeh¹,

Joy²,

Berger³

et al. 2023

Cureus

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“…1a and S1) originating from essentially any environments like soil, plants, higher eukaryotes including mammals, or the marine environment. [4,5,[13][14][15] In general, ape BGCs consist of genes encoding unusual type II polyketide synthases (PKSs), enzymes involved in lipid biosynthesis, and membrane proteins for localization ( Fig. 1b).…”

Section: Introductionmentioning

confidence: 99%

The Chemical Structure of Widespread Microbial Aryl Polyene Lipids

Grammbitter

Shi

et al. 2020

Preprint

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Biosynthetic gene clusters (BGC) involved in aryl polyene (APE) biosynthesis are supposed to represent the most widespread BGC in the bacterial world.[1–3] Still, only hydrolysis products[4–8] and not the full-length product(s) have been identified, hindering studies on their biosynthesis and natural function. Here, we apply subsequent chromatographic separations to purify the aryl polyene-containing lipids (APELs) from the entomopathogenic bacterium Xenorhabdus doucetiae. Structure elucidation using a combination of isotope labeling, nuclear magnetic resonance techniques, and tandem mass spectrometry reveals an array of APELs featuring an all-trans C26:5 conjugated fatty acyl and a galactosamine-phosphate-glycerol moiety. In combination with extensive genetic studies, this research broadens the bacterial natural product repertoire and paves the way for future functional characterization of this almost universal microbial compound class. Due to their protective function against reactive oxygen species,[5,9] APELs might be important for virulence or symbiosis, mediating organismic interactions in several ecological niches.

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Yersiniaceae

Kingry,

Gladney,

Petersen

2023

ClinMicroNow

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The family Yersiniaceae includes two well‐known pathogenic genera, Serratia and Yersinia , and multiple other genera which inhabit a wide range of ecological niches. Serratia marcescens is the Serratia species most often isolated from clinical specimens and can cause urinary tract infections, pneumonia, bloodstream infections, endocarditis, and wound infections. This chapter primarily focuses on the taxonomy, detection, and identification of Serratia and Yersinia . Yersiniaceae members are Gram‐negative rods that are non‐spore‐forming, oxidase‐negative, catalase‐positive facultative anaerobes which display nonfastidious growth. The Yersiniaceae are widely distributed throughout the environment and transmitted to humans via arthropod bites, contact with infected animals, ingestion of contaminated food or water, or exposure to hospital environments and medical procedures. Serology can be used as an adjunct in the diagnosis of disease due to Yersinia enterocolitica or Yersinia pseudotuberculosis . Many S. marcescens strains carry both chromosomally encoded and plasmid‐mediated resistance determinants for several different types of antimicrobials.

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Comparative Genomic Analysis Provides Insights into the Phylogeny, Resistome, Virulome, and Host Adaptation in the Genus Ewingella

Cited by 11 publications

References 115 publications

The First Known Documented Case of Ewingella Americana Urinary Tract Infection

The First Known Documented Case of Ewingella Americana Urinary Tract Infection

The Chemical Structure of Widespread Microbial Aryl Polyene Lipids

Yersiniaceae

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