Comparative histopathological study of the venous wall of chronic venous insufficiency and varicose disease

Dhanarak, Nisarat; Kanchanabat, Burapa

doi:10.1177/0268355515610709

Cited by 4 publications

(1 citation statement)

References 12 publications

(26 reference statements)

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“…Лікування ран є найдавнішою проблемою хірургії [8]. Незважаючи на появу хірургічних і медикаментозних інновацій, лікування хронічних ран є тривалим та часто безуспішним [4,24]. Поширеність виразок ніг серед населення становить 0,1-1,5%, у 24% хворих тривалість їх наявності сягає більше року.…”

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The problem of chronic wounds and the possibility of using mesenchymal stem cells in their treatment

Slobodyanyk¹,

Хіміч²,

Shkolnikov³

2020

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. A review of scientific publications on the problems of chronic wounds and issues of innovative use of mesenchymal stem cells in the treatment of patients with chronic wound defects is presented. We have conducted a systematic review of PubMed and Google Scholar database articles over the past 34 years (1985–2019), more than half of which over the past 5 years. The search terms “chronic wound”, “mesenchymal stem cells” were used during the search. It should be noted that despite the fact that the treatment of wounds and wound infection belongs to the category of the oldest branches of medicine, the treatment of chronic wounds in Ukraine today remains one of the important problems in the treatment of inflammatory soft tissue diseases. None of the many proposed methods and techniques for the treatment of chronic wounds satisfies practical surgeons completely. The results of the treatment of chronic wounds to date remain unsatisfactory. Prospects for the use of mesenchymal stem cells in the treatment of chronic wounds is important and further research.

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The problem of chronic wounds and the possibility of using mesenchymal stem cells in their treatment

Slobodyanyk¹,

Хіміч²,

Shkolnikov³

2020

Rep. of Vinnytsia Nation. Med. Univ.

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References

2022

Genesis, Pathophysiology and Management of Venous and Lymphatic Disorders

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Interleukin-13: association with inflammation and cysteine proteolysis in varicose transformation of the vascular wall

Kalinin,

Konopleva,

Suchkov

et al. 2023

Kazan Med J

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The present review considers current data on the structure, functions and role of interleukin-13 in the pathogenesis of vascular wall varicose transformation in terms of proteolysis and inflammatory response. It is known that interleukin-13 is able to interact with transforming growth factor-1 in diseases associated with fibrosis. The latter activates fibroblasts and excessive formation of the extracellular matrix, thereby inducing fibrosis of the vascular wall, which is one of the links in the pathogenesis of varicose veins. Also, to date, there is evidence of the interleukin-13 participation in the induction of certain proteolytic enzymes synthesis, such as matrix metalloproteinases. For the latter, participation in the transformation of the venous wall has been proven to date. The remodeling of the venous wall itself can lead to an increase in the expression of proteinases, providing a proteolytic mechanism for changing the structural organization of the venous wall in varicose veins of the lower extremities. At the same time, the involvement of lysosomal cysteine proteinases remains poorly understood. The expression and production of individual cathepsins are regulated by biologically active molecules: interleukin-1, interleukin-6, tumor necrosis factor , which are directly involved in inflammatory reactions in the wall of varicose veins. In particular, venous pathology develops in a vicious circle of inflammation with the formation of abnormal venous blood flow, chronic venous hypertension and dilation, and the recruitment of leukocytes. This leads to a further, deeper, remodeling of the walls and valves of the veins, an increase in blood pressure and the release of pro-inflammatory mediators chemokines and cytokines. In connection with the above, in order to understand the mechanisms of proteolysis in the vascular wall in varicose veins of the lower extremities, it is important to have an idea about the possible interactions of interleukin-13 with transforming growth factor-1, inflammatory cytokines, and cathepsins.

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Comparative histopathological study of the venous wall of chronic venous insufficiency and varicose disease

Abstract: Compared with C2 vein, the intimal changes in chronic venous insufficiency venous wall differ, particularly in the VCSS 0, 1 chronic venous insufficiency.

Cited by 4 publications

References 12 publications

The problem of chronic wounds and the possibility of using mesenchymal stem cells in their treatment

The problem of chronic wounds and the possibility of using mesenchymal stem cells in their treatment

References

Interleukin-13: association with inflammation and cysteine proteolysis in varicose transformation of the vascular wall

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