Comparative genomic hybridization analysis of hepatoblastomas

Hu, Jie; Wills, Marcia L.; Baker, Barbara A.; Perlman, Elizabeth J.

doi:10.1002/(sici)1098-2264(200002)27:2<196::aid-gcc12>3.0.co;2-d

Cited by 38 publications

(27 citation statements)

References 34 publications

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“…It will be interesting to evaluate these two parameters as predictors of tumor recurrence in HB patients. Most chromosomal alterations found by cytogenetic array in parental tumors and PDX samples have been described . Particularly, gain of chromosomes 8, 17, and, above all, 20 are more frequent than in previous reports, where the incidence of gains of chromosomes 8/8q and 20 was 15% and 24% in HBs, respectively .…”

Section: Discussionmentioning

confidence: 81%

Patient‐derived mouse xenografts from pediatric liver cancer predict tumor recurrence and advise clinical management

Nicolle¹,

Fabrè

Simon-Coma

et al. 2016

Hepatology

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Section: Discussionmentioning

confidence: 81%

Patient‐derived mouse xenografts from pediatric liver cancer predict tumor recurrence and advise clinical management

Nicolle¹,

Fabrè

Simon-Coma

et al. 2016

Hepatology

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“…21,22) In contrast, frequent gain of 2q has been reported only in ovarian carcinoma by CGH analysis. 23) Recently, three groups of investigators reported frequent gain of 2/2q in hepatoblastomas by [6][7][8] Two of them reported high-level gain in a restricted region at 2q24. 7,8) The present study also showed a partial 2q gain in 6 tumors by CGH analysis, and identified 2q24 as the most common region for DNA copy gain (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5] Recently, comparative genomic hybridization (CGH) analysis has been performed in 3 series of hepatoblastomas, which confirmed cytogenetic findings reported previously. [6][7][8] Although most hepatoblastomas are sporadic, they also occur in association with Beckwith-Wiedemann (B-W) syndrome and familial adenomatous polyposis (FAP). 9,10) APC mutation and/or loss of heterozygosity in the APC locus were reported in some children with both sporadic and the FAP-associated hepatoblastomas.…”

Section: Abstract: Hepatoblastoma -Cgh -Fish -Chromosome Abnormalitimentioning

confidence: 99%

Frequent Increase of DNA Copy Number in the 2q24 Chromosomal Region and Its Association with a Poor Clinical Outcome in Hepatoblastoma: Cytogenetic and Comparative Genomic Hybridization Analysis

Kumon

Kobayashi

Namiki

et al. 2001

Japanese Journal of Cancer Research

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In a cytogenetic and comparative genomic hybridization (CGH) study of 38 hepatoblastomas, we found gain of 1q in 17 tumors (44.7%), that of 2/2q in 14 (36.8%), that of 20/20q in 9 (23.7%) and that of 8/8q in 8 (21.0%), loss of 4q in 4 (10.5%) and no DNA copy changes with normal karyotype or no mitotic cells in 11 (28.9%). Eleven tumors with 2/2q gain detected by CGH had a total chromosome 2 gain, a partial 2q gain, or a total chromosome 2 gain with an augmented partial 2q region; the common region for DNA copy gain was 2q24. Two-color fluorescence in situ hybridization (FISH) analyses using probes covering the centromere of chromosome 2 or HOXD13 (2q31) confirmed the CGH findings, and showed that the common region for gain in 2q was centromeric to HOXD13. Event-free survival (EFS) ± ± ± ±standard error (SE) at 5 years was lowest in patients with 2q gain [37 ± ± ± ±15%], highest in those with no DNA copy changes [82± ± ± ±12%], and intermediate in those with DNA copy changes other than 2q gain [74 ± ± ± ±13%] (P = = = =0.0549). Multivariate analysis showed that 2q gain was an independent factor predicting a poor outcome. These findings suggest the presence of a growth-promoting gene or an oncogene in the 2q24 chromosome band, and a tumor suppressor gene in terminal 4q, which have important roles in the development and progression of hepatoblastoma.

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“…CGH was performed as previously described. 18 The SYSTAT 9 program was used for Kaplan-Meier survival curves and Breslow-Gehan log-rank analysis.…”

Section: Molecular Analysesmentioning

confidence: 99%

hTERT Gene Amplification and Increased mRNA Expression in Central Nervous System Embryonal Tumors

Fan

Wang

Kratz

et al. 2003

The American Journal of Pathology

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Comparative genomic hybridization analysis of hepatoblastomas

Cited by 38 publications

References 34 publications

Patient‐derived mouse xenografts from pediatric liver cancer predict tumor recurrence and advise clinical management

Patient‐derived mouse xenografts from pediatric liver cancer predict tumor recurrence and advise clinical management

Frequent Increase of DNA Copy Number in the 2q24 Chromosomal Region and Its Association with a Poor Clinical Outcome in Hepatoblastoma: Cytogenetic and Comparative Genomic Hybridization Analysis

hTERT Gene Amplification and Increased mRNA Expression in Central Nervous System Embryonal Tumors

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