Comparative investigation of behavioral, neurotoxicological, and immunotoxicological indices in detection of subacute combined exposure with methyl parathion and propoxur in rats

Institóris, László; Papp, András; Siroki, Olga; Banerjee, B. D.

doi:10.1016/s0147-6513(03)00101-5

Cited by 12 publications

(6 citation statements)

References 33 publications

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“…The eVect of the insecticides on the EPs was, generally, depression. Lengthened latency and duration of EPs was seen in earlier experiments of us after several weeks of treatment with various OPs [8] and with PRP [17]. This time, a single acute dose caused partly similar changes (which was not unexpected, see [32]) albeit the strength of eVect was quite diVerent in the three cortical areas recorded.…”

Section: Discussionsupporting

confidence: 72%

“…Given the known common mechanism [2,13] one would also expect a synergism between DIM and the carbamate PRP. This, however, was not seen and PRP even seemed to antagonize the eVects of DIM; similarly to what was found earlier in a diVerent dosing scheme [17]. The reason for that is not clear but it is possible that the doses, equitoxic in general outcome (i.e., fractions of LD 50 ) are not equitoxic to a speciWc endpoint like cortical activity.…”

Section: Discussionsupporting

confidence: 60%

“…1/10 LD 50 caused a 60% drop in cholinesterase activity and marked disturbances in higher nervous functions [16]. The similarity of the functional neurotoxicity of PRP and an OP (methyl parathion) was demonstrated by Institóris et al [17].…”

Section: Introductionmentioning

confidence: 99%

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Functional neurotoxic effects in rats acutely exposed to insecticide combinations

Lengyel

Szabó

Papp

et al. 2007

Pesticide Biochemistry and Physiology

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Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 60%

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Functional neurotoxic effects in rats acutely exposed to insecticide combinations

Lengyel

Szabó

Papp

et al. 2007

Pesticide Biochemistry and Physiology

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“…Jacobsen et al () reported an increase in relative liver weight in rats exposed, for 28 days, to a mixture of pesticides. Institoris et al () reported that methyl‐parathion, an OP pesticide, increased minimally the relative liver weight in rats exposed to this compound for 6 weeks and suggested that effects of pesticides on organ weights were time dependant.…”

Section: Discussionmentioning

confidence: 99%

Toxic effects of methamidophos on paraoxonase 1 activity and on rat kidney and liver and ameliorating effects of alpha‐tocopherol

Araoud

Neffeti

Khaled

et al. 2014

Environmental Toxicology

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The role of alpha-tocopherol on nephrotoxicity and hepatotoxicity induced by methamidophos (MT) was investigated in wistar rats. Animals were given via gavage, for four weeks, a low dose of MT (MT1), a high dose of MT (MT2), vitamin E (200 mg/kg of bw) or both MT2 plus vitamin E (Vit E) and control group was given distillate water. MT treatment resulted in a significant decrease in the body weight of MT2-treated group. Moreover, MT-treated groups had significantly lower butyrylcholinesterase (p < 0.01) and paraoxonase 1 (PON1) activities compared with the control group (p < 0.05). However, MT2-treated group had significantly higher alkaline phosphatase activity compared with untreated rats (p < 0.05). Both MT-treated groups had significantly higher urea (p < 0.01) and uric acid levels (p < 0.05) compared with the control group. However, significant low uric acid level (p < 0.05) was noted in MT2 plus vit E-treated rats compared with MT2-treated group. Histopathological changes in organ tissues were observed in both MT-treated groups and MT2 plus vit E-treated rats. However, the damage was reduced in MT2 plus vit E-treated rats. Therefore, this study deduces that alpha-tocopherol administration may ameliorate the adverse effects of subacute exposure to MT on rat liver and kidney and this antioxidant can protect PON1 from oxidative stress induced by this organophosphorus pesticide. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 842-854, 2016.

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“…Vaginal smears were obtained from all rats to determine whether they had regular cycles before drug administration. MP and MP ϩ Vit groups were treated by gavage five days a week for four weeks at a dose level of 5 mg/kg body weight MP (0.25 of the acute oral LD 50 ) (Institoris et al, 2004;Gallo et al,1991). Corn oil alone was given in the same way to the control rats.…”

Section: Experimental Designmentioning

confidence: 99%

Fallopian damage induced by organophosphate insecticide methyl parathion, and protective effect of vitamins E and C on ultrastructural changes in rats

et al. 2007

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The aim of the present study was to examine the effects of subchronic methyl parathion (MP) administration on lipid peroxidation and fallopian tube damage, and to evaluate the preventive effects of the use of vitamins E and C against toxicity. The experimental groups were: rats treated with corn oil (control group), with 5 mg/kg MP and with 5 mg/kg body weight MP plus vitamins E and C (MP + Vit). The groups were given MP by oral gavage for five days a week for four weeks at a daily dose of 5 mg/kg (MP and MP + Vit) using corn oil as a vehicle. Vitamins E and C were injected at doses of 50 mg/kg intramuscularly and 20 mg/kg intraperitoneally, respectively, just after the treatment with MP in the MP + Vit group. The levels of malondialdehyde (MDA) were determined in rat plasma. Electron microscopic ultrastuructural and histopathological changes in the fallopian tissue were examined. MDA levels were higher in the MP group than in the control group, and lower in the MP + Vit group than in the MP group. MP led to deletions in microvilli and marked loss in kinocillia of surface epithelium. But these marked histopathological findings decreased in the MP + Vit group. Multiple doses of MP administration caused some damage in the fallopian tube, and treatment with vitamins E and C after MP could reduce this effect.

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Comparative investigation of behavioral, neurotoxicological, and immunotoxicological indices in detection of subacute combined exposure with methyl parathion and propoxur in rats

Cited by 12 publications

References 33 publications

Functional neurotoxic effects in rats acutely exposed to insecticide combinations

Functional neurotoxic effects in rats acutely exposed to insecticide combinations

Toxic effects of methamidophos on paraoxonase 1 activity and on rat kidney and liver and ameliorating effects of alpha‐tocopherol

Fallopian damage induced by organophosphate insecticide methyl parathion, and protective effect of vitamins E and C on ultrastructural changes in rats

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