2020
DOI: 10.3390/vaccines8040756
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Comparative Immunological Study in Mice of Inactivated Influenza Vaccines Used in the Russian Immunization Program

Abstract: A series of commercial inactivated influenza vaccines (IIVs) used in the Russian National Immunization Program were characterized to evaluate their protective properties on an animal model. Standard methods for quantifying immune response, such as hemagglutination inhibition (HAI) assay and virus neutralization (VN) assay, allowed us to distinguish the immunogenic effect of various IIVs from that of placebo. However, these standard approaches are not suitable to determine the role of various vaccine components… Show more

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Cited by 4 publications
(5 citation statements)
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“…The antigenic competition between HA and NA has been postulated, which is mainly due to the larger number of HA proteins found on the virion surface and their amplified presentation to the antigen-recognition cells of the immune system [42]. The amount of NA in vaccines also differs depending on the proportions of HA and NA in each strain.…”
Section: Discussionmentioning
confidence: 99%
“…The antigenic competition between HA and NA has been postulated, which is mainly due to the larger number of HA proteins found on the virion surface and their amplified presentation to the antigen-recognition cells of the immune system [42]. The amount of NA in vaccines also differs depending on the proportions of HA and NA in each strain.…”
Section: Discussionmentioning
confidence: 99%
“…The antigenic competition between HA and NA has been postulated, which is mainly due to the larger number of HA proteins found on the virion surface and its amplified presentation to the antigen-recognition cells of the immune system [42]. The amount of NA in vaccines also differs depending on the proportions of HA and NA in each strain.…”
Section: Discussionmentioning
confidence: 99%
“…В отличие от нашего исследования, группы животных были небольшими (n = 6); сами животные были трансгенными Tg (K18-hACE2) для изучения АТ-зависимого эффекта; иммунизация вакциной для профилактики гриппа была проведена однократно [11]. В нашем же исследовании мыши линии BALB/c были привиты дважды гриппозной вакциной, как было описано ранее [13].…”
Section: Discussionunclassified
“…Реакцию торможения гемагглютинации (РТГА) проводили в соответствии с протоколом ВОЗ [12] по ранее описанной методике [13]…”
Section: материалы и методыunclassified