Comparative in vivo assessment of the subacute toxicity of gold and silver nanoparticles

Rathore, Mansee; Mohanty, Ipseeta Ray; Maheswari, Ujjwala; Dayal, Navami; Suman, Rajesh Kumar; Joshi, Dattatraya

doi:10.1007/s11051-014-2338-x

Cited by 23 publications

(20 citation statements)

References 22 publications

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“…Histology findings revealed myocyte apoptosis, inflammation, and fibrosis. Furthermore, Rathore et al (35) concluded that the heart muscle fibers treated with AgNPs demonstrated mild edema and separation of myofibrils. In addition, Adeyemi and Faniyan (36) documented that AgNPs cause inflammation, loss of cross striation with myocardial degeneration and cellular alteration in the cardiac tissue of male Wistar rats.…”

Section: Discussionmentioning

confidence: 99%

Cardiotoxicity and lung toxicity in male rats induced by long‑term exposure to iron oxide and silver nanoparticles

2019

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Engineered nanoparticles (NPs) have been increasingly used in numerous fields over the last decade. In particular, iron oxide NPs (Fe2O3NPs) and silver NPs (AgNPs) have contributed to the current increase in NP usage. However, the possible side effects of increased NP exposure remain not fully elucidated. The present study aimed to assess the toxic effects of Fe2O3NPs and AgNPs, both individually and in combination, on the heart and lungs of male rats. To evaluate the in vivo NP toxic effects, the experimental animals were orally administered with Fe2O3NPs (5 mg/kg) and/or AgNPs (50 mg/kg). Animals were treated every day for 79 days. The results demonstrated that at the molecular level, Fe2O3NPs and AgNPs caused marked DNA base oxidation as indicated by the elevated DNA content of 8-hydroxy-2−deoxyguanosine in the heart and lungs. Fe2O3NPs and/or AgNPs decreased paraoxonase 1, antioxidant enzymes, total antioxidant capacity, and reduced glutathione in heart and lung. A dose-dependent increase in production of creatine kinase, thiobarbituric acid-reactive substances, nitric oxide end products, tumor necrosis factor-α, interleukin-6 and lipid profiles was detected. Histological changes were also evident in heart and lung tissues. The two NPs demonstrated similar toxic effects for the majority of factors when co-supplemented. In conclusion, the present study identified that Fe2O3NPs and AgNPs, alone and in combination, induced cardiotoxicity and lung toxicity. Furthermore, findings demonstrated that there was a greater toxic effect due to administration of both NPs compared to individual administration. It was hypothesized that the toxic effects may be mediated through the induction of oxidative DNA damage, lipid peroxidation, shifting redox status, disrupted gene expression, and deregulation in cytokine production.

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Section: Discussionmentioning

confidence: 99%

Cardiotoxicity and lung toxicity in male rats induced by long‑term exposure to iron oxide and silver nanoparticles

2019

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“…Some studies, however, have reported evidence of toxicological behavior of AuNPs in these animals during investigation for use in biomedical application. For example, no short-term toxicity was observed in dogs with prostate cancer following a single intralesional injection of radioactive AuNPs coated with GA-AuNPs, 104,209 Gum arabic-coated AuNPs (GA-AuNPs, 12-15 nm), used as X-ray contrast agent for tumor imaging, was intratumorally injected to mice with breast cancer and to a dog presented with thyroid carcinoma and osteosarcoma and induced no toxicity. 210 There was also no noted toxicity in pig intravenously injected with GA-AuNPs (15-20 nm).…”

Section: Determination Of the In Vivo Toxicity Of Aunpsmentioning

confidence: 99%

Toxicological Behavior of Gold Nanoparticles on Various Models: Influence of Physicochemical Properties and Other Factors

et al. 2019

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Potential applications of gold nanoparticles in biomedicine have increasingly been reported on account of the ease of synthesis, bioinert characteristics, optical properties, chemical stability, high biocompatibility, and specificity. The safety of these particles remains a great concern, as there are differences among toxicity study protocols used. This article focuses on integrating results of research on the toxicological behavior of gold nanoparticles. This can be influenced by the physicochemical properties, including size, shape, surface charge, and other factors, such as methods used in the synthesis of gold nanoparticles, models used, dose, in vivo route of administration, and interference of gold nanoparticles with in vitro toxicity assay systems. Several researchers have reported toxicological studies with regard to gold nanoparticles, using various in vitro, in vivo, and in ovo models. The conflicting results concerning the toxicity of gold nanoparticles should thus be addressed to justify the safe use of gold nanoparticles in biomedicine.

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“…The toxicity of NPs not only depends on their physiochemical properties but also the difference in experimental conditions in vivo [ 22 , 23 ]. Most acute and subacute toxicity studies revealed a low or nontoxic effect of colloidal AuNPs, while others showed conflicting results [ 10 , 24 , 25 ]. It appears that AuNPs toxicity is not determined by single determinants but rather by multiple factors [ 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…[ 8 ] 10–25 Citrate Male Wistar rats Oral 0.02 21 + Rathore et al. [ 25 ] 5–15 Citrate Female SD rats Oral 0.325–1.3 14 – Jo et al. [ 34 ] 1–25 Polyphenol d Male Wistar rats Oral 5 and 10 28 - Mata et al.…”

Section: Discussionmentioning

confidence: 99%

Subchronic oral toxicity evaluation of gold nanoparticles in male and female mice

Sun

Lai

Hung³

et al. 2021

Heliyon

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Gold nanoparticles (AuNPs) are biocompatible nanomaterials with potential application in the food industry. The safety of AuNPs oral consumption remains inconclusive, and information on possible long-term toxicity is limited. The current study aimed to evaluate the subchronic oral toxicity of AuNPs in male and female Institute of Cancer Research (ICR) mice. Citrate-coated spherical AuNPs with 53 nm diameters were prepared and orally administered to the mice. No mortality or clinical abnormalities were observed following daily administration of AuNPs at the dosages of 0.2, 2, and 20 mg/kg for 90 days. There was no significant difference in body weight or the relative organs' weights between the control and AuNPs-treated mice. No gross abnormalities or histopathological changes were observed except that the male mice treated with high dose (20 mg/kg AuNPs) showed minor infiltration in the kidneys, and female mice showed a reduced A/G ratio and elevated platelet indices. Overall, the 90-day long-term oral consumption of AuNPs did not cause significant toxicity in mice.

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Comparative in vivo assessment of the subacute toxicity of gold and silver nanoparticles

Cited by 23 publications

References 22 publications

Cardiotoxicity and lung toxicity in male rats induced by long‑term exposure to iron oxide and silver nanoparticles

Cardiotoxicity and lung toxicity in male rats induced by long‑term exposure to iron oxide and silver nanoparticles

Toxicological Behavior of Gold Nanoparticles on Various Models: Influence of Physicochemical Properties and Other Factors

Subchronic oral toxicity evaluation of gold nanoparticles in male and female mice

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