2016
DOI: 10.9734/bjpr/2016/22379
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Comparative Hepatic Effects of Hippocratea africana Root Bark Extract on Female and Male Albino Wistar Rats

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Cited by 3 publications
(5 citation statements)
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“…Tannins have been reported to inhibit oxidation of LDL-cholesterol, reduce body fat and thereby decrease incidence of heart disease [41]. The dose-dependent decrease in the concentration of troponin observed in this study may also indicate that the herb did not cause any oxidative stress in the [16]. This further shows that the herb did not induce oxidative stress and may be cardio protective.…”
Section: Discussionsupporting
confidence: 56%
See 1 more Smart Citation
“…Tannins have been reported to inhibit oxidation of LDL-cholesterol, reduce body fat and thereby decrease incidence of heart disease [41]. The dose-dependent decrease in the concentration of troponin observed in this study may also indicate that the herb did not cause any oxidative stress in the [16]. This further shows that the herb did not induce oxidative stress and may be cardio protective.…”
Section: Discussionsupporting
confidence: 56%
“…The root bark of the plant is used traditionally in the treatment of various ailments such as malaria, fever, body pains, diabetes, and diarrhea [13]. Its antimalarial property has been reported in mice [13] and there are many reports on some of its effects on biochemical parameters [14][15] [16] [17]. The root bark extract of the herb is used traditionally by people in the South Eastern part of Nigeria for the treatment of malaria.…”
Section: Introductionmentioning
confidence: 99%
“…Its effect on some biochemical indices, lipid profile, comparative hepatic effect and antidiarrhoeal and antiulcer activities have been reported. 2,14,15,16 Despite its reported promising antimalarial property and favourable effects on biochemical parameters, its effects on reproductive indices have not been reported. This study is designed to evaluate the testosterone concentration and testicular histomorphological changes following its administration on male albino Wistar rats.…”
Section: Introductionmentioning
confidence: 99%
“…In this study, ALT showed slight surges in groups B and C when compared with the control group, though not significant, a similar trend was observed for AST concentration. Ndem and Ewere (2016) demonstrated that slight increases in ALT and AST were detected after H. africana root bark administration at 100 and 200 mg/kg, indicating mild hepatocellular damages, and that the male Wistar rats expressed elevated liver enzymes than their female counterparts. However, ALP was significantly elevated, and mild elevations of ALP may signal liver disease, which may plausibly be due to overproduction or/and leakage in blood (Thapa and Walia, 2007).…”
Section: Discussionmentioning
confidence: 97%
“…Hippocratea africana is a plant of medicinal value from the family Hippocrateaceae, a perennial climber that can be cultivated from seeds, and possesses in vivo antiplasmodial activity in mice (Okokon et al, 2006), improves antioxidant levels in hepatocytes (Okokon et al, 2013), promotes erythropoiesis, and reduces artherosclerotic coronary disease markers (Ndem et al, 2014). The root bark extract of Hippocratea africana induces mild toxicity by altering the liver enzymes and histology of Wistar rats (Ndem and Ewere, 2016), but an earlier study had suggested that at doses of 100 to 300 mg/kg body weight of rats, the root extract of Hippocratea africana did not cause liver or kidney derangements (Ndem et al, 2013). However, demonstrated that root bark extract Hippocratea africana at 100 to 300 mg/kg body weight induced homeostatic pertubations in experimental rats, though with no apparent renal distortion of the histoarchitecture, and but concluded that the concentration of creatinine be re-evaluated to confirm possible distortion to the renal function.…”
Section: Introductionmentioning
confidence: 99%