Comparative hemodynamics in an aorta with bicuspid and trileaflet valves

Gilmanov, Anvar; Sotiropoulos, Fotis

doi:10.1007/s00162-015-0364-7

Cited by 38 publications

(26 citation statements)

References 49 publications

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“…In the present study, the formation and dissipation of vortex rings were observed in all three valve designs during the opening stage. The vortex rings of all the valves were bending towards the flow direction with lobes near the commissures at the early stage of acceleration and separated into small-scale vortices at the acceleration peak, which agrees well with the results from FSI studies on prosthetic aortic valves [37,102]. The vortex distribution in the SPAC molded valve case is similar to that in the case with a conventional valve, and a more complex vortex structure within the valve section was observed in the SPAC tubular valve at the acceleration peak.…”

Section: Vortex Distributionsupporting

confidence: 87%

Numerical Investigation of the Effects of Prosthetic Aortic Valve Design on Aortic Hemodynamic Characteristics

Zhu

Huang

et al. 2020

Applied Sciences

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The superior performance of single-point attached commissures (SPAC) molded valve design has been validated by several numerical, in vitro and in vivo animal studies. However, the impacts of the SPAC molded valve design on aortic hemodynamic environments are yet to be investigated. In this study, multiscale computational models were prepared by virtually implanting prosthetic aortic valves with SPAC tubular, SPAC molded and conventional designs into a patient-specific aorta, respectively. The impacts of the valve designs on efferent flow distribution, flow pattern and hemodynamic characteristics in the aorta were numerically investigated. The results showed that despite the overall flow phenomena being similar, the SPAC tubular valve exhibited a suboptimal performance in terms of higher spatially averaged wall shear stress (SAWSS) in ascending aorta (AAo), higher helix grade, stronger secondary flow mean secondary velocity in descending aorta, as well as more complex vortex distribution. The results from the current study extend the understanding of hemodynamic impacts of the valve designs, which would further benefit the optimization of the prosthetic aortic valve.

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Section: Vortex Distributionsupporting

confidence: 87%

Numerical Investigation of the Effects of Prosthetic Aortic Valve Design on Aortic Hemodynamic Characteristics

Zhu

Huang

et al. 2020

Applied Sciences

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“…This info from MRI ( Figure 1) was merely used to orient the leaflets in the model correctly. We simulated the trileaflet aortic valve with the common orientation of its leaflets toward the sinuses (RCC, right coronary cusp; LCC, left coronary cusp; and NCC, non-coronary cusp); see [35]. A nonlinear anisotropic May-Newman-Yin model [30] was used to describe the constitute properties of the leaflet tissue.…”

Section: Computational Detailsmentioning

confidence: 99%

Image-Guided Fluid-Structure Interaction Simulation of Transvalvular Hemodynamics: Quantifying the Effects of Varying Aortic Valve Leaflet Thickness

Gilmanov

Barker

Stolarski

et al. 2019

Fluids

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When flow-induced forces are altered at the blood vessel, maladaptive remodeling can occur. One reason such remodeling may occur has to do with the abnormal functioning of the aortic heart valve due to disease, calcification, injury, or an improperly-designed prosthetic valve, which restricts the opening of the valve leaflets and drastically alters the hemodynamics in the ascending aorta. While the specifics underlying the fundamental mechanisms leading to changes in heart valve function may differ from one cause to another, one common and important change is in leaflet stiffness and/or mass. Here, we examine the link between valve stiffness and mass and the hemodynamic environment in aorta by coupling magnetic resonance imaging (MRI) with high-resolution fluid-structure interaction (FSI) computational fluid dynamics to simulate blood flow in a patient-specific model. The thoracic aorta and a native aortic valve were re-constructed in the FSI model from the MRI data and used for the simulations. The effect of valve stiffness and mass is parametrically investigated by varying the thickness (h) of the leaflets (h = 0.6, 2, 4 mm). The FSI simulations were designed to investigate systematically progressively higher levels of valve stiffness by increasing valve thickness and quantifying hemodynamic parameters known to be linked to aortopathy and valve disease. The computed results reveal dramatic differences in all hemodynamic parameters: (1) the geometric orifice area (GOA), (2) the maximum velocity V max of the jet passing through the aortic orifice area, (3) the rate of energy dissipationĖ diss (t), (4) the total loss of energy E diss , (5) the kinetic energy of the blood flow E kin (t), and (6) the average magnitude of vorticity Ω a (t), illustrating the change in hemodynamics that occur due to the presence of aortic valve stenosis.

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“…The valve leaflet models of Griffith and Borazjani suffered from deficiencies; Griffith applied Peskin’s original connected markers; while Borazjani omitted bending stiffness. The CURVIB method was recently extended to include fluid-shell structure interaction by Gilmanov et al ., 57,58 but the efficacy of the approach has not yet been demonstrated for the portion of the cardiac cycle in which the leaflets are coapted and must support large transvalvular pressure differentials. Kamensky et al .…”

Section: Computational Simulationsmentioning

confidence: 99%

Biomechanical Behavior of Bioprosthetic Heart Valve Heterograft Tissues: Characterization, Simulation, and Performance

Soares

Feaver

Zhang

et al. 2016

Cardiovasc Eng Tech

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The use of replacement heart valves continues to grow due to the increased prevalence of valvular heart disease resulting from an ageing population. Since bioprosthetic heart valves (BHVs) continue to be the preferred replacement valve, there continues to be a strong need to develop better and more reliable BHVs through and improved the general understanding of BHV failure mechanisms. The major technological hurdle for the lifespan of the BHV implant continues to be the durability of the constituent leaflet biomaterials, which if improved can lead to substantial clinical impact. In order to develop improved solutions for BHV biomaterials, it is critical to have a better understanding of the inherent biomechanical behaviors of the leaflet biomaterials, including chemical treatment technologies, the impact of repetitive mechanical loading, and the inherent failure modes. This review seeks to provide a comprehensive overview of these issues, with a focus on developing insight on the mechanisms of BHV function and failure. Additionally, this review provides a detailed summary of the computational biomechanical simulations that have been used to inform and develop a higher level of understanding of BHV tissues and their failure modes. Collectively, this information should serve as a tool not only to infer reliable and dependable prosthesis function, but also to instigate and facilitate the design of future bioprosthetic valves and clinically impact cardiology.

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Comparative hemodynamics in an aorta with bicuspid and trileaflet valves

Cited by 38 publications

References 49 publications

Numerical Investigation of the Effects of Prosthetic Aortic Valve Design on Aortic Hemodynamic Characteristics

Numerical Investigation of the Effects of Prosthetic Aortic Valve Design on Aortic Hemodynamic Characteristics

Image-Guided Fluid-Structure Interaction Simulation of Transvalvular Hemodynamics: Quantifying the Effects of Varying Aortic Valve Leaflet Thickness

Biomechanical Behavior of Bioprosthetic Heart Valve Heterograft Tissues: Characterization, Simulation, and Performance

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