Comparative Investigation of Various Adding Methods on Synthesis of Calcium Phosphate Containing Chinese Medicine

Abstract

The purpose of this paper was to investigate the effect of various Chinese medicine adding methods on their contents in calcium phosphate (CaP) and the crystal structure of the CaP comparatively. In the present study, CaP was synthesized by the wet chemistry method, in which starting reagent grades calcium nitrate and diammonium phosphate were used as the molar ratio Ca/P=1.5. Chinese medicine parenteral solution, Salvia Miltirrhiza Bunge (SMB), was added into the Ca2+ and PO43- reactive solutions before, during or after synthesis process. CaP was synthesized without adding SMB as the control. UV-VIS spectrophotometer was used to measure the supernatant absorbency. Zeta potential was used to characterize the various CaP slurries. Thermogravimetry, X-ray diffraction and transmission electron microscope were used to characterize the various powders, respectively. The presented results showed that adding SMB during the reaction can obtain the maximal medicine content among the four different adding methods. There was a slight effect on the crystal structure of CaP by adding SMB.

The effect of the major components of Salvia Miltiorrhiza Bunge on bone marrow cells

“…In our previous study, a commercial parenteral SMB preparation has been loaded onto various calcium phosphate bioceramics, including hydroxyapatite (Qu et al, 2005a;Huang et al, 2006) and calcium phosphate cement (Qu et al, 2005b;Y.R. Liu et al, 2006), which can be used for orthopaedic applications.…”

Development of Injectable Calcium Phosphate Cement Adding with ZrO₂

“…The analytical grade CA and ZrO 2 used in this study were purchased from Chengdu Chemical Reagents Company, China. HA and α-TCP were synthesized in our lab as previous [7]. The α-TCP was obtained by sintered Deficient Calcium Hydroxyapatite (DCHA) at 1100 o C for 6 h and quenched in air.…”

“…The α-TCP was obtained by sintered Deficient Calcium Hydroxyapatite (DCHA) at 1100 o C for 6 h and quenched in air. DCHA was synthesized by the wet chemical method from the analytical grade (NH 4 ) 2 HPO 4 and Ca(NO 3 ) 2 with the Ca/P ratio of 1.5 [7]. Then, HA and α-TCP were grounded by ball milling to get the fine powder with an average size of 8 µm measured by the Laser Particle Instrument, respecitvely.…”

Study on Synthesis of Calcium Phosphate Biomaterials Containing SMB

“…In our previous study, SMB parenteral solution was added into hydroxyapatite by a spray dryer [3]. Subsequently, SBM parenteral solution was added into the wet synthesis of CaP solution to obtain CaP biomaterials containing SMB [4]. However, CaP biomaterials were generally synthesized in the alkaline solution while the SMB was an acidic solution.…”