Comparative Genomic Analysis Reveals Genetic Diversity and Pathogenic Potential of Haemophilus seminalis and Emended Description of Haemophilus seminalis

Chen, Xiao Wei; Zhang, Hanyun; Feng, Jun-Hui; Zhang, Lei; Zheng, Minling; Luo, Haimin; Zhuo, Huiyan; Xu, Ning; Zhou, Xuan; Cha, Chen; Qu, Pinghua; Li, Youqiang

doi:10.1128/spectrum.04772-22

Cited by 4 publications

(1 citation statement)

References 73 publications

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“…The species is related to H. haemolyticus (Figure 1). Comparative genomic analyses have recently identified H. seminalis cultured from other locations, including urine and cerebrospinal fluid [33]. However, it is unlikely that strains of H. seminalis were previously misidentified as H. influenzae, as the functional heme biosynthesis pathway present in H. seminalis provides independence of hemin (X-factor), which is a classical phenotypic trait of H. parainfluenzae.…”

Section: Discussionmentioning

confidence: 99%

Genome Characterisation of Invasive Haemophilus influenzae in Pregnancy: The Noticeable Placental Tissue Tropism Is Distributed across the Species Rather Than Linked with Capsulation or Particular Clones

Nørskov-Lauritsen,

Mohey,

Hansen

et al. 2023

Pathogens

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Pregnancy is associated with a 5–26 times increased risk of invasive Haemophilus influenzae infection and subsequent adverse pregnancy outcomes. Incidence rate and outcome are published in some regions, but the characterisation of bacterial isolates is limited. We performed comparative genomic analyses of isolates from 12 pregnancy-associated cases, cultured from maternal bacteraemia in pregnancy (nine), postpartum bacteraemia (one), neonatal bacteraemia (one), and placental tissue (one). In two bacteraemia cases, identical isolates were also cultured from cervical swabs. Eight cases occurred early in pregnancy (gestational week 7–26), and seven of them resulted in miscarriage or neonatal death. All bacterial genomes were devoid of capsule loci, and they were evenly distributed in the major phylogenetic group I of the species. The conspicuous tropism of H. influenzae for pregnancy and placental tissue is associated with the species rather than specific clonal subtypes.

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Section: Discussionmentioning

confidence: 99%

Genome Characterisation of Invasive Haemophilus influenzae in Pregnancy: The Noticeable Placental Tissue Tropism Is Distributed across the Species Rather Than Linked with Capsulation or Particular Clones

Nørskov-Lauritsen,

Mohey,

Hansen

et al. 2023

Pathogens

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Comparative genomic study of non-typeable Haemophilus influenzae in children with pneumonia and healthy controls

Zhang,

Wang,

Song

et al. 2024

iScience

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Introgression impacts the evolution of bacteria, but species borders are rarely fuzzy

Diop,

Bobay

2024

Preprint

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Most bacteria engage in gene flow and that this may act as a force maintaining species cohesiveness like it does in sexual organisms. However, introgression (gene flow between the genomic backbone of distinct species) has been reported in bacteria and is associated with fuzzy species borders in some lineages, but its prevalence and impact on the delimitation of bacterial species has not been systematically characterized. Here, we quantified the patterns of introgression across 50 major bacterial lineages. Our results reveal that bacteria present various levels of introgression, with an average of 2% of introgressed core genes and up to 12% in Campylobacter. Furthermore, our results show that some species are more prone to introgression than others within the same genus and introgression is most frequent between highly related species. We found evidence that the various levels of introgression across lineages are likely related to ecological proximity between species. Introgression can occasionally lead to fuzzy species borders, although many of these cases are likely instances of ongoing speciation. Overall, our results indicate that introgression has substantially shaped the evolution and the diversification of bacteria, but this process does not substantially blur species borders.

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Comparative Genomic Analysis Reveals Genetic Diversity and Pathogenic Potential of Haemophilus seminalis and Emended Description of Haemophilus seminalis

Cited by 4 publications

References 73 publications

Genome Characterisation of Invasive Haemophilus influenzae in Pregnancy: The Noticeable Placental Tissue Tropism Is Distributed across the Species Rather Than Linked with Capsulation or Particular Clones

Genome Characterisation of Invasive Haemophilus influenzae in Pregnancy: The Noticeable Placental Tissue Tropism Is Distributed across the Species Rather Than Linked with Capsulation or Particular Clones

Comparative genomic study of non-typeable Haemophilus influenzae in children with pneumonia and healthy controls

Introgression impacts the evolution of bacteria, but species borders are rarely fuzzy

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