Comparative in vitro study of cholinium-based ionic liquids and deep eutectic solvents toward fish cell line

Radošević, Kristina; Železnjak, Jelena; Bubalo, Marina Cvjetko; Redovniković, Ivana Radojčić; Slivac, Igor; Srček, Višnja Gaurina

doi:10.1016/j.ecoenv.2016.05.005

Cited by 63 publications

(33 citation statements)

References 37 publications

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“…Nonetheless, this cytotoxicity is not as pronounced as for ILs containing alkyl side chains, such as imidazole-based ionic liquids [24]. Furthermore, and even though, the toxicity of ILs has been mostly attributed to the cation, particularly the type of cationic head group and the length of the alkyl side chain, it is also known that the type of anion may have some impact on this toxicity [43], which justifies the observed differences between the two studied ILs. In fact, it has been shown that different amino acids lead to different cytotoxicities, with the elongation of the amino acid side chain being one of the structural contributions to enhance their cytotoxicity, although the toxicity sequence may differ depending on the model system used [43].…”

Section: Discussionmentioning

confidence: 85%

Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells

et al. 2020

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The renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel and more effective therapies, while minimizing toxicity, continues to be fundamental in curtailing RCC. Rutin, a bioflavonoid widely found in nature, has shown promising anticancer properties, but with limited applicability due to its poor water solubility and pharmacokinetics. Thus, the potential anticancer effects of rutin toward a human renal cancer cell line (786-O), while considering its safety in Vero kidney cells, was assessed, as well as the applicability of ionic liquids (ILs) to improve drug delivery. Rutin (up to 50 µM) did not show relevant cytotoxic effects in Vero cells. However, in 786-O cells, a significant decrease in cell viability was already observed at 50 µM. Moreover, exposure to rutin caused a significant increase in the sub-G1 population of 786-O cells, reinforcing the possible anticancer activity of this biomolecule. Two choline-amino acid ILs, at non-toxic concentrations, enhanced rutin’s solubility/loading while allowing the maintenance of rutin’s anticancer effects. Globally, our findings suggest that rutin may have a beneficial impact against RCC and that its combination with ILs ensures that this poorly soluble drug is successfully incorporated into ILs–nanoparticles hybrid systems, allowing controlled drug delivery.

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Section: Discussionmentioning

confidence: 85%

Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells

et al. 2020

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“…Cholinium‐based ILs with perfluoroalkanoate anions exhibit safe profiles for the selected cell lines (i.e., MRC‐5, Huh‐7, and HEK 293) . Radošević et al . have established that the cholinium cation combined with amino acids and DESs are less toxic to channel catfish ovary (CCO) cells than conventional ILs, such as imidazolium‐ and pyridinium‐based ILs.…”

Section: Toxicological Impact Of Ionic Liquidsmentioning

confidence: 99%

Environmental Impact of Ionic Liquids: Recent Advances in (Eco)toxicology and (Bio)degradability

et al. 2017

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This Review aims to integrate the most recent and pertinent data available on the (bio)degradability and toxicity of ionic liquids for global and critical analysis and on the conscious use of these compounds on a large scale thereafter. The integrated data will enable focus on the recognition of toxicophores and on the way the community has been dealing with them, with the aim to obtain greener and safer ionic liquids. Also, an update of the most recent biotic and abiotic methods developed to overcome some of these challenging issues will be presented. The review structure aims to present a potential sequence of events that can occur upon discharging ionic liquids into the environment and the potential long-term consequences.

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“…Early advances were motivated to develop ILs as green, nonvolatile, nonflammable, and stable solvents, however, recent findings have broadened the field, redefining ILs as low melting salts (melting point <100°C) with an unlimited suite of tunable properties including toxicity, volatility, flammability, and instability . The erstwhile narrow perspective that views ILs as salts of quaternary ammonium, imidazolium, pyrrolidinium, pyridinium, or phosphonium cations has broadened as new cations including the bioinspired cholinium and guanidinium cations as well as metal‐containing cations are paired with various anions to afford salts that meet the definition of IL (Figure ). The evolving complexity of the precursors fosters a conjecture that explains their characteristically low melting point by the structural heterogeneity of a sterically hindered asymmetric cation that impedes strong ionic interaction with the anion as well as precludes ordered packing within a crystal lattice.…”

Section: Introductionmentioning

confidence: 99%

Ionic liquids for addressing unmet needs in healthcare

Agatemor¹,

Ibsen²,

Tanner³

et al. 2018

Bioengineering & Transla Med

141

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Advances in the field of ionic liquids have opened new applications beyond their traditional use as solvents into other fields especially healthcare. The broad chemical space, rich with structurally diverse ions, and coupled with the flexibility to form complementary ion pairs enables task‐specific optimization at the molecular level to design ionic liquids for envisioned functions. Consequently, ionic liquids now are tailored as innovative solutions to address many problems in medicine. To date, ionic liquids have been designed to promote dissolution of poorly soluble drugs and disrupt physiological barriers to transport drugs to targeted sites. Also, their antimicrobial activity has been demonstrated and could be exploited to prevent and treat infectious diseases. Metal‐containing ionic liquids have also been designed and offer unique features due to incorporation of metals. Here, we review application‐driven investigations of ionic liquids in medicine with respect to current status and future potential.

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Comparative in vitro study of cholinium-based ionic liquids and deep eutectic solvents toward fish cell line

Cited by 63 publications

References 37 publications

Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells

Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells

Environmental Impact of Ionic Liquids: Recent Advances in (Eco)toxicology and (Bio)degradability

Ionic liquids for addressing unmet needs in healthcare

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