Comparative in vitro studies on PBN loaded nanoparticles prepared by biodegradable chitosan, PLGA polymers and their PEGylated block copolymers

Öztürk, Kıvılcım; Fernández-Megía, Eduardo; Novoa-Carballal, Ramón; Riguera, Ricardo; Yemişçi, Müge; Gürsoy‐Özdemir, Yasemin; Dalkara, Turgay; Couvreur, P.; Çapan, Yılmaz

doi:10.1016/s1773-2247(14)50024-x

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…For example the value for the particles of PEG‐ b ‐PLGA ( 15 ) of −15 mV is in good agreement with previously published data . Introduction of PEG into PLGA polymers increases the surface charge what can be caused by the shielding effect of PEG and is additionally influenced by the particle size (distance to the surface) . Scanning electron microscopy (SEM) revealed a spherical shape of the formed nanoparticles (Fig.…”

Section: Resultssupporting

confidence: 90%

“…The zeta potential (ζ) for the PEG‐ b ‐PLGA and PEG‐ b ‐PAGE‐ b ‐PLGA nanoparticles increases comparing to pure PLGA particles (around −60 mV) as described in literature. For example the value for the particles of PEG‐ b ‐PLGA ( 15 ) of −15 mV is in good agreement with previously published data . Introduction of PEG into PLGA polymers increases the surface charge what can be caused by the shielding effect of PEG and is additionally influenced by the particle size (distance to the surface) .…”

Section: Resultssupporting

confidence: 90%

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Functionalized PEG‐b‐PAGE‐b‐PLGA triblock terpolymers as materials for nanoparticle preparation

Czaplewska

Majdanski

Barthel

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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A series of poly(ethylene glycol)-block-poly(allyl glycidyl ether) (PEG-b-PAGE) macroinitiators are prepared using the living anionic ring-opening polymerization (AROP) technique, and applied for further copolymerization studies. To overcome the low reactivity of the secondary hydroxyl endgroup of the PAGE block, a primary hydroxyl group is introduced into the macroinitiators via trityl and tert-butyl-dimethylsilane protective groups. The modified macroinitiators are used for copolymerization by applying different amounts of PEG-b-PAGE (5, 10, and 15%) and different PLGA lengths. To study their properties, nanoparticles from selected polymers are prepared and characterized by dynamic light scattering and scanning electron microscopy showing spherical particles with diameters around 200 nm and low PDI particle values of 0.03-0.1. An advantage of the obtained polymers is the presence of double bonds in the side chain, which enables the modification via, for example, thiol-ene reactions. For this purpose tertiary 2-(dimethylamino)ethanethiol), acetylated thiogalactose and thiomannose are attached onto the double bonds of the PAGEblocks.

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Section: Resultssupporting

confidence: 90%

Section: Resultssupporting

confidence: 90%

Functionalized PEG‐b‐PAGE‐b‐PLGA triblock terpolymers as materials for nanoparticle preparation

Czaplewska

Majdanski

Barthel

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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Novel advances in targeted drug delivery

Öztürk-Atar

Eroğlu

Çalış

2017

Journal of Drug Targeting

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Developing a new drug molecule is not only time-consuming and expensive, but also mostly a failing process. However, improving bioavailability, targetability, efficacy or safety of old drugs could be more effective way to use them in clinic. For these purposes, so many strategies including individualising drug therapy, nanoparticle-based drug delivery systems, drug conjugates, therapeutic drug monitoring, stimuli-sensitive targeted therapy are investigated intensely. Depending on the desired application or targeted site, nanoparticles can be administrated as orally, locally, topically and systemically. Currently, the Food and Drug Administration and the European Medicines Agency approved nanoparticles are mostly aimed to treat cancer. Although some of these formulations were approved by Food and Drug Administration and/or European Medicines Agency to use in clinic, most of them have fell down to pass either pre-clinical or clinical trials. To have high approval rate, failure reasons need to be better understand.

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Preparation andin vitroevaluation of 5-fluorouracil-loaded PCL nanoparticles for colon cancer treatment

Öztürk

Mashal

Yegin

et al. 2015

Pharmaceutical Development and Technology

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Nanoparticles loaded with 5-fluorouracil (5-FU) for colon cancer therapies were prepared using the solvent evaporation technique, which involved lyophilization by freeze-drying. Formulations produced a substantially high encapsulation efficiency of approximately 93%. A positive correlation was seen when increasing polycaprolactone (PCL) and/or PVA concentrations and the size of nanoparticles produced. Increasing PCL concentration had a considerable influence on PDI while increasing PVA concentration had a lesser effect. All nanoparticles possessed a negative zeta potential, particularly in formulations with low polymer and polymer emulsifier concentrations. The formulation with the lowest PCL and PVA concentration was characterized by the most optimal properties; which accounts for the desirable delayed release profile of the active drug in dissolution testing indicating an improved targeting capability and enhanced bioavailability at the action site. Cytotoxicity studies showed that 5-FU loaded PCL nanoparticles had higher antiproliferative effect than free 5-FU on Caco-2 cell line (p < 0.05). The encouraging results obtained offer reasons for optimism regarding the future of 5-FU nanoparticles as a promising drug delivery system which could be further improved by including either enteric coating or encapsulating the nanoparticles onto microparticles to overcome unanticipated degradation.

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Comparative in vitro studies on PBN loaded nanoparticles prepared by biodegradable chitosan, PLGA polymers and their PEGylated block copolymers

Cited by 4 publications

References 17 publications

Functionalized PEG‐b‐PAGE‐b‐PLGA triblock terpolymers as materials for nanoparticle preparation

Functionalized PEG‐b‐PAGE‐b‐PLGA triblock terpolymers as materials for nanoparticle preparation

Novel advances in targeted drug delivery

Preparation andin vitroevaluation of 5-fluorouracil-loaded PCL nanoparticles for colon cancer treatment

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