Comparative hemodynamic effects of propofol and thiamylal sodium during anesthetic induction for myocardial revascularization

Kaplan, Joel A.; Guffin, Anita V.; Mikula, Suzette; Dolman, John; Profeta, Joseph

doi:10.1016/0888-6296(88)90308-0

Cited by 32 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, other studies in cardiac surgical patients suggest that the drug may cause some myocardial depression in addition to vasodilatation [7,9]. This may be secondary to a reduction in coronary artery blood flow consequent upon hypotension [10].…”

mentioning

confidence: 99%

Effect of Propofol on Peripheral Vascular Resistance During Cardiopulmonary Bypass

Boer¹,

Ros²,

Bovill³

et al. 1990

British Journal of Anaesthesia

View full text Add to dashboard Cite

Twenty-eight patients undergoing elective coronary artery bypass surgery were allocated randomly to receive either propofol 2 mg kg-1 or an equivalent volume of its vehicle during cardiopulmonary bypass with constant pump flow. Peripheral vascular resistance (PVR) was calculated from perfusion pressure and pump flow. After propofol, PVR decreased from 1767 (SD 415) dyn s cm-5 to a minimum of 1263 (283) dyn s cm-5 at 2 min, and remained significantly less than the control value until 12.5 min after administration of propofol. In the group given the vehicle, PVR did not change significantly. In a second study in 10 patients, venous blood samples were withdrawn before and 2, 4, 6, 8, 10, 20 and 30 min after injection of propofol 2 mg kg-1 during cardiopulmonary bypass, for measurement of blood concentrations of propofol. Concentrations were greater than predicted by a computer simulation based on published pharmacokinetic data. The decrease in PVR may be an important factor in the hypotension caused by propofol during induction of anaesthesia.

show abstract

mentioning

confidence: 99%

Effect of Propofol on Peripheral Vascular Resistance During Cardiopulmonary Bypass

Boer¹,

Ros²,

Bovill³

et al. 1990

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Because the mechanism of the action of thiamylal is similar to that of propofol (9), thiamylal might have contributed to lactic acidosis. Other factors might also have contributed to hypotension and acidosis.…”

Section: Discussionmentioning

confidence: 99%

Refractory Hypotension after Cardioversion in a Patient with Atrial Fibrillation and Congestive Heart Failure

et al. 2016

View full text Add to dashboard Cite

A 63-year-old woman with atrial fibrillation visited our hospital due to decompensated heart failure. Because atrial fibrillation was considered a remarkable precipitating factor for heart failure, cardioversion was performed. After cardioversion, refractory hypotension and cardiopulmonary arrest occurred. An arterial blood gas analysis showed marked lactic acidosis. Chronic kidney disease, heart failure, sedatives, and hypoventilation might have contributed to refractory hypotension due to severe acidosis in this case.

show abstract

“…These make propofol useful in the patient with ischaemic heart disease by reducing myocardial work and hence oxygen requirements. Induction in ASA I11 and IV patients may be associated with greater cardiovascular depression than thiopentone, methohexitone or thiamylal (Kaplan et al, 1988;Coley et al, 1989;Lepage et al, 1991); in the presence of acute coronary ischaemia, propofol infusions depress global and regional cardiac function more than in healthy animals (Diedericks et al, 1989;1990 b & c).…”

Section: @) Etomidatementioning

confidence: 99%

Recent Advances in Intravenous Anaesthesia

Sear

1991

Journal of Veterinary Anaesthesia

View full text Add to dashboard Cite

Comparative hemodynamic effects of propofol and thiamylal sodium during anesthetic induction for myocardial revascularization

Cited by 32 publications

References 21 publications

Effect of Propofol on Peripheral Vascular Resistance During Cardiopulmonary Bypass

Effect of Propofol on Peripheral Vascular Resistance During Cardiopulmonary Bypass

Refractory Hypotension after Cardioversion in a Patient with Atrial Fibrillation and Congestive Heart Failure

Recent Advances in Intravenous Anaesthesia

Contact Info

Product

Resources

About